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Cdt1 chromatin licensing and DNA replication factor 1 [ Mus musculus (house mouse) ]

Gene ID: 67177, updated on 8-May-2016
Official Symbol
Cdt1provided by MGI
Official Full Name
chromatin licensing and DNA replication factor 1provided by MGI
Primary source
MGI:MGI:1914427
See related
Ensembl:ENSMUSG00000006585
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ris2; C76791; AW545653; 2610318F11Rik
Orthologs
Location:
8; 8 E1
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (122568015..122573130)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (125091915..125097030)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene piezo-type mechanosensitive ion channel component 1 Neighboring gene predicted gene, 34847 Neighboring gene adenine phosphoribosyl transferase Neighboring gene galactosamine (N-acetyl)-6-sulfate sulfatase Neighboring gene predicted gene, 34962

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication checkpoint ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA-dependent DNA replication initiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA-dependent DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
regulation of nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
DNA replication factor Cdt1
Names
DUP
cdt1
double parked homolog
retroviral insertion site 2 protein
retroviral integration site 1
retroviral integration site 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026014.3NP_080290.3  DNA replication factor Cdt1

    See identical proteins and their annotated locations for NP_080290.3

    Status: PROVISIONAL

    Source sequence(s)
    BC048076
    Consensus CDS
    CCDS22741.1
    UniProtKB/Swiss-Prot
    Q8R4E9
    Related
    ENSMUSP00000006760, ENSMUST00000006760
    Conserved Domains (2) summary
    cd08674
    Location:181364
    Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
    cd08767
    Location:427549
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    122568015..122573130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    126797613..126802728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)