SSB Sjogren syndrome antigen B (autoantigen La) [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: SSBprovided by HGNC
Official Full Name: Sjogren syndrome antigen B (autoantigen La)provided by HGNC
Primary source: HGNC:11316
See related: Ensembl:ENSG00000138385; HPRD:00168; MIM:109090; Vega:OTTHUMG00000132212
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: La; LARP3
Summary: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. [provided by RefSeq, Nov 2011]

Help top of page

Genomic context

Location :: 2q31.1

Sequence :: Chromosome: 2; NC_000002.11 (170655389..170668575)

See SSB in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data indicate that the JAK2(V617F) mutation affects p53 response to DNA damage through the upregulation of La antigen and accumulation of MDM2
Title: JAK2(V617F) negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative neoplasms.
the structural elements required for La-mediated RNA chaperone activity
Title: RNA chaperone activity of human La protein is mediated by variant RNA recognition motif.
La binds to domain IV of the hepatitis C virus RNA using an RNA recognition that is quite distinct from its mode of binding to RNAs with a 3' UUU(OH) trailer.
Title: Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.
function of the RNA-binding protein La in promoting tumor progression of head and neck squamous cell carcinoma
Title: Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.
Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RNA-induced silencing complex catalysis.
Title: Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RISC catalysis.
Overexpression of mouse or human La enhanced M-MuLV particle release in the absence of glycosylated gag.
Title: The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag.
La protein binds to and mediates interaction of the 5' and 3' noncoding ends of the Japanese encephalitis virus genome.
Title: La protein can simultaneously bind to both 3'- and 5'-noncoding regions of Japanese encephalitis virus genome.
show elevated La protein expression in cervical cancer tissue and its correlation with aberrant CCND1 protein levels in cervical tumor tissue lysates
Title: The RNA-binding protein La contributes to cell proliferation and CCND1 expression.
conclude that RNPs containing hY RNAs and Ro60, La or nucleolin are not required for the function of hY RNAs in chromosomal DNA replication in a human cell-free system, which can be mediated by Y RNAs outside of these RNPs
Title: Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication.
There is a correlation between La protein and HBV mRNA and the expression of HBV protein.
Title: [A study on the relativity between La protein and the stability of HBV mRNA and the expression of HBV protein].

Submit: New GeneRIF Correction See all (50)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	The La autoantigen binds to HIV-1 TAR RNA and alleviates translational repression by the HIV-1 leader RNA, suggesting a possible involvement of the La autoantigen in HIV-1 gene expression and Tat transactivation	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_003133.1	NP_671491.1	HCVgp1	BIND	PubMed	NS5A interacts with La.
NP_003133.1		SNORD3A	BIND	PubMed	La interacts with U3 snoRNA
NP_003133.1	AAK01233.1		BIND	PubMed	La interacts with Dengue type 4 NS3.
NP_003133.1	AAK01233.1		BIND	PubMed	La interacts with Dengue type 4 NS5.
NP_003133.1	AF011751.1		BIND	PubMed	La interacts with HCV 3' UTR.
NP_003133.1	AF011751.1		BIND	PubMed	La interacts with HCV 5'UTR.
NP_003133.1	AF326573.1		BIND	PubMed	La interacts with Dengue 4 Virus 5' UTR.
NP_003133.1	AF326573.1		BIND	PubMed	La interacts with Dengue 4 Virus 3' UTR.
NP_003133.1			BIND	PubMed	DEN4 3'UTR(-) interacts with La.
P05455	P19338	NCL	HPRD	PubMed
P05455	P05455	SSB	HPRD	PubMed
BioGRID:112619	BioGRID:221164	Clp1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:111596	EIF2AK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:108325	EMD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:109318	HDGF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:228787	Mical3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:110771	NCL	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:112619	BioGRID:203509	Nhp2l1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:115897	PMVK	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:116502	PUF60	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:112734	TADA2A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112619	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:112619	BioGRID:204613	Ybx1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
mRNA binding	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
tRNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
RNA processing	IEA Inferred from Electronic Annotation more info
histone mRNA metabolic process	TAS Traceable Author Statement more info	PubMed
tRNA modification	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info
ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: lupus La protein

Names: lupus La protein; SS-B; autoantigen La; la autoantigen; SS-B/La protein; lupus La antigen; sjoegren syndrome type B antigen; La ribonucleoprotein domain family, member 3

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030640.1 RefSeqGene

Range

5001..18253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003142.4 → NP_003133.1 lupus La protein

Status: REVIEWED

Source sequence(s)

BC001289, CD676196

Consensus CDS

CCDS2237.1

UniProtKB/Swiss-Prot

P05455

Related

ENSP00000260956, OTTHUMP00000163067, ENST00000260956, OTTHUMT00000255270

Conserved Domains (3) summary

cd00590
Location:112 – 169
Blast Score: 127

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

cd08028
Location:10 – 91
Blast Score: 376

LARP_3; La RNA-binding domain of La-related protein 3

cl02586
Location:231 – 327
Blast Score: 234

RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

170655389..170668575

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

162543442..162556637

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009967.8	AAY14868.1
genomic	CH471058.2	EAX11256.1
		EAX11257.1
		EAX11258.1
		EAX11259.1
mRNA	AB451228.1	BAG70042.1
mRNA	AB451351.1	BAG70165.1
mRNA	BC001289.1	AAH01289.1
mRNA	BC020818.1	AAH20818.1
mRNA	BT009862.1	AAP88864.1
mRNA	CD676196.1	None
mRNA	D28394.1	BAA05760.1
mRNA	DQ185046.1	ABD14426.1
mRNA	J04205.1	AAA51885.1
mRNA	M20328.1	AAA36577.1
mRNA	M35261.1	AAA36652.1
mRNA	M35262.1	AAA36654.1
mRNA	M35263.1	AAA36653.1
mRNA	X13697.1	CAA31985.1
mRNA	X14684.1	CAA32815.1
mRNA	X69804.1	None
other-genetic	DQ894459.2	ABM85385.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P05455.2	GenPept	UniProtKB/Swiss-Prot:P05455
Q14730	GenPept	UniProtKB/TrEMBL:Q14730
Q2F832	GenPept	UniProtKB/TrEMBL:Q2F832
Q9UMH5	GenPept	UniProtKB/TrEMBL:Q9UMH5
Q9UMH6	GenPept	UniProtKB/TrEMBL:Q9UMH6
Q9UMH7	GenPept	UniProtKB/TrEMBL:Q9UMH7