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Bzw2 basic leucine zipper and W2 domains 2 [ Mus musculus (house mouse) ]

Gene ID: 66912, updated on 21-Apr-2024

Summary

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Official Symbol
Bzw2provided by MGI
Official Full Name
basic leucine zipper and W2 domains 2provided by MGI
Primary source
MGI:MGI:1914162
See related
Ensembl:ENSMUSG00000020547 AllianceGenome:MGI:1914162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5mp1; Bdm2; HSPC028; 1110001I24Rik
Summary
Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; cardiovascular system; and genitourinary system. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 47.3), CNS E14 (RPKM 41.6) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A3; 12 16.42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (36141834..36206922, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (36091835..36156841, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10744 Neighboring gene STARR-positive B cell enhancer ABC_E2382 Neighboring gene STARR-seq mESC enhancer starr_31914 Neighboring gene ubiquitin-conjugating enzyme E2F (putative), retrotransposed Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_31915 Neighboring gene STARR-positive B cell enhancer ABC_E1153 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene leucine rich repeat containing 72 Neighboring gene STARR-seq mESC enhancer starr_31916 Neighboring gene predicted gene, 40390

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Zhang J, et al. Nat Commun, 2022 Nov 4. PMID 36333315, Free PMC Article
  2. Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration. Shen ZJ, et al. Cells, 2021 Jan 21. PMID 33494375, Free PMC Article
  3. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
  4. Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Tachikawa K, et al. Neurosci Res, 2008 Feb. PMID 18055048
  5. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Yu C, et al. Cell Res, 2016 Mar. PMID 26902285, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
    Title: BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.
  2. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
    Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7203

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eIF5-mimic protein 1
Names
basic leucine zipper and W2 domain-containing protein 2
brain development-related molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025840.3 → NP_080116.2  eIF5-mimic protein 1

    See identical proteins and their annotated locations for NP_080116.2

    Status: VALIDATED

    Source sequence(s)
    AK160544, BQ032572, BY009345
    Consensus CDS
    CCDS25884.1
    UniProtKB/Swiss-Prot
    Q2L4X1, Q91VK1, Q9D0N4
    UniProtKB/TrEMBL
    Q3V199
    Related
    ENSMUSP00000020856.5, ENSMUST00000020856.6
    Conserved Domains (1) summary
    cd11560
    Location:218 → 408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    36141834..36206922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515166.4 → XP_006515229.1  eIF5-mimic protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3V199
    Related
    ENSMUST00000221521.2
    Conserved Domains (1) summary
    cl17013
    Location:218 → 369
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2L4X1.1 GenPept UniProtKB/Swiss-Prot:Q2L4X1
Q91VK1.1 GenPept UniProtKB/Swiss-Prot:Q91VK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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