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    SPP1 secreted phosphoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 6696, updated on 16-Jun-2013
    Official Symbol
    SPP1provided by HGNC
    Official Full Name
    secreted phosphoprotein 1provided by HGNC
    Primary source
    HGNC:11255
    Locus tag
    PSEC0156
    See related
    Ensembl:ENSG00000118785; HPRD:01325; MIM:166490; Vega:OTTHUMG00000130599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OPN; BNSP; BSPI; ETA-1
    Summary
    The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Location :
    4q22.1
    Sequence :
    Chromosome: 4; NC_000004.11 (88896802..88904563)
    See SPP1 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene Neighboring gene polycystic kidney disease 2 (autosomal dominant) Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 2 Neighboring gene ribosomal protein L31 pseudogene 24

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Hypoxia-related molecules HIF-1α, CA9, and osteopontin : predictors of survival in patients with high-grade glioma. Erpolat OP, et al. Strahlenther Onkol, 2013 Feb. PMID 23263636.
    2. Expression and clinical significance of osteopontin in calcified breast tissue. Huan JL, et al. Asian Pac J Cancer Prev, 2012. PMID 23244138.
    3. SPP1 gene polymorphisms associated with nephrolithiasis in Turkish pediatric patients. Tekin G, et al. Urol J, 2012 Fall. PMID 23235966.
    4. Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. Yamaguchi Y, et al. J Biol Chem, 2013 Feb 1. PMID 23204518.
    5. Osteopontin level in synovial fluid is associated with the severity of joint pain and cartilage degradation after anterior cruciate ligament rupture. Yamaga M, et al. PLoS One, 2012. PMID 23166604.

    See all (573) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. elevated OPN level in plasma and tumor tissues was significantly associated with metastasis and survival of laryngeal and hypopharyngeal carcinomas.
      Title: Elevated content of osteopontin in plasma and tumor tissues of patients with laryngeal and hypopharyngeal carcinoma associated with metastasis and prognosis.
    2. SPP1 polymorphisms were found to be associated with nephrolithiasis and it may be suggested that SPP1 gene polymorphism could be a useful marker for evaluation of the early genetic risk factor in childhood nephrolithiasis.
      Title: SPP1 gene polymorphisms associated with nephrolithiasis in Turkish pediatric patients.
    3. High osteopontin expression is associated with breast calcification leading to breast cancer.
      Title: Expression and clinical significance of osteopontin in calcified breast tissue.
    4. Hyaluronic acid can upregulate OPN mRNA expression in osteoarthritis fibroblast-like synoviocytes.
      Title: The effect of hyaluronic acid on osteopontin and CD44 mRNA of fibroblast-like synoviocytes in patients with osteoarthritis of the knee.
    5. Serum osteopontin refelects the severity of liver damage in hepatitis C virus infected subjects.
      Title: Elevated serum osteopontin levels in chronic hepatitis C virus infection: association with autoimmune rheumatologic manifestations.
    6. Data indicate that variation at nt -443 in the osteopontin (OPN) promoter increases the potential for gastric cancer metastasis and subsequent death in the Chinese population.
      Title: Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer.
    7. OPN and NF-kappaB P65 were involved in the pathogenesis of aortic aneurysms. OPN can up-regulate the expression of MMP and uPA via NF-kappaB signaling pathway.
      Title: The elevated expression of osteopontin and NF-κB in human aortic aneurysms and its implication.
    8. Only osteopontin gene +1239A > C SNP displayed a statistically significant association with MS development.
      Title: The impact of osteopontin gene variations on multiple sclerosis development and progression.
    9. Neither CD44H nor CD44v6 scores correlated with the osteopontin expression score or Ki-67 index. Osteopontin immunoexpression was highest in PCNSL, suggesting its probable role in its pathogenesis.
      Title: Preferential up-regulation of osteopontin in primary central nervous system lymphoma does not correlate with putative receptor CD44v6 or CD44H expression.
    10. Osteopontin level in synovial fluid is associated with the severity of joint pain and cartilage degradation after anterior cruciate ligament rupture.
      Title: Osteopontin level in synovial fluid is associated with the severity of joint pain and cartilage degradation after anterior cruciate ligament rupture.
    Submit: New GeneRIF Correction See all (494)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    P10451 Q9NUQ8 ABCF3    HPRD  PubMed  
    P10451 P13686 ACP5    HPRD  PubMed  
    P10451 P16070 CD44    HPRD  PubMed  
    P10451 P68400 CSNK2A1    HPRD  PubMed  
    P10451 P19784 CSNK2A2    HPRD  PubMed  
    P10451 Q8WYA6 CTNNBL1    HPRD  PubMed  
    P10451 P00734 F2    HPRD  PubMed  
    P10451 P24593 IGFBP5    HPRD  PubMed  
    P10451 P08648 ITGA5    HPRD  PubMed  
    P10451 Q13797 ITGA9    HPRD  PubMed  
    P10451 P06756 ITGAV    HPRD  PubMed  
    P10451 P05556 ITGB1    HPRD  PubMed  
    P10451 P08254 MMP3    HPRD  PubMed  
    P10451 P09237 MMP7    HPRD  PubMed  
    P10451 Q9NR12 PDLIM7    HPRD  PubMed  
    P10451 P17252 PRKCA    HPRD  PubMed  
    P10451 P14619 PRKG1    HPRD  PubMed  
    P10451 O43765 SGTA    HPRD  PubMed  
    P10451 Q9NRR5 UBQLN4    HPRD  PubMed  
    BioGRID:112574 BioGRID:118016 AFF4    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:119530 AMOTL2    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:106832 APOA1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:106978 ATP2A2    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:107000 ATP5F1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:113647 BAG6    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:113715 BRD3    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:119431 C1RL    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:126256 C2orf50    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:117994 CACNG4    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:107252 CALM1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:128291 CC2D1B    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:107530 CHD1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:138922 CISD2    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:125844 CMTM3    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:127317 COMMD1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:116183 COPS5    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:121123 CTNNBL1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:108071 CYB5R3    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:108008 DCX    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:109569 DNAJB1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:119052 DNTTIP2    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:124911 DSEL    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:108237 EEF1A1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:118148 EIF3K    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:108348 EPAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:108773 FTH1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:121210 GRIPAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:109290 HBA2    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:109393 HMGN1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:109709 IGFBP5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112574 BioGRID:109884 ITGA5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112574 BioGRID:119044 KCNIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:116506 KIAA1009    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:122061 LRRC4    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:110303 MAP1A    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:110304 MAP1B    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:110257 MARCKS    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:107213 MPPED1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112070 MRPL23    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:110748 NACA    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:116003 NCKAP1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:116961 NCSTN    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:114682 PDLIM7    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:115672 PEMT    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:111208 PEPD    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:117173 PLD3    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:111554 PRKACB    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:115359 RANBP9    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:115045 RAPGEF2    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:111865 RBBP6    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:126676 RIMS4    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112057 RPL13    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112058 RPL15    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112045 RPL5    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112121 RPS13    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:114991 SEC24C    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112347 SGTA    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:117332 SLC39A6    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:117101 SNAPIN    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112619 SSB    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:112657 STAU1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:118159 STK39    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:116311 TBC1D8    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:122167 TMEM168    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:120872 TMEM30A    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:113030 TPT1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:113116 TTC1    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:128444 TUBB    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:121223 UBQLN4    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:123904 USP42    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:114555 USP8    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:118145 ZNF638    BioGRID  PubMed Two-hybrid 
    BioGRID:112574 BioGRID:124875 ZNF804A    BioGRID  PubMed Two-hybrid 
    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
      Endochondral Ossification, organism-specific biosystem
      Endochondral Ossification
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • Osteoclast Signaling, organism-specific biosystem (from WikiPathways)
      Osteoclast Signaling, organism-specific biosystem
      Osteoclast Signaling
    • Osteopontin Signaling, organism-specific biosystem (from WikiPathways)
      Osteopontin Signaling, organism-specific biosystemStudy of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin (OPN) through IKK signaling pathway.
    • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
      Osteopontin-mediated events, organism-specific biosystem
      Osteopontin-mediated events
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC110940

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    decidualization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    embryo implantation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of collateral sprouting of intact axon in response to injury IEA
    Inferred from Electronic Annotation
    more info
    		  
    neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to steroid hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to vitamin D IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    osteopontin
    Names
    osteopontin
    uropontin
    nephropontin
    SPP1/CALPHA1 fusion
    urinary stone protein
    early T-lymphocyte activation 1
    osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
    secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030362.1 RefSeqGene

      Range
      5001..12762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000582.2 → NP_000573.1  osteopontin isoform OPN-b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (OPN-b, as described in PubMed: 7837791) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
      Source sequence(s)
      AF052124, BF699765, BX648003, CB117856
      Consensus CDS
      CCDS3626.1
      UniProtKB/Swiss-Prot
      P10451
      Related
      ENSP00000237623, OTTHUMP00000161174, ENST00000237623, OTTHUMT00000253049
      Conserved Domains (1) summary
      smart00017
      Location:17 – 300
      Blast Score: 684
      OSTEO; Osteopontin

    2. NM_001040058.1 → NP_001035147.1  osteopontin isoform OPN-a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (OPN-a, as described in PubMed: 7837791) has a shorter and distinct N-terminus compared to isoform e.
      Source sequence(s)
      AA665210, BC017387, CB117856
      Consensus CDS
      CCDS43250.1
      UniProtKB/Swiss-Prot
      P10451
      Related
      ENSP00000378517, OTTHUMP00000161173, ENST00000395080, OTTHUMT00000253048
      Conserved Domains (1) summary
      smart00017
      Location:17 – 314
      Blast Score: 751
      OSTEO; Osteopontin

    3. NM_001040060.1 → NP_001035149.1  osteopontin isoform OPN-c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (OPN-c, as described in PubMed: 7837791) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
      Source sequence(s)
      AA665210, AC131944, BC093033, DA419665
      Consensus CDS
      CCDS34027.1
      UniProtKB/Swiss-Prot
      P10451
      Conserved Domains (1) summary
      pfam00865
      Location:20 – 287
      Blast Score: 583
      Osteopontin; Osteopontin

    4. NM_001251829.1 → NP_001238758.1  osteopontin isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 5. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform e.
      Source sequence(s)
      AB209987, AC131944, CB117856, JF412667
      UniProtKB/Swiss-Prot
      P10451
      UniProtKB/TrEMBL
      Q3LGB0
      Conserved Domains (1) summary
      pfam00865
      Location:91 – 273
      Blast Score: 573
      Osteopontin; Osteopontin

    5. NM_001251830.1 → NP_001238759.1  osteopontin isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC131944, AK295491, CB117856, JF412667
      UniProtKB/TrEMBL
      B7Z351
      UniProtKB/Swiss-Prot
      P10451
      Conserved Domains (1) summary
      pfam00865
      Location:43 – 327
      Blast Score: 707
      Osteopontin; Osteopontin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p10 Primary Assembly

      Range
      88896802..88904563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      84643231..84650994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018915.1 Alternate CHM1_1.0

      Range
      88705381..88713139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01063542.1 (25148..32911) None
    genomic AC131944.1 AAY41035.1
    genomic AMYH01014382.1 (38098..45856) None
    genomic CH471057.1 EAX06004.1
      EAX06005.1
      EAX06006.1
      EAX06007.1
      EAX06008.1
      EAX06009.1
      EAX06010.1
    genomic D14813.1 BAA03554.1
    genomic GN077143.1 CAX69239.1
    genomic HI519544.1 CBX54353.1
    genomic U20758.1 AAA86886.1
    mRNA AA665210.1 None
    mRNA AB209987.1 BAE45628.1
    mRNA AB469789.1 BAH58215.1
    mRNA AF052124.1 AAC28619.1
    mRNA AK057738.1 None
    mRNA AK075463.1 BAC11635.1
    mRNA AK290090.1 BAF82779.1
    mRNA AK290104.1 BAF82793.1
    mRNA AK295491.1 BAH12087.1
    mRNA AK296035.1 BAG58801.1
    mRNA AK315461.1 BAG37848.1
    mRNA AY956318.1 AAX59003.1
    mRNA BC007016.1 AAH07016.1
    mRNA BC017387.1 AAH17387.1
    mRNA BC022844.1 AAH22844.1
    mRNA BC093033.1 AAH93033.1
    mRNA BF699765.1 None
    mRNA BX648003.1 None
    mRNA CB117856.1 None
    mRNA D28759.1 BAA05949.1
    mRNA D28760.1 BAA05950.1
    mRNA D28761.1 BAA05951.1
    mRNA DA419665.1 None
    mRNA DQ839491.1 ABI63352.1
    mRNA DQ846870.1 ABI63357.1
    mRNA DQ846871.1 ABI63358.1
    mRNA HQ874460.1 AEA49027.1
    mRNA HQ874461.1 AEA49028.1
    mRNA J04765.1 AAA59974.1
    mRNA JF412666.1 AEA49030.1
    mRNA JF412667.1 AEA49031.1
    mRNA M83248.1 AAA17675.1
    mRNA X13694.1 CAA31984.1
    other-genetic AM392768.1 CAL37646.1
    other-genetic AM392898.1 CAL37776.1
    other-genetic DQ892544.2 ABM83470.1
    other-genetic DQ895755.2 ABM86681.1
    other-genetic EU831940.1 ACE87381.1
    other-genetic EU832035.1 ACE86697.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10451.1 GenPept UniProtKB/Swiss-Prot:P10451

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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