Ccnh cyclin H [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Ccnhprovided by MGI
Official Full Name: cyclin Hprovided by MGI
Primary source: MGI:1913921
See related: Ensembl:ENSMUSG00000021548; Vega:OTTMUSG00000035504
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI661354; AV102684; AW538719; 6330408H09Rik

Genomic context

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Location :: 13 C3; 13

Sequence :: Chromosome: 13; NC_000079.6 (85189477..85213723)

See Ccnh in Epigenomics, MapViewer

Chromosome 13 - NC_000079.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis.
Title: Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:211635	BioGRID:207616	Atf7ip	BioGRID	PubMed	Affinity Capture-Western
BioGRID:211635	BioGRID:198650	Cdk7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:211635	BioGRID:202515	Pura	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
Cell cycle signaling pathway, organism-specific biosystem
Cell cycle signaling pathway
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in GG-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in TC-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
Formation of RNA Pol II elongation complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of incision complex in GG-NER, organism-specific biosystem (from REACTOME)
Formation of incision complex in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
Formation of the Early Elongation Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem (from REACTOME)
Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 Phase, organism-specific biosystem (from REACTOME)
G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genomic NER (GG-NER), organism-specific biosystem (from REACTOME)
Global Genomic NER (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Holo-TFIIH complex, organism-specific biosystem (from KEGG)
Holo-TFIIH complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Chain Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase I Chain Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase I Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase I Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I Transcription Termination, organism-specific biosystem (from REACTOME)
RNA Polymerase I Transcription Termination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcription-coupled NER (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-coupled NER (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
estrogen signalling, organism-specific biosystem (from WikiPathways)
estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
mRNA Capping, organism-specific biosystem (from REACTOME)
mRNA Capping, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

AW538719 (e-PCR)
- UniSTS:180514

AV102684 (e-PCR)
- UniSTS:164532

Ccnh (e-PCR), detects polymorphism
- UniSTS:531444

AI661354 (e-PCR)
- UniSTS:165884

Homology

Homologs of the Ccnh gene: The Ccnh gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
protein phosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of cell cycle	IEA Inferred from Electronic Annotation more info
regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
DNA-directed RNA polymerase II, holoenzyme	IEA Inferred from Electronic Annotation more info
cyclin-dependent protein kinase activating kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
holo TFIIH complex	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-H

Names: cyclin-H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023243.5 → NP_075732.1 cyclin-H

Status: PROVISIONAL

Source sequence(s)

AC154271

Consensus CDS

CCDS26666.1

UniProtKB/Swiss-Prot

Q61458

Related

ENSMUSP00000022030, OTTMUSP00000050004, ENSMUST00000022030, OTTMUST00000090919

Conserved Domains (2) summary

cd00043
Location:64 – 126
Blast Score: 117

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

TIGR00569
Location:2 – 308
Blast Score: 1157

ccl1; cyclin ccl1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000079.6 Reference GRCm38.p1 C57BL/6J

Range

85189477..85213723

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000035.1 Alternate Mm_Celera

Range

87421607..87445967

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01108316.1 (9548..33908)	None
genomic	AC154271.2 (1704..25951)	None
genomic	CH466563.1	EDL37164.1	mixed
		EDL37165.1	mixed
mRNA	AF287135.1	AAF90198.1
mRNA	AK007910.1	BAB25343.1	C57BL/6J
mRNA	AK020801.1	None	C57BL/6J
mRNA	AK078059.1	BAC37112.1	C57BL/6J
mRNA	AK137849.1	BAE23508.1	C57BL/6J
mRNA	AK185780.1	None
mRNA	AK215242.1	None
mRNA	AK217691.1	None
mRNA	BC038861.1	AAH38861.1	C57BL/6J
mRNA	X82441.1	CAA57822.1	CD-1