Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Sdhaprovided by MGI
Official Full Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by MGI
Primary source: MGI:1914195
See related: Ensembl:ENSMUSG00000021577; Vega:OTTMUSG00000030724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FP; SDH2; SDHF; C81073; 4921513A11; 1500032O14Rik; 2310034D06Rik

Genomic context

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Location :: 13 C1; 13

Sequence :: Chromosome: 13; NC_000079.6 (74322255..74350240, complement)

See Sdha in Epigenomics, MapViewer

Chromosome 13 - NC_000079.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
Title: Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Data show that SdhA is required for preventing AIM2 inflammasome activation.
Title: Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.
Data show that two subunits of complex II (succinate dehydrogenase, or SDH), SDHA and SDHB, interacted specifically with SIRT3.
Title: Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.
Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes.
Title: [Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes].

Submit: New GeneRIF Correction

Pathways from BioSystems

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Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Amino Acid metabolism, organism-specific biosystem (from WikiPathways)
Amino Acid metabolism, organism-specific biosystemA complete overview of the metabolism of all 20 amino acids
Citrate cycle (TCA cycle), organism-specific biosystem (from KEGG)
Citrate cycle (TCA cycle), organism-specific biosystemThe citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form ...
Citrate cycle (TCA cycle), conserved biosystem (from KEGG)
Citrate cycle (TCA cycle), conserved biosystemThe citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form ...
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, organism-specific biosystem (from KEGG)
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, conserved biosystem (from KEGG)
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Citric acid cycle (TCA cycle), organism-specific biosystem (from REACTOME)
Citric acid cycle (TCA cycle), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Electron Transport Chain, organism-specific biosystem (from WikiPathways)
Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Oxidative phosphorylation, organism-specific biosystem (from KEGG)
Oxidative phosphorylation, organism-specific biosystem
Oxidative phosphorylation
Oxidative phosphorylation, conserved biosystem (from KEGG)
Oxidative phosphorylation, conserved biosystem
Oxidative phosphorylation
Parkinson's disease, organism-specific biosystem (from KEGG)
Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL...
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Respiratory electron transport, organism-specific biosystem (from REACTOME)
Respiratory electron transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem (from REACTOME)
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystemcomputationally inferred pathway (not manually curated)
Succinate dehydrogenase (ubiquinone), organism-specific biosystem (from KEGG)
Succinate dehydrogenase (ubiquinone), organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
TCA Cycle, organism-specific biosystem (from WikiPathways)
TCA Cycle, organism-specific biosystemThe [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-cata...
TCA cycle, organism-specific biosystem (from BIOCYC)
TCA cycle, organism-specific biosystem
TCA cycle
TCA cycle variation III (eukaryotic), organism-specific biosystem (from BIOCYC)
TCA cycle variation III (eukaryotic), organism-specific biosystem
TCA cycle variation III (eukaryotic)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
aerobic respiration -- electron donor II, organism-specific biosystem (from BIOCYC)
aerobic respiration -- electron donor II, organism-specific biosystem
aerobic respiration -- electron donor II
aerobic respiration -- electron donors reaction list, organism-specific biosystem (from BIOCYC)
aerobic respiration -- electron donors reaction list, organism-specific biosystem
aerobic respiration -- electron donors reaction list

General gene information

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Markers

Sdha (e-PCR), detects polymorphism
- UniSTS:507208

D17986 (e-PCR)
- UniSTS:124757

RH127008 (e-PCR)
- UniSTS:209773

NoName (e-PCR)
- UniSTS:237052

Homology

Homologs of the Sdha gene: The Sdha gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
succinate dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
electron transport chain	IEA Inferred from Electronic Annotation more info
nervous system development	ISO Inferred from Sequence Orthology more info
oxidation-reduction process	ISO Inferred from Sequence Orthology more info
respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
succinate metabolic process	ISO Inferred from Sequence Orthology more info
transport	IEA Inferred from Electronic Annotation more info
tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Names: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; flavoprotein subunit of complex II

NP_075770.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023281.1 → NP_075770.1 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AK010561, AK034928

Consensus CDS

CCDS26643.1

UniProtKB/Swiss-Prot

Q8K2B3

Related

ENSMUSP00000022062, OTTMUSP00000039973, ENSMUST00000022062, OTTMUST00000076054

Conserved Domains (3) summary

PTZ00139
Location:35 – 664
Blast Score: 2878

PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional

pfam02910
Location:512 – 664
Blast Score: 442

Succ_DH_flav_C; Fumarate reductase flavoprotein C-term

cl09931
Location:85 – 471
Blast Score: 602

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000079.6 Reference GRCm38.p1 C57BL/6J

Range

74322255..74350240, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000035.1 Alternate Mm_Celera

Range

76651719..76679576, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01107676.1 (96037..107454)	None
genomic	AAHY01107677.1	None
genomic	CH466563.1	EDL37092.1	mixed
genomic	CT009486.7 (87566..115551)	None
mRNA	AF095938.1	AAC72373.1
mRNA	AK004362.1	BAE43173.1	C57BL/6J
mRNA	AK005350.1	None	C57BL/6J
mRNA	AK010561.1	None	C57BL/6J
mRNA	AK029520.1	BAC26491.1	C57BL/6J
mRNA	AK034928.1	BAC28884.1	C57BL/6J
mRNA	AK049590.1	BAC33831.1	C57BL/6J
mRNA	AK050475.1	BAC34276.1	C57BL/6J
mRNA	AK075990.1	BAC36101.1	C57BL/6J
mRNA	AK145923.1	BAE26754.1
mRNA	AK147286.1	BAE27822.1	C57BL/6J
mRNA	AK147624.1	BAE28032.1	C57BL/6J
mRNA	AK151333.1	None	C57BL/6J
mRNA	AK153085.1	BAE31710.1	C57BL/6J
mRNA	AK162148.1	BAE36754.1	C57BL/6J
mRNA	AK169254.1	BAE41018.1	C57BL/6J
mRNA	AK181772.1	None
mRNA	AK188951.1	None
mRNA	AK189959.1	None
mRNA	AK190473.1	None
mRNA	AK192579.1	None
mRNA	AK196808.1	None
mRNA	AK202068.1	None
mRNA	AK202419.1	None
mRNA	AK207174.1	None
mRNA	AK207777.1	None
mRNA	AK207923.1	None
mRNA	AK208186.1	None
mRNA	AK209906.1	None
mRNA	AK214298.1	None
mRNA	AK214998.1	None
mRNA	AK215517.1	None
mRNA	AK215982.1	None
mRNA	AK216171.1	None
mRNA	AK216523.1	None
mRNA	AK217885.1	None
mRNA	AK217952.1	None
mRNA	AY618570.1	AAT40731.1	SJL/JHanHsd
mRNA	BC011301.1	AAH11301.1	FVB/N
mRNA	BC031849.1	AAH31849.1	CZECHII
mRNA	DQ402975.1	ABD77308.1