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    Mcm8 minichromosome maintenance deficient 8 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 66634, updated on 26-Feb-2013
    Official Symbol
    Mcm8provided by MGI
    Official Full Name
    minichromosome maintenance deficient 8 (S. cerevisiae)provided by MGI
    Primary source
    MGI:1913884
    Locus tag
    RP23-77H16.3
    See related
    Ensembl:ENSMUSG00000027353; Vega:OTTMUSG00000015646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730432L01Rik
    Location :
    2; 2 F3
    Sequence :
    Chromosome: 2; NC_000068.7 (132816335..132844197)
    See Mcm8 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene chromogranin B Neighboring gene tRNA methyltransferase 6 Neighboring gene cardiolipin synthase 1 Neighboring gene leucine rich repeat neuronal 4

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Lutzmann M, et al. Mol Cell, 2012 Aug 24. PMID 22771120.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073.
    5. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MCM8 and MCM9 form a complex and that they coregulate their stability.
      Title: MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    molecular_function ND
    No biological Data available
    more info
    		  
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		  
    female gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    male gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		  
    response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    MCM8-MCM9 complex IDA
    Inferred from Direct Assay
    more info
    		  
    MCM8-MCM9 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    DNA helicase MCM8
    Names
    DNA helicase MCM8
    minichromosome maintenance 8
    DNA replication licensing factor MCM8
    NP_079952.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025676.3 → NP_079952.2  DNA helicase MCM8

      Status: PROVISIONAL

      Source sequence(s)
      AL929562
      Consensus CDS
      CCDS16778.1
      UniProtKB/Swiss-Prot
      Q9CWV1
      Related
      ENSMUSP00000066842, OTTMUSP00000016664, ENSMUST00000066559, OTTMUST00000037177
      Conserved Domains (2) summary
      cd00009
      Location:400 – 558
      Blast Score: 110
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00350
      Location:172 – 680
      Blast Score: 1083
      MCM; minichromosome maintenance proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p1 C57BL/6J

      Range
      132816335..132844197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      134043779..134071682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01020856.1 (35384..49146) None
    genomic AAHY01020857.1 (23052..37172) None
    genomic AL929562.12 (46337..74200) None
    genomic CH466519.1 EDL28361.1 mixed
      EDL28362.1 mixed
    genomic CS402805.1 CAL40374.1
    genomic CS402807.1 CAL40375.1
    mRNA AK010365.1 BAB26885.1 C57BL/6J
    mRNA AK012845.1 BAB28507.1 C57BL/6J
    mRNA AK017607.1 None C57BL/6J
    mRNA AK019268.1 BAB31638.1 C57BL/6J
    mRNA AK133858.1 BAE21892.1 C57BL/6J
    mRNA BC046780.1 AAH46780.1 C57BL/6
    mRNA BC052070.1 AAH52070.1 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWV1.3 GenPept UniProtKB/Swiss-Prot:Q9CWV1

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).

      Links to other resources

      General information

      Related sites

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