Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Spcs2provided by MGI
Official Full Name: signal peptidase complex subunit 2 homolog (S. cerevisiae)provided by MGI
Primary source: MGI:1913874
See related: Ensembl:ENSMUSG00000035227
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AA408713; mKIAA0102; 5730406I15Rik

Genomic context

Go to the top of the page Help

Location :: 7 E2; 7

Sequence :: Chromosome: 7; NC_000073.6 (99837569..99858883, complement)

See Spcs2 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from BioSystems

Go to the top of the page Help

Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem (from REACTOME)
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein export, organism-specific biosystem (from KEGG)
Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
Protein export, conserved biosystem (from KEGG)
Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Translation, organism-specific biosystem (from REACTOME)
Translation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Homology

Homologs of the Spcs2 gene: The Spcs2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
hydrolase activity	IEA Inferred from Electronic Annotation more info
molecular_function	ND No biological Data available more info
peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info
proteolysis	IEA Inferred from Electronic Annotation more info
signal peptide processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
signal peptidase complex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: signal peptidase complex subunit 2

Names: signal peptidase complex subunit 2; SPase 25 kDa subunit; microsomal signal peptidase 25 kDa subunit

NP_079944.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025668.3 → NP_079944.1 signal peptidase complex subunit 2

Status: PROVISIONAL

Source sequence(s)

AK134578

Consensus CDS

CCDS40033.1

UniProtKB/Swiss-Prot

Q9CYN2

Related

ENSMUSP00000041152, ENSMUST00000036274

Conserved Domains (1) summary

pfam06703
Location:55 – 219
Blast Score: 506

SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

99837569..99858883, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

100162809..100184293, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01064768.1 (13008..34492)	None
genomic	AC113298.14 (163565..170135)	None
genomic	AC115040.7 (158709..172117)	None
genomic	CH466531.1	EDL16412.1	mixed
mRNA	AK014310.1	BAB29262.1	C57BL/6J
mRNA	AK017504.1	BAB30777.1	C57BL/6J
mRNA	AK077510.1	BAC36836.1	C57BL/6J
mRNA	AK134578.1	BAE22190.1	C57BL/6J
mRNA	AK168173.1	BAE40134.1	DBA/2
mRNA	AK180141.1	None
mRNA	AK183363.1	None
mRNA	AK188156.1	None
mRNA	AK211106.1	None
mRNA	AK212862.1	None
mRNA	BC010547.1	AAH10547.2	FVB/N
mRNA	BC050150.1	AAH50150.1	C57BL/6J