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Hapln3 hyaluronan and proteoglycan link protein 3 [ Mus musculus (house mouse) ]

Gene ID: 67666, updated on 21-Apr-2024

Summary

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Official Symbol
Hapln3provided by MGI
Official Full Name
hyaluronan and proteoglycan link protein 3provided by MGI
Primary source
MGI:MGI:1914916
See related
Ensembl:ENSMUSG00000030606 AllianceGenome:MGI:1914916
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lpr3; 4930554N11Rik
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be involved in central nervous system development and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human HAPLN3 (hyaluronan and proteoglycan link protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 1.7), genital fat pad adult (RPKM 1.7) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 44.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78766775..78783100, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79117027..79133173, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31213 Neighboring gene predicted gene, 26633 Neighboring gene aggrecan Neighboring gene STARR-seq mESC enhancer starr_19258 Neighboring gene milk fat globule EGF and factor V/VIII domain containing Neighboring gene STARR-seq mESC enhancer starr_19263 Neighboring gene STARR-seq mESC enhancer starr_19264 Neighboring gene predicted gene, 39040

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency. Czipri M, et al. J Biol Chem, 2003 Oct 3. PMID 12732630
  2. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. Spicer AP, et al. J Biol Chem, 2003 Jun 6. PMID 12663660
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC124072

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perineuronal net IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hyaluronan and proteoglycan link protein 3
Names
link protein 3
NP_839986.2
XP_006541190.1
XP_006541191.1
XP_036009276.1
XP_036009277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178255.3 → NP_839986.2  hyaluronan and proteoglycan link protein 3 precursor

    See identical proteins and their annotated locations for NP_839986.2

    Status: PROVISIONAL

    Source sequence(s)
    AY262757
    Consensus CDS
    CCDS21378.1
    UniProtKB/Swiss-Prot
    Q3UVT2, Q80WM5, Q80XX3
    UniProtKB/TrEMBL
    Q2NLE4
    Related
    ENSMUSP00000146090.2, ENSMUST00000206092.2
    Conserved Domains (3) summary
    cd03518
    Location:166 → 260
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:267 → 356
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd05877
    Location:52 → 168
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    78766775..78783100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541128.5 → XP_006541191.1  hyaluronan and proteoglycan link protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006541191.1

    UniProtKB/Swiss-Prot
    Q3UVT2, Q80WM5, Q80XX3
    UniProtKB/TrEMBL
    Q2NLE4
    Conserved Domains (3) summary
    cd03518
    Location:166 → 260
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:267 → 356
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd05877
    Location:52 → 168
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains

  2. XM_006541127.5 → XP_006541190.1  hyaluronan and proteoglycan link protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006541190.1

    UniProtKB/Swiss-Prot
    Q3UVT2, Q80WM5, Q80XX3
    UniProtKB/TrEMBL
    Q2NLE4
    Conserved Domains (3) summary
    cd03518
    Location:166 → 260
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:267 → 356
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd05877
    Location:52 → 168
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains

  3. XM_036153384.1 → XP_036009277.1  hyaluronan and proteoglycan link protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q3UVT2, Q80WM5, Q80XX3
    UniProtKB/TrEMBL
    Q2NLE4
    Conserved Domains (3) summary
    cd03518
    Location:166 → 260
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:267 → 356
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd05877
    Location:52 → 168
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains

  4. XM_036153383.1 → XP_036009276.1  hyaluronan and proteoglycan link protein 3 isoform X1

    UniProtKB/TrEMBL
    Q2NLE4
    Conserved Domains (3) summary
    cd03518
    Location:189 → 283
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:290 → 379
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd05877
    Location:75 → 191
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80WM5.3 GenPept UniProtKB/Swiss-Prot:Q80WM5

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