STK4 serine/threonine kinase 4 [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: STK4provided by HGNC
Official Full Name: serine/threonine kinase 4provided by HGNC
Primary source: HGNC:11408
See related: Ensembl:ENSG00000101109; HPRD:05395; MIM:604965; Vega:OTTHUMG00000033059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KRS2; MST1; YSK3; TIIAC
Summary: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 20q11.2-q13.2

Sequence :: Chromosome: 20; NC_000020.10 (43595120..43708594)

See STK4 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low expression of MST1 may be related with the pathogenesis and prognosis of acute leukemia.
Title: [Expression of Hippo signaling pathway core element MST1 in acute leukemia patients and its significance].
Data suggest that phosphoinositide-3-kinase/Akt and mammalian target of rapamycin (mTOR) pathway signaling differentially regulate phospho-Mst1-Thr-120/Thr-183.
Title: Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.
MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival.
Title: MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival.
STK4 deficiency is a novel human primary immunodeficiency syndrome.
Title: The phenotype of human STK4 deficiency.
Data indicate that dimerization domain of MST1 is unstructured as monomer and undergoes dimerization-induced folding. Data indicate that inhibitory domain of MST1 is disordered region both as single domain and as construct with dimerization domain.
Title: Dimerization-induced folding of MST1 SARAH and the influence of the intrinsically unstructured inhibitory domain: low thermodynamic stability of monomer.
results show a novel PRX-I function to cause cell death in response to high levels of oxidative stress by activating MST1, which underlies the p53-dependent cytotoxicity caused by anticancer agents
Title: Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis.
Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.
Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
MST1 was also found in androgen receptor (AR)-chromatin complexes, and enforced expression of MST1 reduced the binding of AR to a well-characterized, androgen-responsive region within the prostate-specific antigen promo
Title: MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.
Phage microarrays containing colorectal cancer cDNA libraries were prepared to identify phage-expressed peptides recognized by tumor-specific autoantibodies from patient sera.
Title: Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays.
Through binding to MST1/2, RASSF1A supports maintenance of MST1/2 phosphorylation, promoting an active state of the MST kinases and favoring induction of apoptosis.
Title: The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.

Submit: New GeneRIF Correction See all (23)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

T-cell immunodeficiency, recurrent infections, and autoimmunity with or without cardiac malformations

MIM: 614868

Genetic Testing Registry

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
NP_006273.1	NP_004681.1	LATS1	BIND	PubMed	STK4 (Mst1) phosphorylates Lats1.
NP_006273.1	NP_006273.1	STK4	BIND	PubMed	STK4 (Mst1) autophosphorylates.
Q13043	P42574	CASP3	HPRD	PubMed
Q13043	Q969H4	CNKSR1	HPRD	PubMed
Q13043	P47710	CSN1S1	HPRD	PubMed
Q13043	O95835	LATS1	HPRD	PubMed
Q13043	P02686	MBP	HPRD	PubMed
Q13043	O43422	PRKRIR	HPRD	PubMed
Q13043	Q9NS23	RASSF1	HPRD	PubMed
Q13043	Q8WWW0	RASSF5	HPRD	PubMed
Q13043	Q9H4B6	SAV1	HPRD	PubMed
Q13043	Q13043	STK4	HPRD	PubMed
Q13043	P04637	TP53	HPRD	PubMed
BioGRID:112665	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112665	BioGRID:106710	AKT1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112665	BioGRID:115550	CNKSR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112665	BioGRID:113743	CUL5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:112665	BioGRID:108598	FOXO3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112665	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112665	BioGRID:113945	HIST2H2BE	BioGRID	PubMed	Biochemical Activity
BioGRID:112665	BioGRID:109776	IL2RG	BioGRID	PubMed	Two-hybrid
BioGRID:112665	BioGRID:110304	MAP1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:124137	MAP1LC3A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:123565	MAP1LC3B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:110811	NEDD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:112665	BioGRID:111598	PRKRIR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112665	BioGRID:116356	RASSF1	BioGRID	PubMed	Affinity Capture-MS; Two-hybrid
BioGRID:112665	BioGRID:115115	RASSF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:123820	RASSF4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:123689	RASSF5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:207877	Rassf1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:112192	S100A13	BioGRID	PubMed	Co-fractionation
BioGRID:112665	BioGRID:121917	SAV1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:129227	SGMS1	BioGRID	PubMed	Biochemical Activity
BioGRID:112665	BioGRID:116983	SIRT1	BioGRID	PubMed	Biochemical Activity
BioGRID:112665	BioGRID:126147	SLX4IP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:112664	STK3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:112665	STK4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:112665	BioGRID:121607	TAOK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112665	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

Go to the top of the page Help

MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Non-small cell lung cancer, organism-specific biosystem (from KEGG)
Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Non-small cell lung cancer, conserved biosystem (from KEGG)
Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by Hippo, organism-specific biosystem (from REACTOME)
Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...

General gene information

Go to the top of the page Help

Markers

Z94383 (e-PCR)
- UniSTS:80135

D20S119 (e-PCR), detects polymorphism
- UniSTS:37902

D20S119 (e-PCR), detects polymorphism
- UniSTS:3353

RH18007 (e-PCR)
- UniSTS:34846

D20S1069 (e-PCR)
- UniSTS:29490

D8S2279 (e-PCR)
- UniSTS:473907

RH66078 (e-PCR)
- UniSTS:9534

NoName (e-PCR)
- UniSTS:483393

GDB:314949 (e-PCR)
- UniSTS:156503

L18426 (e-PCR)
- UniSTS:34648

D17S1239 (e-PCR)
- UniSTS:149852

G38154 (e-PCR)
- UniSTS:53341

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

RH47839 (e-PCR)
- UniSTS:15494

AL022266 (e-PCR)
- UniSTS:75419

RH68914 (e-PCR)
- UniSTS:31144

AL023484 (e-PCR)
- UniSTS:50097

Z94386 (e-PCR)
- UniSTS:8125

SHGC-106156 (e-PCR)
- UniSTS:169664

Genotypes

See STK4 SNP Geneview Report
See STK4 SNP Genotype Report
See STK4 SNP Variation Viewer Report

Homology

Homologs of the STK4 gene: The STK4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info
protein serine/threonine kinase activity	EXP Inferred from Experiment more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
cell differentiation involved in embryonic placenta development	IEA Inferred from Electronic Annotation more info
cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
central nervous system development	IEA Inferred from Electronic Annotation more info
endocardium development	IEA Inferred from Electronic Annotation more info
hippo signaling cascade	IDA Inferred from Direct Assay more info
hippo signaling cascade	TAS Traceable Author Statement more info	PubMed
induction of apoptosis	IDA Inferred from Direct Assay more info
intracellular protein kinase cascade	IDA Inferred from Direct Assay more info	PubMed
keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of organ growth	IEA Inferred from Electronic Annotation more info
neural tube formation	IEA Inferred from Electronic Annotation more info
patterning of blood vessels	IEA Inferred from Electronic Annotation more info
peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info
primitive hemopoiesis	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info

General protein information

Go to the top of the page Help

Preferred Names: serine/threonine-protein kinase 4

Names: serine/threonine-protein kinase 4; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))

NP_006273.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032172.1 RefSeqGene

Range

5001..118475

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_535

mRNA and Protein(s)

NM_006282.2 → NP_006273.1 serine/threonine-protein kinase 4

Status: REVIEWED

Source sequence(s)

AK027088, AL597960, BC038850, BC042861, BM450795, BM455776, BM459914, BQ216721, BQ434275, BU153393, BU429479, BU633556, BU689980, BU902081, T18610, U60207

Consensus CDS

CCDS13341.1

UniProtKB/Swiss-Prot

Q13043

Related

ENSP00000361892, OTTHUMP00000043418, ENST00000372806, OTTHUMT00000080401

Conserved Domains (3) summary

cd06612
Location:26 – 281
Blast Score: 1400

STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2

pfam11629
Location:432 – 480
Blast Score: 230

Mst1_SARAH; C terminal SARAH domain of Mst1

smart00220
Location:30 – 281
Blast Score: 845

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p10 Primary Assembly

Range

43595120..43708594

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

40336825..40450492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018931.1 Alternate CHM1_1.0

Range

43565713..43679282

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01052655.1 (67399..72074)	None
genomic	ABBA01052656.1	None
genomic	ABBA01052657.1	None
genomic	AL109839.11	None
genomic	AMYH01011936.1 (35428..80682)	None
genomic	AMYH01011937.1	None
genomic	CH471077.2	EAW75882.1
		EAW75883.1
genomic	Z93016.2 (34299..80737)	None
mRNA	AB209315.1	BAD92552.1
mRNA	AK027088.1	None
mRNA	AK225326.1	None
mRNA	AK309169.1	None
mRNA	AK315238.1	BAG37665.1
mRNA	AL597960.1	None
mRNA	BC005231.1	AAH05231.1
mRNA	BC015332.1	AAH15332.1
mRNA	BC029511.1	AAH29511.1
mRNA	BC038850.1	None
mRNA	BC039023.1	None
mRNA	BC042861.1	None
mRNA	BC058916.1	AAH58916.1
mRNA	BC065215.1	None
mRNA	BC093768.1	AAH93768.1
mRNA	BM450795.1	None
mRNA	BM455776.1	None
mRNA	BM459914.1	None
mRNA	BQ216721.1	None
mRNA	BQ434275.1	None
mRNA	BU153393.1	None
mRNA	BU429479.1	None
mRNA	BU633556.1	None
mRNA	BU689980.1	None
mRNA	BU902081.1	None
mRNA	CR933633.1	CAI45939.1
mRNA	T18610.1	None
mRNA	U18297.1	AAA83254.1
mRNA	U60207.1	AAB17262.1
mRNA	Z25430.1	CAA80917.1