Jam2 junction adhesion molecule 2 [Mus musculus] - Gene

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Summary

Official Symbol: Jam2provided by MGI
Official Full Name: junction adhesion molecule 2provided by MGI
Primary source: MGI:1933820
Locus tag: RP23-253E17.2
See related: Ensembl:ENSMUSG00000053062; Vega:OTTMUSG00000025168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JAM-2; JAM-B; Jcam2; VE-JAM; 1110002N23Rik; 2410030G21Rik; 2410167M24Rik

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Genomic context

Location :: 16 C3.3; 16

Sequence :: Chromosome: 16; NC_000082.6 (84774123..84826380)

See Jam2 in Epigenomics, MapViewer

Chromosome 16 - NC_000082.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JAM-B is an active player in the maintenance of the bone marrow stromal microenvironment.
Title: JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow.
IL-1alpha and TGF-beta2 regulate JAM-B expression in an opposite manner in sertoli cells.
Title: Opposite effects of interleukin-1alpha and transforming growth factor-beta2 induce stage-specific regulation of junctional adhesion molecule-B gene in Sertoli cells.
JAM-B identifies a unique population of RGCs in which structure corresponds remarkably to function
Title: Molecular identification of a retinal cell type that responds to upward motion.
These results demonstrate that Jam-B is dispensable for normal mouse development and stem cell identity in embryonic, neural, and hematopoietic stem cells.
Title: Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.
promotes lymphocyte transendothelial migration
Title: Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration.
Interactions with JAM-B and -C are essential for development of cutaneous inflammation.
Title: Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation.
Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells.
Title: Junctional adhesion molecules and interendothelial junctions.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

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Function	Evidence Code	Pubs
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
negative regulation of cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
tight junction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: junctional adhesion molecule B

Names: junctional adhesion molecule B; junction adhesion molecule B; junctional adhesion molecule 2; junction cell adhesion molecule 2; vascular endothelial junction-associated molecule

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023844.5 → NP_076333.3 junctional adhesion molecule B precursor

Status: VALIDATED

Source sequence(s)

AC164162, BC028778

Consensus CDS

CCDS37381.1

UniProtKB/Swiss-Prot

Q9JI59

Related

ENSMUSP00000109833, OTTMUSP00000030469, ENSMUST00000114195, OTTMUST00000061926

Conserved Domains (2) summary

cd00096
Location:152 – 221
Blast Score: 129

Ig; Immunoglobulin domain

smart00406
Location:47 – 112
Blast Score: 87

IGv; Immunoglobulin V-Type

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000082.6 Reference GRCm38 C57BL/6J

Range

84774123..84826380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000038.1 Alternate Mm_Celera

Range

84978233..85031772

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC164162.2 (47510..83273)	None
genomic	CH466521.1	EDK98313.1	mixed
genomic	CT027693.11	CAO78081.1
		CAO78082.1
genomic	CT027693.11	CAO78081.1
		CAO78082.1
mRNA	AF255911.1	AAF81224.1	C57BL/6J
mRNA	AJ291757.1	CAC20699.1
mRNA	AK010616.1	BAB27064.1	C57BL/6J
mRNA	AK010826.1	BAB27208.1	C57BL/6J
mRNA	AK013914.1	BAB29053.1	C57BL/6J
mRNA	AK028757.1	BAC26102.1	C57BL/6J
mRNA	AK045095.1	BAC32219.1	C57BL/6J
mRNA	AK078128.1	BAC37139.1	C57BL/6J
mRNA	AK153636.1	None	C57BL/6J
mRNA	BC028778.1	AAH28778.1	C57BL/6J