SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) [Homo sapiens] - Gene

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Summary

Official Symbol: SRP14provided by HGNC
Official Full Name: signal recognition particle 14kDa (homologous Alu RNA binding protein)provided by HGNC
Primary source: HGNC:11299
See related: Ensembl:ENSG00000140319; HPRD:02831; MIM:600708; Vega:OTTHUMG00000172391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALURBP; MGC14326

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Genomic context

Location :: 15q22

Sequence :: Chromosome: 15; NC_000015.9 (40327891..40331389, complement)

See SRP14 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mutational study on SRP9/14 that identified and characterized regions and single residues essential for elongation arrest activity
Title: Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein.
SRP14 mutant proteins with absence of a peptide elongation delay caused inefficient targeting of preproteins leading to defects in secretion, depletion of proteins in the endogenous membranes, and reduced cell growth.
Title: SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P37108	Q9UNZ2	NSFL1C	HPRD	PubMed
P37108	P49458	SRP9	HPRD	PubMed
BioGRID:112605	BioGRID:107252	CALM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112605	BioGRID:120075	DDX56	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112605	BioGRID:120780	LYAR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112605	BioGRID:115783	NOP56	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112605	BioGRID:215383	Rrp1b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112605	BioGRID:112604	SRP9	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:112605	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
7S RNA binding	IEA Inferred from Electronic Annotation more info
RNA binding	TAS Traceable Author Statement more info	PubMed
endoplasmic reticulum signal peptide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
SRP-dependent cotranslational protein targeting to membrane	TAS Traceable Author Statement more info
cellular protein metabolic process	TAS Traceable Author Statement more info
cotranslational protein targeting to membrane	TAS Traceable Author Statement more info	PubMed
gene expression	TAS Traceable Author Statement more info
negative regulation of translational elongation	IEA Inferred from Electronic Annotation more info
protein targeting to ER	IMP Inferred from Mutant Phenotype more info	PubMed
response to drug	IDA Inferred from Direct Assay more info	PubMed
translation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
signal recognition particle, endoplasmic reticulum targeting	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: signal recognition particle 14 kDa protein

Names: signal recognition particle 14 kDa protein; 18 kDa Alu RNA-binding protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003134.4 → NP_003125.3 signal recognition particle 14 kDa protein

Status: VALIDATED

Source sequence(s)

AB061546, BC035495, CV575824

Consensus CDS

CCDS42017.1

UniProtKB/Swiss-Prot

P37108

Related

ENSP00000267884, OTTHUMP00000248294, ENST00000267884, OTTHUMT00000418262

Conserved Domains (1) summary

pfam02290
Location:4 – 94
Blast Score: 345

SRP14; Signal recognition particle 14kD protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

40327891..40331389, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

17172039..17175465, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC025168.7 (169072..172219)	None
genomic	CH471125.1	EAW92390.1
		EAW92391.1
mRNA	AB061546.1	BAB69067.1
mRNA	AB451391.1	BAG70205.1
mRNA	BC035495.2	AAH35495.1
mRNA	BC051006.1	None
mRNA	BC071716.1	AAH71716.1
mRNA	BC100031.1	AAI00032.1
mRNA	CV575824.1	None
mRNA	U07857.1	AAA59066.1
mRNA	X73459.1	CAA51838.1
other-genetic	HQ447734.1	ADQ32219.1