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AURKA aurora kinase A [ Homo sapiens (human) ]

Gene ID: 6790, updated on 12-May-2013

Summary

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Official Symbol: AURKAprovided by HGNC
Official Full Name: aurora kinase Aprovided by HGNC
Primary source: HGNC:11393
Locus tag: RP5-1167H4.6
See related: Ensembl:ENSG00000087586; HPRD:04066; HPRD:04352; MIM:603072; Vega:OTTHUMG00000032796
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47
Summary: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 20q13

Sequence :: Chromosome: 20; NC_000020.10 (54944445..54967351, complement)

See AURKA in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data thus revealed a novel role of AURKA as a negative regulator of autophagy, showing that AURKA inhibition induced autophagy.
Title: Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells.
Elevated protein expression of aurora A is associated with acute leukemia.
Title: Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target.
pancreatic ductal adenocarcinoma cells become resistant to the metabolic stress by activating an efficient intracellular defense pathway involving a Nupr1-dependent AURKA activation pathway.
Title: Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.
AURKA messenger RNA was expressed at significantly higher levels in mesenchymal stem cellss even with normal/altered karyotype when compared with hematopoietic cells and healthy donors
Title: Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH.
CYC3 was shown to be a specific AK-A inhibitor.
Title: Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
AURKA was identified as a marker for poor-risk gastrointestinal stromal tumors.
Title: Integrating bioinformatics and clinicopathological research of gastrointestinal stromal tumors: identification of aurora kinase A as a poor risk marker.
our results link CSCs, EMT, and CIN through the BMI1-AURKA axis
Title: Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer.
This is a review of the mitotic and non-mitotic functions of Aurora A, Aurora A regulation in the context of protein structural information, and the progress in understanding and inhibiting Aurora A in cancer. [review]
Title: Aurora A kinase (AURKA) in normal and pathological cell division.
The inhibition of the interaction between p53 and MDM2 by a novel Aurora-A-mediated p53 phosphorylation was identified
Title: A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2.
Expression of aurora kinase A/B was significantly up-regulated in chondrosarcoma, and was correlated with the recurrence and metastasis of chondrosarcoma and patient survival.
Title: Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis.

Submit: New GeneRIF Correction See all (280)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_003591.2	Q96EP1	CHFR	BIND	PubMed	STK6 (Aurora A) interacts with CHFR.
NP_003591.2	NP_002881.1	RASA1	BIND	PubMed	RasGAP interacts with HsAIRK-1.
NP_003591.2	NP_000537.2	TP53	BIND	PubMed	p53 interacts with STK15.
O14965	O14965	AURKA	HPRD	PubMed
O14965	Q9NWT8	AURKAIP1	HPRD	PubMed
O14965	Q6PGQ7	BORA	HPRD	PubMed
O14965	P38398	BRCA1	HPRD	PubMed
O14965	Q12834	CDC20	HPRD	PubMed
O14965	P30305	CDC25B	HPRD	PubMed
O14965	Checkpoint protein with FHA and ring finger domains	CHFR	HPRD	PubMed
O14965	Q14008	CKAP5	HPRD	PubMed
O14965	P49841	GSK3B	HPRD	PubMed
O14965	O95983	MBD3	HPRD	PubMed
O14965	O14777	NDC80	HPRD	PubMed
O14965	Q8N4C6	NIN	HPRD	PubMed
O14965	P15531	NME1	HPRD	PubMed
O14965	Q9BZD4	NUF2	HPRD	PubMed
O14965	P29590	PML	HPRD	PubMed
O14965	P62136	PPP1CA	HPRD	PubMed
O14965	P36873	PPP1CC	HPRD	PubMed
O14965	P17612	PRKACA	HPRD	PubMed
O14965	O75410	TACC1	HPRD	PubMed
O14965	Q9Y6A5	TACC3	HPRD	PubMed
O14965	P04637	TP53	HPRD	PubMed
O14965	Q9ULW0	TPX2	HPRD	PubMed
O14965	P61088	UBE2N	HPRD	PubMed
BioGRID:112666	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:112666	BioGRID:115402	ARPC1B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-fractionation; Reconstituted Complex
BioGRID:112666	BioGRID:115415	ARPC2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112666	BioGRID:112666	AURKA	BioGRID	PubMed	Affinity Capture-MS; Biochemical Activity
BioGRID:112666	BioGRID:120331	AURKAIP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:116641	AZI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:107056	BARD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:107140	BRCA1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:107263	CALU	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:107427	CDC20	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:107463	CDKN2A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:120432	CEP192	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:120861	CHFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:107834	CSN2	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:107971	DAB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:115131	DLGAP5	BioGRID	PubMed	Co-fractionation
BioGRID:112666	BioGRID:120581	FBXW7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:109315	HDAC1	BioGRID	PubMed	Negative Genetic
BioGRID:112666	BioGRID:109316	HDAC2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112666	BioGRID:115330	HDAC6	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:120968	HDAC8	BioGRID	PubMed	Negative Genetic
BioGRID:112666	BioGRID:113895	HIST3H3	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:109404	HMMR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112666	BioGRID:109831	INCENP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112666	BioGRID:200760	Incenp	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:112666	BioGRID:116195	KIF2C	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:117727	LATS2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-localization
BioGRID:112666	BioGRID:116581	MAPRE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:116178	MAPRE2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:116584	MAPRE3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:119788	MBD3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112666	BioGRID:110698	MYCN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:115675	NDC80	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:110859	NFKBIA	BioGRID	PubMed	Reconstituted Complex
BioGRID:112666	BioGRID:119372	NIN	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:110894	NME1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Two-hybrid
BioGRID:112666	BioGRID:123673	NUF2	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:229954	Nek9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:111362	PLK1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:112666	BioGRID:107663	PLK3	BioGRID	PubMed	Reconstituted Complex
	AAB19601.2	PML	BIND	PubMed	PML3 interacts with Aurora A.
BioGRID:112666	BioGRID:111384	PML	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:111493	PPP1CA	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:111494	PPP1CB	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:111495	PPP1CC	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:124224	PSRC1	BioGRID	PubMed	Co-fractionation
BioGRID:112666	BioGRID:117430	PTPN23	BioGRID	PubMed	Co-fractionation
BioGRID:112666	BioGRID:114663	PTTG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112666	BioGRID:116949	PUM2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112666	BioGRID:116096	RAB10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:114070	RANBP3	BioGRID	PubMed	Co-fractionation
BioGRID:112666	BioGRID:116356	RASSF1	BioGRID	PubMed	Biochemical Activity
BioGRID:112666	BioGRID:116982	SIRT3	BioGRID	PubMed	Positive Genetic
BioGRID:112666	BioGRID:112531	SOD2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:115788	SSSCA1	BioGRID	PubMed	Co-fractionation
BioGRID:112666	BioGRID:113188	SUMO1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112666	BioGRID:211070	Sirt2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:112666	BioGRID:112730	TACC1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:112666	BioGRID:115723	TACC3	BioGRID	PubMed	Biochemical Activity; Two-hybrid
BioGRID:112666	BioGRID:112760	TARS	BioGRID	PubMed	Co-fractionation
BioGRID:112666	BioGRID:112878	TFAP2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:115206	TLK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112666	BioGRID:116201	TLK2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112666	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:112666	BioGRID:113014	TP73	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112666	BioGRID:116624	TPX2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112666	BioGRID:113134	TUBG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112666	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:112666	BioGRID:113180	UBE2L3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112666	BioGRID:113182	UBE2N	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:114553	USP2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112666	BioGRID:99509	tpx2-a	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora A signaling, organism-specific biosystem
Aurora A signaling
Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora B signaling, organism-specific biosystem
Aurora B signaling
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
Gastric cancer network 1, organism-specific biosystem (from WikiPathways)
Gastric cancer network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
Oocyte meiosis, organism-specific biosystem (from KEGG)
Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Oocyte meiosis, conserved biosystem (from KEGG)
Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
PLK1 signaling events, organism-specific biosystem
PLK1 signaling events
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystem
Regulation of mitotic cell cycle
Signaling by Aurora kinases, organism-specific biosystem (from Pathway Interaction Database)
Signaling by Aurora kinases, organism-specific biosystem
Signaling by Aurora kinases

General gene information

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Markers

RH12027 (e-PCR)
- UniSTS:13896

RH80570 (e-PCR)
- UniSTS:84832

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-53807 (e-PCR)
- UniSTS:64439

Genotypes

See AURKA SNP Geneview Report
See AURKA SNP Genotype Report
See AURKA SNP Variation Viewer Report

Homology

Homologs of the AURKA gene: The AURKA gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info
cell cycle	NAS Non-traceable Author Statement more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
cell projection organization	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	TAS Traceable Author Statement more info
phosphatidylinositol-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
positive regulation of mitosis	TAS Traceable Author Statement more info	PubMed
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of centrosome cycle	TAS Traceable Author Statement more info	PubMed
regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
spindle organization	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
centrosome	IDA Inferred from Direct Assay more info
centrosome	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
midbody	TAS Traceable Author Statement more info	PubMed
nucleus	IDA Inferred from Direct Assay more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info
spindle	TAS Traceable Author Statement more info	PubMed
spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aurora kinase A

Names: aurora kinase A; ARK-1; hARK1; aurora 2; Aurora-A kinase; IPL1-related kinase; aurora-related kinase 1; aurora/IPL1-like kinase; serine/threonine kinase 6; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; serine/threonine-protein kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase aurora-A; protein phosphatase 1, regulatory subunit 47

NP_003591.2

EC 2.7.11.1

NP_940835.1

EC 2.7.11.1

NP_940836.1

EC 2.7.11.1

NP_940837.1

EC 2.7.11.1

NP_940838.1

EC 2.7.11.1

NP_940839.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012133.1 RefSeqGene

Range

5001..27907

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003600.2 → NP_003591.2 aurora kinase A

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AF008551, AF011468, AL711075, BU171303, CB138172

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

O14965

Related

ENSP00000216911, OTTHUMP00000031340, ENST00000347343, OTTHUMT00000079804

Conserved Domains (2) summary

cd05123
Location:139 – 382
Blast Score: 684

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:133 – 383
Blast Score: 800

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_198433.1 → NP_940835.1 aurora kinase A

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.

Source sequence(s)

AF008551, AF011468, AL711075, BC027464, BU171303, BU542363, CB138172

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

O14965

Related

ENSP00000379245, ENST00000395909

Conserved Domains (2) summary

cd05123
Location:139 – 382
Blast Score: 684

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:133 – 383
Blast Score: 800

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_198434.1 → NP_940836.1 aurora kinase A

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AF008551, AF011468, BM458030, BU171303, CB138172

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

O14965

Related

ENSP00000379250, ENST00000395914

Conserved Domains (2) summary

cd05123
Location:139 – 382
Blast Score: 684

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:133 – 383
Blast Score: 800

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_198435.1 → NP_940837.1 aurora kinase A

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AF011468, BU171303, CB138172

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

O14965

Related

ENSP00000379249, OTTHUMP00000031345, ENST00000395913, OTTHUMT00000079809

Conserved Domains (2) summary

cd05123
Location:139 – 382
Blast Score: 684

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:133 – 383
Blast Score: 800

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_198436.1 → NP_940838.1 aurora kinase A

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AF011468, BQ435059, CB113289, CB138172

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

O14965

Related

ENSP00000321591, OTTHUMP00000031343, ENST00000312783, OTTHUMT00000079807

Conserved Domains (2) summary

cd05123
Location:139 – 382
Blast Score: 684

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:133 – 383
Blast Score: 800

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_198437.1 → NP_940839.1 aurora kinase A

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AF008551, AF011468, BF029182, BU171303, CB138172

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

O14965

Related

ENSP00000379251, OTTHUMP00000031342, ENST00000395915, OTTHUMT00000079806

Conserved Domains (2) summary

cd05123
Location:139 – 382
Blast Score: 684

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:133 – 383
Blast Score: 800

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p10 Primary Assembly

Range

54944445..54967351, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

51729262..51752229, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018931.1 Alternate CHM1_1.0

Range

54914082..54936988, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01052891.1 (10386..33353)	None
genomic	AF011467.1	AAC23448.1
genomic	AF195947.1	AAF29508.1
genomic	AL121914.31 (41395..64301)	None
genomic	AMYH01012005.1 (85039..107945)	None
genomic	CH471077.2	EAW75550.1
		EAW75551.1
		EAW75552.1
		EAW75553.1
		EAW75554.1
		EAW75555.1
		EAW75556.1
		EAW75557.1
		EAW75558.1
		EAW75559.1
		EAW75560.1
		EAW75561.1
		EAW75562.1
mRNA	AF008551.1	AAC12708.1
mRNA	AF011468.1	AAC63902.1
mRNA	AK301769.1	BAG63228.1
mRNA	AK312776.1	BAG35640.1
mRNA	AL711075.1	None
mRNA	BC001280.1	AAH01280.1
mRNA	BC002499.2	AAH02499.1
mRNA	BC006423.1	AAH06423.1
mRNA	BC027464.1	AAH27464.1
mRNA	BF029182.1	None
mRNA	BM458030.1	None
mRNA	BQ435059.1	None
mRNA	BU171303.1	None
mRNA	BU542363.1	None
mRNA	CB113289.1	None
mRNA	CB138172.1	None
mRNA	D84212.1	BAA23592.1
other-genetic	AM392948.1	CAL37826.1
other-genetic	DQ891270.2	ABM82196.1
other-genetic	DQ894458.2	ABM85384.1