BRCA2 breast cancer 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRCA2provided by HGNC
Official Full Name: breast cancer 2provided by HGNC
Primary source: HGNC:HGNC:1101
See related: Ensembl:ENSG00000139618; HPRD:02554; MIM:600185; Vega:OTTHUMG00000017411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2
Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
Orthologs: mouse all

Genomic context

Location:: 13q12.3

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
107	current	GRCh38.p2 (GCF_000001405.28)	13	NC_000013.11 (32314862..32399850)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (32889617..32973809)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Taking into account modifier factors, location of mutation might be important for the clinical management of BRCA1/2 mutation carriers.
Title: Breast Cancer Risk Associated with Estrogen Exposure and Truncating Mutation Location in BRCA1/2 Carriers.
BRCA2 mutation carriers demonstrated normal ovarian response in IVF cycles.
Title: BRCA mutation carriers show normal ovarian response in in vitro fertilization cycles.
study identified a BRCA1 or BRCA2 germline mutation in 74 of 774 (9.6 %) triple-negative breast cancer patients; mutation prevalence was 9.3 % in Australia and was 9.9 % in Poland
Title: Prevalence of BRCA1 and BRCA2 germline mutations in patients with triple-negative breast cancer.
By binding and destabilizing a histone acetyltransferase, p300, beta-HPV 5 and 8 E6 reduce the enrichment of the transcription factor at the promoter of two genes critical to the homology dependent repair of DSBs (BRCA1 and BRCA2)
Title: β-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation.
BRCA2 gene mutation is associated with breast cancer.
Title: Feelings of Women With Strong Family Histories Who Subsequent to Their Breast Cancer Diagnosis Tested BRCA Positive.
BRCA1 gene mutation is associated with gynecologic cancer.
Title: Endometrial cancers in mutation carriers from hereditary breast ovarian cancer syndrome kindreds: report from the Creighton University Hereditary Cancer Registry with review of the implications.
this work gives the first evidence of a BRCA2 germline pathogenic mutation associated with CRC risk.
Title: BRCA2 gene: a candidate for clinical testing in familial colorectal cancer type X.
analysis of novel A1/2 mutations in Polish patients with familial breast/ovarian cancer
Title: New recurrent BRCA1/2 mutations in Polish patients with familial breast/ovarian cancer detected by next generation sequencing.
our findings demonstrate that among young Black breast cancer survivors, socioeconomic factors and physician referral patterns contribute to disparities in access to BRCA testing(BRCA1 and BRCA2 mutation detection)
Title: Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer.
Two novel heterozygous mutations predicted to alter the function of PALB2 were identified (c.2014G>C, p.E672Q and c.2993G>A, p.G998E). Notably, both of these mutations co-existed in BRCA1 and BRCA2 families
Title: Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.

Submit: New GeneRIF Correction See all (894)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in BRCA2 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Breast-ovarian cancer, familial 2 MedGen: C2675520 OMIM: 612555 GeneReviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer	Compare labs
Familial cancer of breast MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer	Compare labs
Fanconi anemia, complementation group D1 MedGen: C1838457 OMIM: 605724 GeneReviews: Fanconi Anemia	Compare labs
Glioma susceptibility 3 MedGen: C2751641 OMIM: 613029 GeneReviews: Not available	Compare labs
Hereditary breast and ovarian cancer syndrome MedGen: C0677776 GeneReviews: BRCA1 and BRCA2 Hereditary Breast/Ovarian Cancer	Compare labs
Malignant tumor of prostate MedGen: C0376358 OMIM: 176807 GeneReviews: Not available	Compare labs
Medulloblastoma MedGen: C0025149 OMIM: 155255 GeneReviews: Not available	Compare labs
Pancreatic cancer 2 MedGen: C3150546 OMIM: 613347 GeneReviews: Not available	Compare labs
Tracheoesophageal fistula MedGen: C1861028 OMIM: 189960 GeneReviews: Esophageal Atresia/Tracheoesophageal Fistula Overview	Compare labs
Wilms tumor 1 MedGen: CN033288 OMIM: 194070 GeneReviews: Wilms Tumor Overview, Aniridia	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated (2012-07-06) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated (2012-07-06) ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
FOXM1 transcription factor network, organism-specific biosystem
FOXM1 transcription factor network
Fanconi anemia pathway, organism-specific biosystem (from KEGG)
Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
Fanconi anemia pathway, conserved biosystem (from KEGG)
Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystem (from REACTOME)
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA), organism-specific biosystemHomology directed repair (HDR) of replication-independent DNA double strand breaks (DSBs) via homologous recombination repair (HRR) or single strand annealing (SSA) requires the activation of ATM fol...
HDR through Homologous Recombination (HRR), organism-specific biosystem (from REACTOME)
HDR through Homologous Recombination (HRR), organism-specific biosystemHomology directed repair (HDR) through homologous recombination is known as homologous recombination repair (HRR). HRR occurs after extensive resection of DNA double strand break (DSB) ends, which cr...
Homologous DNA Pairing and Strand Exchange, organism-specific biosystem (from REACTOME)
Homologous DNA Pairing and Strand Exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from 3'-ssDNA overhangs created by extensive resection of DNA double strand break (DSB) ends. R...
Homologous recombination, organism-specific biosystem (from WikiPathways)
Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
Homologous recombination, organism-specific biosystem (from KEGG)
Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Homologous recombination, conserved biosystem (from KEGG)
Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Homology Directed Repair, organism-specific biosystem (from REACTOME)
Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
Meiosis, organism-specific biosystem (from REACTOME)
Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
Meiotic recombination, organism-specific biosystem (from REACTOME)
Meiotic recombination, organism-specific biosystemMeiotic recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity (reviewed in Handel and Schimenti 2010, Inagaki et al. 2010, Cohen et al. 2006). Ther...
Pancreatic cancer, organism-specific biosystem (from KEGG)
Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pancreatic cancer, conserved biosystem (from KEGG)
Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystem (from REACTOME)
Presynaptic phase of homologous DNA pairing and strand exchange, organism-specific biosystemThe presynaptic phase of homologous DNA pairing and strand exchange during homologous recombination repair (HRR) begins with the displacement of RPA from ssDNA (Thompson and Limoli 2003) by the joint...
Resolution of D-Loop Structures, organism-specific biosystem (from REACTOME)
Resolution of D-Loop Structures, organism-specific biosystemOnce repair synthesis has occurred, the D-loop structure may be resolved either through Holliday junction intermediates or through synthesis-dependent strand-annealing (SDSA) (Prado and Aguilera 2003...
Resolution of D-loop Structures through Holliday Junction Intermediates, organism-specific biosystem (from REACTOME)
Resolution of D-loop Structures through Holliday Junction Intermediates, organism-specific biosystemD-loops generated after strand invasion and DNA repair synthesis during homologous recombination repair (HRR) can be resolved through Holliday junction intermediates.A D-loop can be cleaved by the co...
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), organism-specific biosystem (from REACTOME)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), organism-specific biosystemIn the synthesis-dependent strand-annealing (SDSA) model of D-loop resolution, D-loop strands extended by DNA repair synthesis dissociate from their sister chromatid complements and reanneal with the...
Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
Signaling Pathways in Glioblastoma, organism-specific biosystemThe most frequently altered genes in glioblastoma. This pathway originally accompanied the 2008 Nature publication on the comprehensive genomic characterization of human glioblastoma genes and core p...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC13918P2 (e-PCR)
- UniSTS:270878

PMC13918P3 (e-PCR)
- UniSTS:270879

PMC13918P4 (e-PCR)
- UniSTS:270880

PMC13918P5 (e-PCR)
- UniSTS:270881

PMC13918P6 (e-PCR)
- UniSTS:270882

D13S1788 (e-PCR)
- UniSTS:474668

STS-X95157 (e-PCR)
- UniSTS:27960

REN34178 (e-PCR)
- UniSTS:358978

PMC23830P1 (e-PCR)
- UniSTS:272209

G48219 (e-PCR)
- UniSTS:95316

STS-X95152 (e-PCR)
- UniSTS:50804

PMC310899P14 (e-PCR)
- UniSTS:272803

RH68440 (e-PCR)
- UniSTS:34471

BRCA2 (e-PCR)
- UniSTS:505289

SHGC-81356 (e-PCR)
- UniSTS:103159

Homology

Homologs of the BRCA2 gene: The BRCA2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Orthologs from Annotation Pipeline: 176 organisms have orthologs with human gene BRCA2
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
H3 histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
H4 histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
gamma-tubulin binding	IPI Inferred from Physical Interaction more info	PubMed
NOT histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
protease binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IEA Inferred from Electronic Annotation more info
DNA repair	TAS Traceable Author Statement more info
brain development	IEA Inferred from Electronic Annotation more info
cell aging	IEA Inferred from Electronic Annotation more info
centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
chromosome breakage	IEA Inferred from Electronic Annotation more info
cytokinesis	IDA Inferred from Direct Assay more info	PubMed
double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
double-strand break repair	TAS Traceable Author Statement more info
double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
double-strand break repair via homologous recombination	TAS Traceable Author Statement more info
double-strand break repair via synthesis-dependent strand annealing	TAS Traceable Author Statement more info
establishment of protein localization to telomere	IDA Inferred from Direct Assay more info	PubMed
female gonad development	IEA Inferred from Electronic Annotation more info
hemopoiesis	IEA Inferred from Electronic Annotation more info
histone H3 acetylation	IDA Inferred from Direct Assay more info	PubMed
histone H4 acetylation	IDA Inferred from Direct Assay more info	PubMed
homologous chromosome orientation involved in meiotic metaphase I plate congression	IEA Inferred from Electronic Annotation more info
homologous recombination-dependent replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
inner cell mass cell proliferation	IEA Inferred from Electronic Annotation more info
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
male meiosis I	IEA Inferred from Electronic Annotation more info
mammary gland development	IEA Inferred from Electronic Annotation more info
multicellular organism growth	IEA Inferred from Electronic Annotation more info
negative regulation of mammary gland epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
oocyte maturation	IEA Inferred from Electronic Annotation more info
positive regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
replication fork protection	IEA Inferred from Electronic Annotation more info
response to UV-C	IEA Inferred from Electronic Annotation more info
response to X-ray	IEA Inferred from Electronic Annotation more info
response to estradiol	IEA Inferred from Electronic Annotation more info
response to gamma radiation	IEA Inferred from Electronic Annotation more info
response to nutrient	IEA Inferred from Electronic Annotation more info
spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
BRCA2-MAGE-D1 complex	IDA Inferred from Direct Assay more info	PubMed
centrosome	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info
nuclear chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
protein complex	IDA Inferred from Direct Assay more info	PubMed
secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: breast cancer type 2 susceptibility protein

Names: BRCA1/BRCA2-containing complex, subunit 2; Fanconi anemia group D1 protein; breast and ovarian cancer susceptibility gene, early onset; breast and ovarian cancer susceptibility protein 2; breast cancer 2 tumor suppressor; breast cancer 2, early onset; mutant BRCA2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012772.3 RefSeqGene

Range

5001..89193

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_293

mRNA and Protein(s)

NM_000059.3 → NP_000050.2 breast cancer type 2 susceptibility protein

See identical proteins and their annotated locations for NP_000050.2

Status: REVIEWED

Source sequence(s)

AL137247, AL445212, U43746

Consensus CDS

CCDS9344.1

UniProtKB/Swiss-Prot

P51587

Related

ENSP00000369497, OTTHUMP00000018803, ENST00000380152, OTTHUMT00000046000

Conserved Domains (5) summary

pfam09169
Location:2479 → 2667

BRCA-2_helical; BRCA2, helical

pfam00634
Location:1517 → 1550

BRCA2; BRCA2 repeat

cd04493
Location:2682 → 2794

BRCA2DBD_OB1; BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cd04494
Location:2804 → 3054

BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cd04495
Location:3073 → 3167

BRCA2DBD_OB3; BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p2 Primary Assembly

Range

32314862..32399850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011535203.1 → XP_011533505.1

Conserved Domains (5) summary

pfam09169
Location:2479 → 2667

BRCA-2_helical; BRCA2, helical

pfam00634
Location:1517 → 1550

BRCA2; BRCA2 repeat

cd04493
Location:2682 → 2794

BRCA2DBD_OB1; BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cd04494
Location:2804 → 3054

BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cd04495
Location:3073 → 3167

BRCA2DBD_OB3; BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
XM_011535204.1 → XP_011533506.1

Conserved Domains (5) summary

pfam09169
Location:2447 → 2635

BRCA-2_helical; BRCA2, helical

pfam00634
Location:1517 → 1550

BRCA2; BRCA2 repeat

cd04493
Location:2650 → 2762

BRCA2DBD_OB1; BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cd04494
Location:2772 → 3022

BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cd04495
Location:3041 → 3135

BRCA2DBD_OB3; BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
XM_011535205.1 → XP_011533507.1

Conserved Domains (4) summary

pfam09169
Location:2479 → 2667

BRCA-2_helical; BRCA2, helical

pfam00634
Location:1517 → 1550

BRCA2; BRCA2 repeat

cd04493
Location:2682 → 2794

BRCA2DBD_OB1; BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

cl09930
Location:2804 → 2918

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.