TRIM21 tripartite motif containing 21 [Homo sapiens] - Gene

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Summary

Official Symbol: TRIM21provided by HGNC
Official Full Name: tripartite motif containing 21provided by HGNC
Primary source: HGNC:11312
See related: Ensembl:ENSG00000132109; HPRD:00170; MIM:109092; Vega:OTTHUMG00000165701
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SSA; RO52; SSA1; RNF81
Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 11p15.5

Sequence :: Chromosome: 11; NC_000011.9 (4406127..4414926, complement)

See TRIM21 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.
Title: SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production.
anti-Ro52 autoantibodies binding the RING domain of Ro52 may be actively involved in the pathogenesis of rheumatic autoimmune disease by inhibiting Ro52-mediated ubiquitination.
Title: Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.
FADD and TRIM21 together negatively regulate the late IFN-alpha pathway in response to viral infection.
Title: Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production.
60 kD Ro and nRNP A frequently initiate human lupus autoimmunity
Title: 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.
Cells possess a cytosolic IgG receptor, tripartite motif-containing 21 (TRIM21), which binds to antibodies with a higher affinity than any other IgG receptor in the human body.
Title: Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).
Results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation.
Title: Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.
Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Ro52-mediated monoubiquitination is involved in the subcellular translocation of active IKK beta to autophagosomes.
Title: Downregulation of active IKK beta by Ro52-mediated autophagy.
Importantly, the Ro52 cytoplasmic bodies are highly motile and are located along the microtubule network. These results suggest that the Ro52 cytoplasmic bodies are unidentified structures that are transported along the microtubule network.
Title: Dynamic movements of Ro52 cytoplasmic bodies along microtubules.
Ro52 down-regulates Tax-induced NF-kappaB signalling by monoubiquitinating IKKbeta and by reducing the level of Tax
Title: Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling.

Submit: New GeneRIF Correction See all (36)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	The RING domain of TRIM21 can functionally replace the corresponding domain of rhesus monkey TRIM5alpha with respect to inhibition of HIV-1 infection through the binding of the chimeras to HIV-1 capsid complexes	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P19474	Q9GZT8	NIF3L1	HPRD	PubMed
P19474	P19474	TRIM21	HPRD	PubMed
P19474	P10155	TROVE2	HPRD	PubMed
P19474	Q13107	USP4	HPRD	PubMed
P19474	P63104	YWHAZ	HPRD	PubMed
BioGRID:112615	BioGRID:106821	APC	BioGRID	PubMed	Two-hybrid
BioGRID:112615	BioGRID:107461	CDKN1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112615	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:112615	BioGRID:128177	EIF2C3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:128178	EIF2C4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:114302	FADD	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112615	BioGRID:116887	FBXW11	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112615	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:109368	HLA-DRB1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:112615	BioGRID:109767	IKBKB	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112615	BioGRID:109869	IRF3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112615	BioGRID:109873	IRF7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112615	BioGRID:109621	IRF8	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112615	BioGRID:114200	NCOA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:113841	NCOA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:121922	NIF3L1	BioGRID	PubMed	Two-hybrid
BioGRID:112615	BioGRID:112391	SKP1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:112615	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:112615	BioGRID:114397	SQSTM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112615	BioGRID:112615	TRIM21	BioGRID	PubMed	Biochemical Activity; Two-hybrid
BioGRID:112615	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112615	BioGRID:116078	USP19	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:113221	USP4	BioGRID	PubMed	Biochemical Activity; Two-hybrid
BioGRID:112615	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112615	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
RNA binding	IEA Inferred from Electronic Annotation more info
ligase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein trimerization	IDA Inferred from Direct Assay more info	PubMed
protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic mRNA processing body	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase TRIM21

Names: E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003141.3 → NP_003132.2 E3 ubiquitin-protein ligase TRIM21

Status: REVIEWED

Source sequence(s)

AW575137, BC010861, BP280435, BP288941, BU594670

Consensus CDS

CCDS44525.1

UniProtKB/Swiss-Prot

P19474

Related

ENSP00000254436, OTTHUMP00000230775, ENST00000254436, OTTHUMT00000385842

Conserved Domains (6) summary

cd00021
Location:91 – 128
Blast Score: 105

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:15 – 58
Blast Score: 138

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam12128
Location:115 – 235
Blast Score: 88

DUF3584; Protein of unknown function (DUF3584)

pfam13923
Location:12 – 56
Blast Score: 130

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl02614
Location:339 – 465
Blast Score: 368

SPRY; SPRY domain

cl02686
Location:286 – 337
Blast Score: 232

PRY; SPRY-associated domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

4406127..4414926, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

4064388..4073231, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009758.8 (111285..120084)	None
genomic	AF391283.1	AAK76432.1
genomic	CH471064.2	EAW68845.1
genomic	FB775520.1	CAV30717.1
genomic	U01882.1	AAB87094.1
genomic	U13657.1	AAA79867.1
genomic	U13658.1	AAA79867.1
mRNA	AK225564.1	None
mRNA	AW575137.1	None
mRNA	AY742713.1	AAU89982.1
mRNA	BC010861.1	AAH10861.1
mRNA	BP280435.1	None
mRNA	BP288941.1	None
mRNA	BU594670.1	None
mRNA	M34551.1	AAA36581.1
mRNA	M62800.1	AAA36651.1
other-genetic	EU446706.1	ABZ92235.1