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    Shisa5 shisa homolog 5 (Xenopus laevis) [ Mus musculus (house mouse) ]

    Gene ID: 66940, updated on 26-Feb-2013
    Official Symbol
    Shisa5provided by MGI
    Official Full Name
    shisa homolog 5 (Xenopus laevis)provided by MGI
    Primary source
    MGI:1915044
    See related
    Ensembl:ENSMUSG00000025647; Vega:OTTMUSG00000031613
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scotin; mShisa5; 2310008D10Rik; 6430628I05Rik
    Location :
    9 F2; 9
    Sequence :
    Chromosome: 9; NC_000075.6 (109038627..109057766)
    See Shisa5 in Epigenomics, MapViewer

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene urocortin 2 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.
    3. Cell cycle regulation by the pro-apoptotic gene Scotin. Gupta RK, et al. Cell Cycle, 2008 Aug. PMID 18677103.
    4. Scotin: A new p63 target gene expressed during epidermal differentiation. Zocchi L, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18164684.
    5. The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. Draeby I, et al. Arch Biochem Biophys, 2007 Nov 1. PMID 17889823.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Mouse Scotin induces apoptosis and developmental defects when overexpressed in Drosophila.
      Title: Cell cycle regulation by the pro-apoptotic gene Scotin.
    2. We conclude that Scotin is a new p63 target gene induced during epithelial differentiation, a complex process that also involves ER stress induction.
      Title: Scotin: A new p63 target gene expressed during epidermal differentiation.
    3. ALG-2 binding to Scotin is strictly calcium dependent, indicating a role of this interaction in calcium signaling pathways
      Title: The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.
    4. Scotin plays a role in p53-dependent apoptosis
      Title: Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    signal transducer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    protein shisa-5
    Names
    protein shisa-5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025858.2 → NP_080134.1  protein shisa-5 isoform 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS23543.1
      UniProtKB/Swiss-Prot
      Q9D7I0
      Related
      ENSMUSP00000026737, OTTMUSP00000041629, ENSMUST00000026737, OTTMUST00000078308
      Conserved Domains (1) summary
      pfam13908
      Location:24 – 144
      Blast Score: 135
      Shisa; Wnt and FGF inhibitory regulator

    2. NM_026381.4 → NP_080657.1  protein shisa-5 isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      AC140383
      Consensus CDS
      CCDS40771.1
      UniProtKB/Swiss-Prot
      Q9D7I0

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p1 C57BL/6J

      Range
      109038627..109057766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      108597405..108616548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01081587.1 (17951..37094) None
    genomic AC140383.2 (72384..91523) None
    genomic AC174646.2 (59997..79137) None
    genomic CH466560.1 EDL21329.1 mixed
      EDL21330.1 mixed
      EDL21331.1 mixed
      EDL21332.1 mixed
      EDL21333.1 mixed
      EDL21334.1 mixed
      EDL21335.1 mixed
      EDL21336.1 mixed
      EDL21337.1 mixed
    mRNA AF520699.1 AAM74233.1 129/Sv
    mRNA AK009225.1 BAB26148.1 C57BL/6J
    mRNA AK018291.1 BAB31149.1 C57BL/6J
    mRNA AK020877.1 BAB32237.1 C57BL/6J
    mRNA AK033545.1 BAC28350.1 C57BL/6J
    mRNA AK045368.1 BAC32331.1 C57BL/6J
    mRNA AK081060.1 BAC38125.1 C57BL/6J
    mRNA AK088188.1 BAC40197.1 NOD
    mRNA AK090357.1 BAC41183.1 C57BL/6J
    mRNA AK090373.1 BAC41188.1 C57BL/6J
    mRNA AK150460.1 None C57BL/6J
    mRNA AK151632.1 None C57BL/6J
    mRNA AK178622.1 None
    mRNA AK182311.1 None
    mRNA AK183004.1 None
    mRNA AK184395.1 None
    mRNA AK205406.1 None
    mRNA AK207879.1 None
    mRNA AK212074.1 None
    mRNA AK219265.1 None
    mRNA BC010238.1 AAH10238.1 FVB/N
    mRNA BC017600.1 AAH17600.1 FVB/N
    mRNA BC057089.1 AAH57089.1 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7I0.1 GenPept UniProtKB/Swiss-Prot:Q9D7I0

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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