U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc47a1 solute carrier family 47, member 1 [ Mus musculus (house mouse) ]

Gene ID: 67473, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc47a1provided by MGI
Official Full Name
solute carrier family 47, member 1provided by MGI
Primary source
MGI:MGI:1914723
See related
Ensembl:ENSMUSG00000010122 AllianceGenome:MGI:1914723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MATE1; mMATE1; 1300013J15Rik
Summary
Predicted to enable L-arginine transmembrane transporter activity; amide transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Predicted to be involved in L-arginine import across plasma membrane; organic cation transport; and xenobiotic transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and vesicle. Predicted to be active in membrane. Is expressed in several structures, including liver; lung; metanephros; nervous system; and spleen. Orthologous to human SLC47A1 (solute carrier family 47 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 97.2), liver adult (RPKM 32.0) and 3 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc47a1 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61234226..61269668, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61343400..61378842, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12 Neighboring gene STARR-seq mESC enhancer starr_29676 Neighboring gene predicted gene, 42081 Neighboring gene STARR-positive B cell enhancer ABC_E6994 Neighboring gene nuclear encoded tRNA trytophan 5 (anticodon CCA)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity. Waissbluth S, et al. Acta Otolaryngol, 2023 Mar. PMID 36943799
  2. MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia. Uddin ME, et al. Int J Mol Sci, 2022 Aug 3. PMID 35955741, Free PMC Article
  3. Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease. Liu H, et al. Nat Genet, 2022 Jul. PMID 35710981
  4. Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse. Shingaki T, et al. Pharm Res, 2015 Aug. PMID 25715695
  5. The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo. Hume WE, et al. Bioorg Med Chem, 2013 Dec 15. PMID 24238901

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
    Title: MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity.
  2. The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
    Title: The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
  3. Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
    Title: Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
  4. Tissue concentration based investigations using [(11)C]metformin by PET enables the functional analysis of MATEs in the liver and kidneys
    Title: Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C]Metformin in Mouse.
  5. Mate1 mRNA expression was decreased in mice with either the ob/ob model or the methionine/choline deficiency model of nonalcoholic steatohepatitis.
    Title: Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
  6. MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine.
    Title: Multidrug and toxic compound extrusion protein-1 (MATE1/SLC47A1) is a novel flavonoid transporter.
  7. [(11)C]Metformin may be useful as a PET probe to non-invasively study the in vivo function of hepatobiliary transport and drug-drug interactions, mediated by MATE1 in future clinical investigations.
    Title: The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.
  8. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
    Title: Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein.
  9. Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis.
    Title: Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.
  10. MATE1 mediates the efflux of cisplatin and is involved in cisplatin-induced nephrotoxicity.
    Title: Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables polyspecific organic cation:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyspecific organic cation:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables putrescine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables thiamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organic cation transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
multidrug and toxin extrusion protein 1
Names
MATE-1
mMATE-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026183.5 → NP_080459.2  multidrug and toxin extrusion protein 1

    See identical proteins and their annotated locations for NP_080459.2

    Status: VALIDATED

    Source sequence(s)
    AK009038, BB556514, BB661673, BY006577
    Consensus CDS
    CCDS24811.2
    UniProtKB/Swiss-Prot
    Q5SS45, Q8K0H1, Q9CQ64
    Related
    ENSMUSP00000010267.4, ENSMUST00000010267.10
    Conserved Domains (1) summary
    cd13132
    Location:34 → 468
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61234226..61269668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249188.3 → XP_011247490.1  multidrug and toxin extrusion protein 1 isoform X2

    Conserved Domains (1) summary
    cd13132
    Location:1 → 418
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

  2. XM_006533993.2 → XP_006534056.1  multidrug and toxin extrusion protein 1 isoform X1

    Conserved Domains (1) summary
    cd13132
    Location:70 → 492
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

  3. XM_036156909.1 → XP_036012802.1  multidrug and toxin extrusion protein 1 isoform X4

    Conserved Domains (1) summary
    cd13132
    Location:22 → 308
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

  4. XM_036156910.1 → XP_036012803.1  multidrug and toxin extrusion protein 1 isoform X4

    Conserved Domains (1) summary
    cd13132
    Location:22 → 308
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

  5. XM_011249189.4 → XP_011247491.1  multidrug and toxin extrusion protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011247491.1

    UniProtKB/Swiss-Prot
    Q8K0H1
    Conserved Domains (1) summary
    cd13132
    Location:40 → 326
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

  6. XM_006533995.4 → XP_006534058.1  multidrug and toxin extrusion protein 1 isoform X5

    Conserved Domains (1) summary
    cd13132
    Location:1 → 280
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RNA

  1. XR_003949493.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0H1.2 GenPept UniProtKB/Swiss-Prot:Q8K0H1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous