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SRM spermidine synthase [ Homo sapiens (human) ]

Gene ID: 6723, updated on 8-May-2016
Official Symbol
SRMprovided by HGNC
Official Full Name
spermidine synthaseprovided by HGNC
Primary source
HGNC:HGNC:11296
See related
Ensembl:ENSG00000116649 HPRD:01692; MIM:182891; Vega:OTTHUMG00000002119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPT; SPS1; SPDSY; SRML1
Summary
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p36-p22
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (11054592..11060034, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11114649..11120091, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TAR DNA binding protein Neighboring gene mannan binding lectin serine peptidase 2 Neighboring gene exosome component 10 Neighboring gene uncharacterized LOC105376736 Neighboring gene mechanistic target of rapamycin Neighboring gene MTOR antisense RNA 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
spermidine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
spermidine synthase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
polyamine metabolic process TAS
Traceable Author Statement
more info
 
spermidine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
spermidine synthase
Names
putrescine aminopropyltransferase
spermidine synthase-1
NP_003123.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003132.2NP_003123.2  spermidine synthase

    See identical proteins and their annotated locations for NP_003123.2

    Status: VALIDATED

    Source sequence(s)
    AL109811, BC000309
    Consensus CDS
    CCDS125.1
    UniProtKB/Swiss-Prot
    P19623
    Related
    ENSP00000366156, OTTHUMP00000002170, ENST00000376957, OTTHUMT00000006056
    Conserved Domains (1) summary
    cd02440
    Location:96206
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    11054592..11060034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    11102556..11108076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)