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    BRDT bromodomain, testis-specific [ Homo sapiens ]

    Gene ID: 676, updated on 11-May-2012
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    Summary

    Official Symbol
    BRDTprovided by HGNC
    Official Full Name
    bromodomain, testis-specificprovided by HGNC
    Primary source
    HGNC:1105
    See related
    Ensembl:ENSG00000137948; HPRD:03684; MIM:602144; Vega:OTTHUMG00000010113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT9; BRD6
    Summary
    BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
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    Genomic context

    Location :
    1p22.1
    Sequence :
    Chromosome: 1; NC_000001.10 (92414928..92479985)
    See BRDT in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene heat shock protein 90kDa beta (Grp94), member 3, pseudogene Neighboring gene transforming growth factor, beta receptor III Neighboring gene epoxide hydrolase 4 Neighboring gene lysophosphatidylcholine acyltransferase 2b, pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Expression of BET genes in testis of men with different spermatogenic impairments. Barda S, et al. Fertil Steril, 2012 Jan. PMID 22035730.
    2. The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men. Steilmann C, et al. Reproduction, 2010 Sep. PMID 20538714.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Aston KI, et al. Hum Reprod, 2010 Jun. PMID 20378615.
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. In human, BRDT is the only BET gene expressed exclusively in testicular germ cells.
      Title: Expression of BET genes in testis of men with different spermatogenic impairments.
    2. Suggest that reduced histone methylation in the promoter of BRDT may be associated with increased transcript levels in subfertile patients.
      Title: The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
    5. BRDT-NY gene is an alternatively spliced variant that may have an important role in the process of spermatogenesis and may be correlated with male infertility
      Title: Molecular cloning and expression of a novel alternative splice variant of BRDT gene.
    6. BRDT is a testis-specific bromodomain-containing protein
      Title: Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q58F21 Histone 2 H4 HIST2H4A    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    bromodomain testis-specific protein
    Names
    bromodomain testis-specific protein
    RING3-like protein
    cancer/testis antigen 9
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242805.1 → NP_001229734.1  bromodomain testis-specific protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (b) lacks a short internal segment compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).
      Source sequence(s)
      AC114486, AK303008, AY338951, BX648135
      Consensus CDS
      CCDS735.1
      UniProtKB/TrEMBL
      B7Z890
      UniProtKB/Swiss-Prot
      Q58F21
      Related
      ENSP00000354568, OTTHUMP00000011809, ENST00000362005, OTTHUMT00000027980
      Conserved Domains (2) summary
      cd05497
      Location:27 – 133
      Blast Score: 565
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:272 – 373
      Blast Score: 505
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

    2. NM_001242806.1 → NP_001229735.1  bromodomain testis-specific protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (a).
      Source sequence(s)
      AC114486, AK302758, AK303008, AY338951, BX648135, DB072781
      UniProtKB/TrEMBL
      B7Z811
      UniProtKB/TrEMBL
      B7Z890
      UniProtKB/Swiss-Prot
      Q58F21
      Conserved Domains (2) summary
      cd05497
      Location:27 – 133
      Blast Score: 566
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:276 – 377
      Blast Score: 505
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

    3. NM_001242807.1 → NP_001229736.1  bromodomain testis-specific protein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (c) lacks two internal segments compared to isoform a. Variants 5 and 6 both encode the same protein.
      Source sequence(s)
      AK316442, AY338951, BX648135, DC402057
      Consensus CDS
      CCDS55615.1
      UniProtKB/TrEMBL
      B7ZAX7
      UniProtKB/Swiss-Prot
      Q58F21
      Related
      ENSP00000378038, ENST00000394530
      Conserved Domains (2) summary
      cd05498
      Location:226 – 327
      Blast Score: 508
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cl02556
      Location:27 – 87
      Blast Score: 256
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    4. NM_001242808.1 → NP_001229737.1  bromodomain testis-specific protein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (c) lacks two internal segments compared to isoform a. Variants 5 and 6 both encode the same protein.
      Source sequence(s)
      AC114486, AK302758, AK303008, AY338951, BX648135
      Consensus CDS
      CCDS55615.1
      UniProtKB/TrEMBL
      B7Z811
      UniProtKB/TrEMBL
      B7Z890
      UniProtKB/Swiss-Prot
      Q58F21
      Conserved Domains (2) summary
      cd05498
      Location:226 – 327
      Blast Score: 508
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cl02556
      Location:27 – 87
      Blast Score: 256
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    5. NM_001242810.1 → NP_001229739.1  bromodomain testis-specific protein isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (d) is shorter at the N-terminus and lacks a short internal segment compared to isoform a.
      Source sequence(s)
      AC114486, AK303008, AY338951, BX648135
      Consensus CDS
      CCDS55616.1
      UniProtKB/TrEMBL
      B7Z890
      UniProtKB/Swiss-Prot
      Q58F21
      Related
      ENSP00000359416, OTTHUMP00000011810, ENST00000370389, OTTHUMT00000027981
      Conserved Domains (2) summary
      cd05498
      Location:199 – 300
      Blast Score: 505
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cl02556
      Location:1 – 60
      Blast Score: 315
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    6. NM_001726.3 → NP_001717.2  bromodomain testis-specific protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (b) lacks a short internal segment compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).
      Source sequence(s)
      AY338951, BC047900, BX648135, DC401352
      Consensus CDS
      CCDS735.1
      UniProtKB/Swiss-Prot
      Q58F21
      Related
      ENSP00000384051, OTTHUMP00000197577, ENST00000402388, OTTHUMT00000318475
      Conserved Domains (2) summary
      cd05497
      Location:27 – 133
      Blast Score: 565
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:272 – 373
      Blast Score: 505
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

    7. NM_207189.2 → NP_997072.1  bromodomain testis-specific protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 4. The resulting isoform (b) lacks a short internal segment compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).
      Source sequence(s)
      AC114486, AY338951, BC017582, BC047900, BX648135
      Consensus CDS
      CCDS735.1
      UniProtKB/Swiss-Prot
      Q58F21
      Related
      ENSP00000387822, ENST00000399546
      Conserved Domains (2) summary
      cd05497
      Location:27 – 133
      Blast Score: 565
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:272 – 373
      Blast Score: 505
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      92414928..92479985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      90535222..90600191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC114486.2 (74295..139351) None
    genomic CH471097.2 EAW73106.1
      EAW73107.1
      EAW73108.1
      EAW73109.1
      EAW73110.1
      EAW73111.1
    mRNA AF019085.1 AAB87862.1
    mRNA AK302758.1 BAH13797.1
    mRNA AK303008.1 BAH13876.1
    mRNA AK316442.1 BAH14813.1
    mRNA AY338951.1 AAQ16198.1
    mRNA BC005281.1 AAH05281.1
    mRNA BC017582.1 AAH17582.1
    mRNA BC028126.2 None
    mRNA BC038844.2 None
    mRNA BC047900.1 AAH47900.1
    mRNA BC062700.1 AAH62700.1
    mRNA BG717291.1 None
    mRNA BX648135.1 None
    mRNA DB072781.1 None
    mRNA DC401352.1 None
    mRNA DC402057.1 None
    other-genetic BC111927.1 AAI11928.1
    other-genetic BC118498.1 AAI18499.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05DQ4 GenPept UniProtKB/TrEMBL:Q05DQ4
    Q58F21.4 GenPept UniProtKB/Swiss-Prot:Q58F21
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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