SRI sorcin [Homo sapiens] - Gene

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Summary

Official Symbol: SRIprovided by HGNC
Official Full Name: sorcinprovided by HGNC
Primary source: HGNC:11292
See related: Ensembl:ENSG00000075142; HPRD:01680; MIM:182520; Vega:OTTHUMG00000157267
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCN; V19; CP22; CP-22; FLJ26259
Summary: This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

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Genomic context

Location :: 7q21.1

Sequence :: Chromosome: 7; NC_000007.13 (87834432..87856308, complement)

See SRI in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

sorcin retains ChREBP in the cytosol at low glucose concentrations and may act as a Ca(2+) sensor for glucose-induced nuclear translocation and the activation of ChREBP-dependent genes.
Title: Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells.
Data show that colorectal cancer cells overexpress sorcin as an adaptive mechanism to prevent endoplasmic reticulum stress and escape apoptosis triggered by chemotherapeutic agents.
Title: Sorcin induces a drug-resistant phenotype in human colorectal cancer by modulating Ca(2+) homeostasis.
Upregulation of sorcin is associated with gastric cancer.
Title: Upregulation of soluble resistance-related calcium-binding protein (sorcin) in gastric cancer.
Overexpression of sorcin by gene transfection was able to confer drug resistance in gastric cancer cells
Title: Overexpression of sorcin results in multidrug resistance in gastric cancer cells with up-regulation of P-gp.
Overexpression of sorcin was associated with gemcitabine resistance in non-small cell lung cancer.
Title: Comparative proteomic profiling identified sorcin being associated with gemcitabine resistance in non-small cell lung cancer.
The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane.
Title: Echinophilic proteins stomatin, sorcin, and synexin locate outside gangliosideM1 (GM1) patches in the erythrocyte membrane.
Depletion of TRAP1 by short hairpin RNA in colorectal carcinoma cells lowered Sorcin levels in mitochondria, whereas the depletion of Sorcin by small interfering RNA increased TRAP1 degradation.
Title: Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Overexpression of sorcin could induce low level of multidrug resistant (MDR) in SGC7901 cells, indicating that sorcin is associated with MDR of SGC7901 cells.
Title: [Correlation of sorcin overexpression to multidrug resistance of human gastric cancer cell line SGC7901].

Submit: New GeneRIF Correction See all (21)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P30626	P50995	ANXA11	HPRD	PubMed
P30626	P20073	ANXA7	HPRD	PubMed
P30626	Q13936	CACNA1C	HPRD	PubMed
P30626	Q13698	CACNA1S	HPRD	PubMed
P30626	NDP52	CALCOCO2	HPRD	PubMed
P30626	P28676	GCA	HPRD	PubMed
P30626	P49810	PSEN2	HPRD	PubMed
P30626	Q92736	RYR2	HPRD	PubMed
P30626	P04278	SHBG	HPRD	PubMed
P30626	Q15796	SMAD2	HPRD	PubMed
P30626	P30626	SRI	HPRD	PubMed
BioGRID:112595	BioGRID:124493	ALG2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112595	BioGRID:106807	ANXA7	BioGRID	PubMed	Co-purification; Far Western
BioGRID:112595	BioGRID:107229	CACNA1C	BioGRID	PubMed	Reconstituted Complex
BioGRID:112595	BioGRID:107233	CACNA1S	BioGRID	PubMed	Reconstituted Complex
BioGRID:112595	BioGRID:115535	CALCOCO2	BioGRID	PubMed	Two-hybrid
	NP_036330.1	GCA	BIND	PubMed	Sorcin interacts with grancalcin to form a heterodimer.
BioGRID:112595	BioGRID:117333	GCA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112595	BioGRID:110952	NRAS	BioGRID	PubMed	Two-hybrid
BioGRID:112595	BioGRID:111643	PSEN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112595	BioGRID:114166	RUVBL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112595	BioGRID:112174	RYR2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112595	BioGRID:112595	SRI	BioGRID	PubMed	Co-crystal Structure; Two-hybrid
BioGRID:112595	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
calcium channel regulator activity	TAS Traceable Author Statement more info	PubMed
calcium ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
calcium ion transport	IEA Inferred from Electronic Annotation more info
heart development	TAS Traceable Author Statement more info	PubMed
intracellular sequestering of iron ion	TAS Traceable Author Statement more info	PubMed
muscle organ development	TAS Traceable Author Statement more info	PubMed
regulation of action potential	TAS Traceable Author Statement more info	PubMed
regulation of heart contraction	TAS Traceable Author Statement more info	PubMed
regulation of striated muscle contraction	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Z disc	IEA Inferred from Electronic Annotation more info
cytoplasm	TAS Traceable Author Statement more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: sorcin

Names: sorcin; H_RG167B05.1; 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032138.1 RefSeqGene

Range

5001..26877

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256891.1 → NP_001243820.1 sorcin isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. These differences result in a protein (isoform C) with a shorter and distinct C-terminus, compared to isoform A.

Source sequence(s)

AK296601, BI524104, DA268050

Conserved Domains (3) summary

cd00051
Location:75 – 130
Blast Score: 113

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:111 – 163
Blast Score: 101

EF_hand_5; EF-hand domain pair

pfam13833
Location:45 – 102
Blast Score: 136

EF_hand_6; EF-hand domain pair
NM_001256892.1 → NP_001243821.1 sorcin isoform D

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in a protein (isoform D) with shorter and distinct N- and C-termini, compared to isoform A.

Source sequence(s)

AK296601, BM739144

UniProtKB/TrEMBL

B4DKK2

Conserved Domains (3) summary

pfam13499
Location:96 – 148
Blast Score: 101

EF_hand_5; EF-hand domain pair

pfam13833
Location:30 – 87
Blast Score: 137

EF_hand_6; EF-hand domain pair

cl08302
Location:90 – 118
Blast Score: 84

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_003130.3 → NP_003121.1 sorcin isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).

Source sequence(s)

AK129770, AK295225, AL117616, DA268050, DB540255

Consensus CDS

CCDS5612.1

UniProtKB/Swiss-Prot

P30626

Related

ENSP00000265729, OTTHUMP00000161663, ENST00000265729, OTTHUMT00000253680

Conserved Domains (3) summary

cd00051
Location:75 – 130
Blast Score: 113

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:111 – 163
Blast Score: 101

EF_hand_5; EF-hand domain pair

pfam13833
Location:45 – 102
Blast Score: 135

EF_hand_6; EF-hand domain pair
NM_198901.1 → NP_944490.1 sorcin isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region and uses an alternate translational start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A.

Source sequence(s)

AL117616, AL576812, BM739144, BM793972

Consensus CDS

CCDS47638.1

UniProtKB/TrEMBL

A8MTH6

Related

ENSP00000378137, OTTHUMP00000225575, ENST00000394641, OTTHUMT00000376750

Conserved Domains (3) summary

cd00051
Location:60 – 115
Blast Score: 113

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:96 – 148
Blast Score: 102

EF_hand_5; EF-hand domain pair

pfam13833
Location:30 – 87
Blast Score: 136

EF_hand_6; EF-hand domain pair

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

87834432..87856308, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

82444285..82466161, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

87165789..87187665, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC003991.1	AAB96327.1
genomic	AC005075.2 (111177..118133)	None
genomic	CH236949.1 (9640024..9661900)	None
genomic	CH471091.2	EAW76909.1
		EAW76910.1
		EAW76911.1
mRNA	AK129770.1	None
mRNA	AK295225.1	BAG58218.1
mRNA	AK296601.1	BAG59214.1
mRNA	AK310366.1	None
mRNA	AL039198.1	None
mRNA	AL117616.1	None
mRNA	AL576812.3	None
mRNA	BC011025.1	AAH11025.1
mRNA	BI524104.1	None
mRNA	BI559592.1	None
mRNA	BI597920.1	None
mRNA	BM739144.1	None
mRNA	BM793972.1	None
mRNA	BU854353.1	None
mRNA	DA268050.1	None
mRNA	DB540255.1	None
mRNA	L12387.1	AAA92155.1
mRNA	M32886.1	AAA60588.1