Srpr signal recognition particle receptor ('docking protein') [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Srprprovided by MGI
Official Full Name: signal recognition particle receptor ('docking protein')provided by MGI
Primary source: MGI:1914648
See related: Ensembl:ENSMUSG00000032042; Vega:OTTMUSG00000031587
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D11Mgi27; 1300011P19Rik

Genomic context

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Location :: 9; 9 A5.3

Sequence :: Chromosome: 9; NC_000075.6 (35211203..35217003)

See Srpr in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from BioSystems

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Activation of Chaperone Genes by XBP1(S), organism-specific biosystem (from REACTOME)
Activation of Chaperone Genes by XBP1(S), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of Chaperones by IRE1alpha, organism-specific biosystem (from REACTOME)
Activation of Chaperones by IRE1alpha, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein export, organism-specific biosystem (from KEGG)
Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
Protein export, conserved biosystem (from KEGG)
Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Unfolded Protein Response, organism-specific biosystem (from REACTOME)
Unfolded Protein Response, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

GDB:197863 (e-PCR)
- UniSTS:155977

UniSTS:236630 (e-PCR)
- UniSTS:236630

NoName (e-PCR)
- UniSTS:236631

Homology

Homologs of the Srpr gene: The Srpr gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleoside-triphosphatase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
signal recognition particle binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
GTP catabolic process	IEA Inferred from Electronic Annotation more info
SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
intracellular protein transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
signal recognition particle receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal recognition particle receptor subunit alpha

Names: signal recognition particle receptor subunit alpha; DP-alpha; SR-alpha; docking protein alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026130.1 → NP_080406.1 signal recognition particle receptor subunit alpha

Status: PROVISIONAL

Source sequence(s)

AK004967

Consensus CDS

CCDS22959.1

UniProtKB/Swiss-Prot

Q9DBG7

Related

ENSMUSP00000034541, OTTMUSP00000041581, ENSMUST00000034541, OTTMUST00000078230

Conserved Domains (4) summary

cd03115
Location:417 – 613
Blast Score: 518

SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...

pfam04086
Location:26 – 286
Blast Score: 610

SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal

smart00962
Location:416 – 635
Blast Score: 541

SRP54; SRP54-type protein, GTPase domain

smart00963
Location:322 – 395
Blast Score: 127

SRP54_N; SRP54-type protein, helical bundle domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

35211203..35217003

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

32447922..32453726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01077101.1 (44610..50414)	None
genomic	AC140448.3 (10681..16481)	None
mRNA	AK004967.2	BAB23706.1	C57BL/6J
mRNA	AK007516.1	BAB25084.1	C57BL/6J
mRNA	AK038017.1	BAC29922.1	C57BL/6J
mRNA	AK177061.1	None
mRNA	AK183434.1	None
mRNA	AK194804.1	None
mRNA	AK198440.1	None
mRNA	AK199987.1	None
mRNA	AK201921.1	None
mRNA	AK206633.1	None
mRNA	AK219602.1	None
mRNA	BC012512.1	AAH12512.1	FVB/N
mRNA	BC021839.1	AAH21839.1	FVB/N
mRNA	FJ859040.1	ACP03808.1	CAST/EiJ