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NEK4 NIMA related kinase 4 [ Homo sapiens (human) ]

Gene ID: 6787, updated on 26-May-2016
Official Symbol
NEK4provided by HGNC
Official Full Name
NIMA related kinase 4provided by HGNC
Primary source
HGNC:HGNC:11399
See related
Ensembl:ENSG00000114904 HPRD:11880; MIM:601959; Vega:OTTHUMG00000158836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRK2; STK2; pp12301
Orthologs
Location:
3p21.1
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (52710780..52770949, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52744796..52804965, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene G protein nucleolar 3 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene zinc finger protein 610 pseudogene Neighboring gene adenylate kinase 3 pseudogene Neighboring gene AKT-interacting protein-like Neighboring gene inter-alpha-trypsin inhibitor heavy chain 1 Neighboring gene uncharacterized LOC105377093 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction by protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
serine/threonine-protein kinase Nek4
Names
NIMA (never in mitosis gene a)-related kinase 4
NIMA-related kinase 4
never in mitosis A-related kinase 4
nimA-related protein kinase 4
serine/threonine kinase 2
serine/threonine protein kinase-2
serine/threonine-protein kinase 2
serine/threonine-protein kinase NRK2
serine/threonine-protein kinase Nek4 variant 2
NP_001180462.1
NP_003148.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193533.1NP_001180462.1  serine/threonine-protein kinase Nek4 isoform 2

    See identical proteins and their annotated locations for NP_001180462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, 5' coding region segment, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI860526, AK294165, DB073127, L20321
    Consensus CDS
    CCDS54593.1
    UniProtKB/Swiss-Prot
    P51957
    Related
    ENSP00000437703, ENST00000535191
    Conserved Domains (2) summary
    smart00220
    Location:31172
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:5172
    PKc_like; Protein Kinases, catalytic domain
  2. NM_003157.4NP_003148.2  serine/threonine-protein kinase Nek4 isoform 1

    See identical proteins and their annotated locations for NP_003148.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AI860526, BC015515, DB073127, L20321
    Consensus CDS
    CCDS2863.1
    UniProtKB/Swiss-Prot
    P51957
    UniProtKB/TrEMBL
    Q05DF6
    Related
    ENSP00000233027, OTTHUMP00000213580, ENST00000233027, OTTHUMT00000352386
    Conserved Domains (2) summary
    smart00220
    Location:6261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    52710780..52770949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713310.1XP_006713373.1  

    Related
    ENSP00000373227, OTTHUMP00000213581, ENST00000383721, OTTHUMT00000352387
    Conserved Domains (2) summary
    smart00220
    Location:6261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4
  2. XM_011534039.1XP_011532341.1  

    Conserved Domains (2) summary
    smart00220
    Location:6261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4
  3. XM_011534040.1XP_011532342.1  

    Conserved Domains (2) summary
    smart00220
    Location:6261
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08223
    Location:5261
    STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    52696967..52757147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)