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Wwp2 WW domain containing E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 66894, updated on 8-May-2016
Official Symbol
Wwp2provided by MGI
Official Full Name
WW domain containing E3 ubiquitin protein ligase 2provided by MGI
Primary source
MGI:MGI:1914144
See related
Ensembl:ENSMUSG00000031930
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIP2; AA690238; AW554328; 1300010O06Rik
Orthologs
Location:
8; 8 D3
Exon count:
26
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (107436368..107558597)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (109960298..110082495)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene NIN1/RPN12 binding protein 1 homolog Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene predicted gene, 39241 Neighboring gene microRNA 140 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Neighboring gene 60S ribosomal protein L29 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II transcription factor binding IGI
Inferred from Genetic Interaction
more info
PubMed 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP2
Names
WW domain-containing protein 2
WW domain-containing protein 4
NP_080106.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025830.3NP_080106.1  NEDD4-like E3 ubiquitin-protein ligase WWP2

    See identical proteins and their annotated locations for NP_080106.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048184
    Consensus CDS
    CCDS40467.1
    UniProtKB/Swiss-Prot
    Q9DBH0
    UniProtKB/TrEMBL
    I3RSH5
    Related
    ENSMUSP00000132224, ENSMUST00000166615
    Conserved Domains (4) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:539867
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:408436
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    107436368..107558597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531299.2XP_006531362.1  

    See identical proteins and their annotated locations for XP_006531362.1

    UniProtKB/Swiss-Prot
    Q9DBH0
    UniProtKB/TrEMBL
    I3RSH5
    Conserved Domains (4) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:539867
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:516868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:408436
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  2. XM_011248488.1XP_011246790.1  

    Conserved Domains (2) summary
    cd04021
    Location:17142
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00201
    Location:408436
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  3. XM_006531301.1XP_006531364.1  

    See identical proteins and their annotated locations for XP_006531364.1

    UniProtKB/TrEMBL
    Q3TXI7
    Conserved Domains (3) summary
    smart00119
    Location:100428
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:77429
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:838
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    111667038..111789943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)