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SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 [ Homo sapiens (human) ]

Gene ID: 6695, updated on 8-May-2016
Official Symbol
SPOCK1provided by HGNC
Official Full Name
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1provided by HGNC
Primary source
HGNC:HGNC:11251
See related
Ensembl:ENSG00000152377 HPRD:11887; MIM:602264; Vega:OTTHUMG00000129157
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIC1; SPOCK; TESTICAN
Summary
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q31.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (136975298..137499329, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (136310987..136835018, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 49 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 193 Neighboring gene uncharacterized LOC105379192 Neighboring gene kelch like family member 3 Neighboring gene microRNA 874 Neighboring gene heterogeneous nuclear ribonucleoprotein A0

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
NHGRI GWA Catalog
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
central nervous system neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell-substrate adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
node of Ranvier ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density NAS
Non-traceable Author Statement
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
sarcoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034127.1 RefSeqGene

    Range
    5001..529032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004598.3NP_004589.1  testican-1 precursor

    See identical proteins and their annotated locations for NP_004589.1

    Status: REVIEWED

    Source sequence(s)
    AC005213, AF231124, BC030691, BI550122
    Consensus CDS
    CCDS4191.1
    UniProtKB/Swiss-Prot
    Q08629
    Related
    ENSP00000378401, OTTHUMP00000159433, ENST00000394945, OTTHUMT00000251222
    Conserved Domains (3) summary
    cd00104
    Location:139178
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00191
    Location:312372
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:197315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    136975298..137499329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    135743638..136267703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)