BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like [Homo sapiens] - Gene

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Summary

Official Symbol: BNIP3Lprovided by HGNC
Official Full Name: BCL2/adenovirus E1B 19kDa interacting protein 3-likeprovided by HGNC
Primary source: HGNC:1085
See related: Ensembl:ENSG00000104765; HPRD:07288; MIM:605368; Vega:OTTHUMG00000099433
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NIX; BNIP3a
Summary: This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]

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Genomic context

Location :: 8p21

Sequence :: Chromosome: 8; NC_000008.10 (26240523..26270644)

See BNIP3L in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mitochondrial ROS and NIX are essential factors for Mieap-induced accumulation of lysosome-like organelles within mitochondria
Title: Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Nix functions as an autophagy receptor, which mediates mitochondrial clearance after mitochondrial damage and during erythrocyte differentiation
Title: Nix is a selective autophagy receptor for mitochondrial clearance.
Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.
Results suggest that hypoxia-induced autophagy via BNIP3 and BNIP3L is clearly a survival mechanism that promotes tumor progression.
Title: Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
Results report that oxygen deprivation can activate the autophagic pathway in human cancer cell lines via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.
Title: Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.
Homozygous deletions in a number of biologically important genes were found in prostate cancer cell lines, including PPP2R2A and BNIP3L identified in this study.
Title: Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
NIX is required for the selective elimination of mitochondria, however, because mitochondrial clearance, in the absence of NIX, is arrested at the stage of mitochondrial incorporation into autophagosomes and autophagosome maturation.
Title: NIX is required for programmed mitochondrial clearance during reticulocyte maturation.
The proapoptotic factor Nix is a highly regulated effector of growth during terminal erythroid maturation.
Title: The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.
NIX binds to TSAP6 in tumor cells and has a role in apoptosis
Title: The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NT_023666.17	NP_004371.1	CREBBP	BIND	PubMed	CBP interacts with Bnip3L.
NT_023666.17	NP_000537.2	TP53	BIND	PubMed	p53 interacts with Bnip3L.
O60238	P10415	BCL2	HPRD	PubMed
O60238	Q07817	BCL2L1	HPRD	PubMed
O60238	Q12983	BNIP3	HPRD	PubMed
O60238	O60238	BNIP3L	HPRD	PubMed
O60238	Q9P104	DOK5	HPRD	PubMed
O60238	Q01844	EWSR1	HPRD	PubMed
O60238	Q6NUQ1	RINT1	HPRD	PubMed
O60238	Dudulin 2	STEAP3	HPRD	PubMed
O60238	P17152	TMEM11	HPRD	PubMed
BioGRID:107133	BioGRID:107068	BCL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107133	BioGRID:107132	BNIP3	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:107133	BNIP3L	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:120926	DOK5	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:108431	EWSR1	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:108904	GBP2	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:115920	GNB5	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:127354	KLHL23	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:112019	ROBO2	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:120533	STEAP3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107133	BioGRID:114361	TMEM11	BioGRID	PubMed	Two-hybrid
BioGRID:107133	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
lamin binding	IDA Inferred from Direct Assay more info	PubMed
lamin binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
defense response to virus	IDA Inferred from Direct Assay more info	PubMed
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
mitochondrial protein catabolic process	IMP Inferred from Mutant Phenotype more info
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of survival gene product expression	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
intrinsic to membrane	TAS Traceable Author Statement more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial envelope	IEA Inferred from Electronic Annotation more info
mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004331.2 → NP_004322.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Status: REVIEWED

Source sequence(s)

AA946755, AB004788, AF536326, AL132665, BF337139, BQ719112, CD244492, CD558918

Consensus CDS

CCDS6050.1

UniProtKB/Swiss-Prot

O60238

UniProtKB/TrEMBL

Q6IBV1

Related

ENSP00000370003, OTTHUMP00000125280, ENST00000380629, OTTHUMT00000216895

Conserved Domains (1) summary

pfam06553
Location:31 – 219
Blast Score: 479

BNIP3; BNIP3

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

26240523..26270644

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

24785443..24815530

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011726.11 (109120..120103)	None
genomic	AC022911.6	None
genomic	AF255051.1	AAF70290.1
genomic	CH471080.2	EAW63576.1
mRNA	AA946755.1	None
mRNA	AB004788.1	BAA28692.1
mRNA	AF060922.1	AAG43134.1
mRNA	AF067396.1	AAD03589.1
mRNA	AF079221.1	AAC27723.1
mRNA	AF452712.2	AAL50978.1
mRNA	AF536326.1	AAN04051.1
mRNA	AK290213.1	BAF82902.1
mRNA	AK300286.1	BAG62043.1
mRNA	AK300727.1	BAG62400.1
mRNA	AK307195.1	None
mRNA	AK315870.1	BAF98761.1
mRNA	AK316315.1	BAH14686.1
mRNA	AL132665.1	CAI46217.1
mRNA	BC001559.1	AAH01559.1
mRNA	BC009603.1	AAH09603.1
mRNA	BF337139.1	None
mRNA	BQ719112.1	None
mRNA	BT019500.1	AAV38307.1
mRNA	BT019501.1	AAV38308.1
mRNA	CD244492.1	None
mRNA	CD558918.1	None
mRNA	CR456701.1	CAG32982.1
other-genetic	EU831983.1	ACE87424.1
other-genetic	EU832076.1	ACE86738.1
other-genetic	JF432628.1	ADZ15845.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O60238.1	GenPept	UniProtKB/Swiss-Prot:O60238
Q6IBV1	GenPept	UniProtKB/TrEMBL:Q6IBV1
Q9H3K3	GenPept	UniProtKB/TrEMBL:Q9H3K3