SOD3 superoxide dismutase 3, extracellular [Homo sapiens] - Gene

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Summary

Official Symbol: SOD3provided by HGNC
Official Full Name: superoxide dismutase 3, extracellularprovided by HGNC
Primary source: HGNC:11181
See related: Ensembl:ENSG00000109610; HPRD:01708; MIM:185490; Vega:OTTHUMG00000128565
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EC-SOD; MGC20077
Summary: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 4p15.3-p15.1

Sequence :: Chromosome: 4; NC_000004.11 (24797085..24802467)

See SOD3 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that NQO2, SOD2 and SOD3 may significantly modify prognosis of breast cancer patients.
Title: Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas.
an alteration in SOD3 expression and activity could be associated to Systemic sclerosis (SSc) fibrosis.
Title: Analysis of extracellular superoxide dismutase in fibroblasts from patients with systemic sclerosis.
Mushroom lectin strongly prevented sodium arsenite-induced damage of SOD production pathway in hepatocytes.
Title: Sodium arsenite-induced alteration in hepatocyte function of rat with special emphasis on superoxide dismutase expression pathway and its prevention by mushroom lectin.
Extracellular superoxide dismutase cell-specific and interferon-gamma-inducible expression in pulmonary artery cells is regulated, to a major degree, by epigenetic mechanisms that include histone acetylation and DNA methylation.
Title: Histone acetylation regulates the cell-specific and interferon-γ-inducible expression of extracellular superoxide dismutase in human pulmonary arteries.
elevated sputum levels in smokers and in COPD patients
Title: Smoking and COPD increase sputum levels of extracellular superoxide dismutase.
Extracellular superoxide dismutase facilitates clearance of bacteria and limits inflammation in response to infection by promoting bacterial phagocytosis.
Title: Extracellular superoxide dismutase in macrophages augments bacterial killing by promoting phagocytosis.
Polymorphisms in human ecSOD have also been reported and it appears logical to assume that such variations may have a profound effect on disease susceptibility.
Title: Allele-specific effects of ecSOD on asbestos-induced fibroproliferative lung disease in mice.
hC-SOD3 has the potential to penetrate and translocate cargo molecules into cells and has no cytotoxicity at effective concentration.
Title: A novel human derived cell-penetrating peptide in drug delivery.
Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells
Title: Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells.
hEC-SOD gene transfer protects against oxidative stress-impaired NO bioavailability in alveolar epithelial cells both in vitro and in the lung in vivo.
Title: The protective effect of overexpression of extracellular superoxide dismutase on nitric oxide bioavailability in the lung after exposure to hyperoxia stress.

Submit: New GeneRIF Correction See all (72)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Superoxide dismutase, elevated extracellular

MIM: 185490

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	Free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuate morphine and gp160-induced human monocyte apoptosis	PubMed
Tat	tat	HIV-1 Tat reduces the expression of MnSOD in several cell types	PubMed
	tat	The membrane transduction efficiencies and biological activities of the SOD protein are enhanced by fusing with the Tat protein transduction domain (PTD) at both termini	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P08294	Q9UBX5	FBLN5		HPRD	PubMed

Function	Evidence Code	Pubs
copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
heparin binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
response to copper ion	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
NOT cytosol	IRD Inferred from Rapid Divergence more info
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info
NOT mitochondrion	IRD Inferred from Rapid Divergence more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info
soluble fraction	TAS Traceable Author Statement more info	PubMed
trans-Golgi network	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: extracellular superoxide dismutase [Cu-Zn]

Names: extracellular superoxide dismutase [Cu-Zn]

NP_003093.2

EC 1.15.1.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012213.1 RefSeqGene

Range

5001..10383

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003102.2 → NP_003093.2 extracellular superoxide dismutase [Cu-Zn] precursor

Status: REVIEWED

Source sequence(s)

AC006390, BC014418, BI757365, BM677660, DA668533

Consensus CDS

CCDS3430.1

UniProtKB/Swiss-Prot

P08294

Related

ENSP00000371554, OTTHUMP00000158715, ENST00000382120, OTTHUMT00000250416

Conserved Domains (1) summary

cd00305
Location:69 – 207
Blast Score: 286

Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

24797085..24802467

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

24139594..24144972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC006390.8 (112366..112393)	None
genomic	AY787834.1	AAV40827.1
genomic	CH471069.1	EAW92823.1
genomic	S71544.1	AAB31336.1
genomic	U10116.1	AAA62278.1
mRNA	AK313935.1	BAG36654.1
mRNA	BC014418.1	AAH14418.1
mRNA	BI757365.1	None
mRNA	BM677660.1	None
mRNA	CR541853.1	CAG46651.1
mRNA	DA668533.1	None
mRNA	J02947.1	AAA66000.1
other-genetic	DQ892086.2	ABM83012.1
other-genetic	DQ895280.2	ABM86206.1