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    Ccdc80 coiled-coil domain containing 80 [ Mus musculus (house mouse) ]

    Gene ID: 67896, updated on 26-Feb-2013
    Official Symbol
    Ccdc80provided by MGI
    Official Full Name
    coiled-coil domain containing 80provided by MGI
    Primary source
    MGI:1915146
    See related
    Ensembl:ENSMUSG00000022665; Vega:OTTMUSG00000025346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Urb; DRO1; Ssg1; 2610001E17Rik
    Location :
    16; 16 B5
    Sequence :
    Chromosome: 16; NC_000082.6 (45094053..45127924)
    See Ccdc80 in Epigenomics, MapViewer

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene Cd200 receptor 2 Neighboring gene Cd200 receptor 2 pseudogene Neighboring gene CD200 receptor 3 Neighboring gene predicted gene 10808 Neighboring gene solute carrier family 35, member A5

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice. Tremblay F, et al. Endocrinology, 2012 Sep. PMID 22753645.
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    4. Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. Nordstrand LM, et al. PLoS One, 2010 Nov 3. PMID 21072209.
    5. Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB. Tremblay F, et al. J Biol Chem, 2009 Mar 20. PMID 19141617.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results suggest that Ccdc80 is a novel modulator of glucose and energy homeostasis during diet-induced obesity.
      Title: Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
    2. Ccdc80 plays dual roles in adipogenesis by mechanisms that involve at least in part down-regulation of Wnt/beta-catenin signaling and induction of C/EBPalpha and peroxisome proliferator-activated receptor gamma.
      Title: Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.
    3. In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes.
      Title: URB is abundantly expressed in adipose tissue and dysregulated in obesity.
    4. Downregulated during osteoblastic differentiation of bone marrow stromal cells. Suggests role in skeletogenesis.
      Title: URB expression in human bone marrow stromal cells and during mouse development.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fibronectin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    interstitial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    coiled-coil domain-containing protein 80
    Names
    coiled-coil domain-containing protein 80
    steroid sensitive gene 1
    up-regulated in BRS-3 deficient mouse

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026439.2 → NP_080715.2  coiled-coil domain-containing protein 80 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AK132178
      Consensus CDS
      CCDS28192.1
      UniProtKB/Swiss-Prot
      Q8R2G6
      Related
      ENSMUSP00000058752, ENSMUST00000061050
      Conserved Domains (1) summary
      pfam13778
      Location:140 – 270
      Blast Score: 279
      DUF4174; Domain of unknown function (DUF4174)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p1 C57BL/6J

      Range
      45094053..45127924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      45485370..45521051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01127489.1 (1411..16585) None
    genomic AAHY01127490.1 None
    genomic AAHY01127491.1 None
    genomic AAHY01127492.1 None
    genomic AAHY01127493.1 None
    genomic AAHY01127494.1 None
    genomic AC124600.5 None
    genomic AC129601.4 (66562..78169) None
    genomic CH466521.1 EDK98058.1 mixed
    mRNA AB075019.1 BAB85613.1 C57BL/6J
    mRNA AK009795.1 BAB26508.1 C57BL/6J
    mRNA AK011256.1 BAB27498.1 C57BL/6J
    mRNA AK020169.1 BAB32018.1 C57BL/6J
    mRNA AK032359.1 BAC27834.1 C57BL/6J
    mRNA AK047367.1 None C57BL/6J
    mRNA AK132178.1 BAE21015.1 C57BL/6J
    mRNA AK144183.1 None
    mRNA BC022704.1 AAH22704.1 FVB/N
    mRNA BC058751.1 AAH58751.1 FVB/N-3
    mRNA BC096487.1 AAH96487.1 NMRI
    other-genetic BC167202.1 AAI67202.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2G6.2 GenPept UniProtKB/Swiss-Prot:Q8R2G6

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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