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AURKA aurora kinase A [ Homo sapiens (human) ]

Gene ID: 6790, updated on 29-Sep-2014
Official Symbol
AURKAprovided by HGNC
Official Full Name
aurora kinase Aprovided by HGNC
Primary source
HGNC:HGNC:11393
Locus tag
RP5-1167H4.6
See related
Ensembl:ENSG00000087586; HPRD:04066; HPRD:04352; MIM:603072; Vega:OTTHUMG00000032796
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47
Summary
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
See AURKA in Epigenomics, MapViewer
Location:
20q13
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (56369389..56392454, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (54944445..54967351, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene melanocortin 3 receptor Neighboring gene family with sequence similarity 210, member B Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa Neighboring gene Cas scaffolding protein family member 4 Neighboring gene ribosomal protein L39 pseudogene Neighboring gene replication termination factor 2 domain containing 1 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein aurora kinase A (AURKA, AURA) PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC34538

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 
protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic centrosome separation IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 
negative regulation of spindle checkpoint IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitosis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
 
regulation of centrosome cycle TAS
Traceable Author Statement
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle assembly involved in female meiosis I IEA
Inferred from Electronic Annotation
more info
 
spindle stabilization IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
axon hillock IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
germinal vesicle IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
midbody TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 
pronucleus IEA
Inferred from Electronic Annotation
more info
 
spindle TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole centrosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
aurora kinase A
Names
aurora kinase A
ARK-1
hARK1
aurora 2
Aurora-A kinase
IPL1-related kinase
aurora-related kinase 1
aurora/IPL1-like kinase
serine/threonine kinase 6
aurora/IPL1-related kinase 1
breast tumor-amplified kinase
breast-tumor-amplified kinase
serine/threonine-protein kinase 6
serine/threonine protein kinase 15
serine/threonine-protein kinase 15
serine/threonine-protein kinase aurora-A
protein phosphatase 1, regulatory subunit 47
NP_003591.2
NP_940835.1
NP_940836.1
NP_940837.1
NP_940838.1
NP_940839.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012133.1 

    Range
    5001..27907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003600.2NP_003591.2  aurora kinase A

    See proteins identical to NP_003591.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, AL711075, BU171303, CB138172
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000216911, OTTHUMP00000031340, ENST00000347343, OTTHUMT00000079804
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_198433.1NP_940835.1  aurora kinase A

    See proteins identical to NP_940835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, AL711075, BC027464, BU171303, BU542363, CB138172
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. NM_198434.1NP_940836.1  aurora kinase A

    See proteins identical to NP_940836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, BM458030, BU171303, CB138172
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000379250, ENST00000395914
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. NM_198435.1NP_940837.1  aurora kinase A

    See proteins identical to NP_940837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF011468, BU171303, CB138172
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000379249, OTTHUMP00000031345, ENST00000395913, OTTHUMT00000079809
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. NM_198436.1NP_940838.1  aurora kinase A

    See proteins identical to NP_940838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF011468, BQ435059, CB113289, CB138172
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000321591, OTTHUMP00000031343, ENST00000312783, OTTHUMT00000079807
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  6. NM_198437.1NP_940839.1  aurora kinase A

    See proteins identical to NP_940839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.
    Source sequence(s)
    AF008551, AF011468, BF029182, BU171303, CB138172
    Consensus CDS
    CCDS13451.1
    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000379251, OTTHUMP00000031342, ENST00000395915, OTTHUMT00000079806
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    56369389..56392454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723871.1XP_006723934.1  

    Conserved Domains (2) summary
    cd05123
    Location:155398
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:149399
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_005260534.1XP_005260591.1  

    See proteins identical to XP_005260591.1

    UniProtKB/Swiss-Prot
    O14965
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. XM_006723872.1XP_006723935.1  

    See proteins identical to XP_006723935.1

    UniProtKB/Swiss-Prot
    O14965
    Related
    ENSP00000360407, OTTHUMP00000031344, ENST00000371356, OTTHUMT00000079808
    Conserved Domains (2) summary
    cd05123
    Location:139382
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:133383
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    51729262..51752229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    54845539..54868444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)