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SRP9 signal recognition particle 9kDa [ Homo sapiens (human) ]

Gene ID: 6726, updated on 11-Sep-2014
Official Symbol
SRP9provided by HGNC
Official Full Name
signal recognition particle 9kDaprovided by HGNC
Primary source
HGNC:HGNC:11304
See related
Ensembl:ENSG00000143742; HPRD:02830; MIM:600707; Vega:OTTHUMG00000037738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALURBP
See SRP9 in Epigenomics, MapViewer
Location:
1q42.12
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (225777813..225790466)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225965515..225978168)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene enabled homolog (Drosophila) Neighboring gene uncharacterized LOC102723834 Neighboring gene left-right determination factor 2 pseudogene Neighboring gene epoxide hydrolase 1, microsomal (xenobiotic) Neighboring gene transmembrane protein 63A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Downregulation of guanine nucleotide-releasing protein, CD151/PETA-3, neuronatin, neuroendocrine differentiation factor, mitochondria 16s rRNA, and signal recognition particle is observed in HIV-1 infected and HIV-1 gp120-treated astrocytes PubMed
Rev rev HIV-1 Rev interacting protein, signal recognition particle 9kDa (SRP9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SRP9 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, conserved biosystem (from KEGG)
    Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
    SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC110981

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
signal recognition particle binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
negative regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
 
translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
signal recognition particle receptor complex TAS
Traceable Author Statement
more info
PubMed 
signal recognition particle, endoplasmic reticulum targeting NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
signal recognition particle 9 kDa protein
Names
signal recognition particle 9 kDa protein
signal recognition particle 9kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130440.1NP_001123912.1  signal recognition particle 9 kDa protein isoform 1

    See proteins identical to NP_001123912.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    BC021995, DA983529, EF488978
    Consensus CDS
    CCDS44323.1
    UniProtKB/TrEMBL
    A0A024R3P3
    UniProtKB/Swiss-Prot
    P49458
    Related
    ENSP00000355804, OTTHUMP00000035861, ENST00000366839, OTTHUMT00000092055
    Conserved Domains (1) summary
    pfam05486
    Location:451
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)
  2. NM_003133.5NP_003124.1  signal recognition particle 9 kDa protein isoform 2

    See proteins identical to NP_003124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC008443, BC021995, DA983529
    Consensus CDS
    CCDS1546.1
    UniProtKB/Swiss-Prot
    P49458
    Related
    ENSP00000305230, OTTHUMP00000035860, ENST00000304786, OTTHUMT00000092054
    Conserved Domains (1) summary
    pfam05486
    Location:474
    SRP9-21; Signal recognition particle 9 kDa protein (SRP9)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    225777813..225790466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    196483476..196496108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    227237869..227250522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)