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STK4 serine/threonine kinase 4 [ Homo sapiens (human) ]

Gene ID: 6789, updated on 12-Apr-2014
Official Symbol
STK4provided by HGNC
Official Full Name
serine/threonine kinase 4provided by HGNC
Primary source
HGNC:11408
See related
Ensembl:ENSG00000101109; HPRD:05395; MIM:604965; Vega:OTTHUMG00000033059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRS2; MST1; YSK3; TIIAC
Summary
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Location :
20q11.2-q13.2
Sequence :
Chromosome: 20; NC_000020.11 (44966479..45079959)
See STK4 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene STK4 antisense RNA 1 (head to head) Neighboring gene potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 Neighboring gene WAP four-disulfide core domain 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
    Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Non-small cell lung cancer, conserved biosystem (from KEGG)
    Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
 
cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
endocardium development IEA
Inferred from Electronic Annotation
more info
 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
hippo signaling IDA
Inferred from Direct Assay
more info
 
hippo signaling TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
neural tube formation IEA
Inferred from Electronic Annotation
more info
 
patterning of blood vessels IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
primitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase 4
Names
serine/threonine-protein kinase 4
MST-1
STE20-like kinase MST1
mammalian sterile 20-like 1
kinase responsive to stress 2
mammalian STE20-like protein kinase 1
serine/threonine-protein kinase Krs-2
dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
NP_006273.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032172.1 RefSeqGene

    Range
    5001..118475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_535

mRNA and Protein(s)

  1. NM_006282.2NP_006273.1  serine/threonine-protein kinase 4

    See proteins identical to NP_006273.1

    Status: REVIEWED

    Source sequence(s)
    AK027088, AL597960, BC038850, BC042861, BM450795, BM455776, BM459914, BQ216721, BQ434275, BU153393, BU429479, BU633556, BU689980, BU902081, T18610, U60207
    Consensus CDS
    CCDS13341.1
    UniProtKB/Swiss-Prot
    Q13043
    Related
    ENSP00000361892, OTTHUMP00000043418, ENST00000372806, OTTHUMT00000080401
    Conserved Domains (3) summary
    cd06612
    Location:26281
    Blast Score: 1417
    STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
    pfam11629
    Location:432480
    Blast Score: 241
    Mst1_SARAH; C terminal SARAH domain of Mst1
    smart00220
    Location:30281
    Blast Score: 856
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11

    Range
    44966479..45079959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260533.1XP_005260590.1  

    See proteins identical to XP_005260590.1

    UniProtKB/Swiss-Prot
    Q13043
    Conserved Domains (2) summary
    cd06612
    Location:26281
    Blast Score: 1421
    STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
    smart00220
    Location:30281
    Blast Score: 860
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_005260530.1XP_005260587.1  

    Conserved Domains (3) summary
    cd06612
    Location:42297
    Blast Score: 1414
    STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
    pfam11629
    Location:448496
    Blast Score: 244
    Mst1_SARAH; C terminal SARAH domain of Mst1
    smart00220
    Location:46297
    Blast Score: 854
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. XM_005260531.1XP_005260588.1  

    Related
    ENSP00000379957, ENST00000396731
    Conserved Domains (2) summary
    cd06612
    Location:42297
    Blast Score: 1418
    STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
    smart00220
    Location:46297
    Blast Score: 858
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_005260532.1XP_005260589.1  

    See proteins identical to XP_005260589.1

    Conserved Domains (3) summary
    cd06612
    Location:17268
    Blast Score: 1345
    STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
    pfam11629
    Location:419467
    Blast Score: 245
    Mst1_SARAH; C terminal SARAH domain of Mst1
    smart00220
    Location:24268
    Blast Score: 818
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. XM_006723870.1XP_006723933.1  

    See proteins identical to XP_006723933.1

    Conserved Domains (3) summary
    cd06612
    Location:17268
    Blast Score: 1345
    STKc_MST1_2; Catalytic domain of the Protein Serine/Threonine Kinases, Mammalian Ste20-like protein kinase 1 and 2
    pfam11629
    Location:419467
    Blast Score: 245
    Mst1_SARAH; C terminal SARAH domain of Mst1
    smart00220
    Location:24268
    Blast Score: 818
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate HuRef

Genomic

  1. AC_000152.1 Alternate HuRef

    Range
    40336825..40450492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    43497900..43611341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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