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SOX15 SRY-box 15 [ Homo sapiens (human) ]

Gene ID: 6665, updated on 8-May-2016
Official Symbol
SOX15provided by HGNC
Official Full Name
SRY-box 15provided by HGNC
Primary source
HGNC:HGNC:11196
See related
Ensembl:ENSG00000129194 HPRD:03191; MIM:601297; Vega:OTTHUMG00000178146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOX20; SOX26; SOX27
Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17p13.1
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (7588180..7590170, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7491496..7494037, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996842 Neighboring gene uncharacterized LOC100996842 Neighboring gene CD68 molecule Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene FMR1 autosomal homolog 2 Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2

NHGRI GWAS Catalog

Description
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
male gonad development TAS
Traceable Author Statement
more info
PubMed 
myoblast development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of G0 to G1 transition ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of myoblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of satellite cell activation involved in skeletal muscle regeneration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
skeletal muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
protein SOX-15
Names
SRY (sex determining region Y)-box 15
SRY (sex determining region Y)-box 20
SRY box 15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006942.1NP_008873.1  protein SOX-15

    See identical proteins and their annotated locations for NP_008873.1

    Status: REVIEWED

    Source sequence(s)
    AB006867
    Consensus CDS
    CCDS32549.1
    UniProtKB/Swiss-Prot
    O60248
    Related
    ENSP00000355354, OTTHUMP00000258639, ENST00000250055, OTTHUMT00000440757
    Conserved Domains (1) summary
    cd01388
    Location:48119
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    7588180..7590170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    7500429..7502419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)