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Tnfaip8l1 tumor necrosis factor, alpha-induced protein 8-like 1 [ Mus musculus (house mouse) ]

Gene ID: 66443, updated on 5-Mar-2024

Summary

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Official Symbol
Tnfaip8l1provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 8-like 1provided by MGI
Primary source
MGI:MGI:1913693
See related
Ensembl:ENSMUSG00000044469 AllianceGenome:MGI:1913693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIPE1; 2600017J23Rik
Summary
Predicted to enable identical protein binding activity. Involved in negative regulation of TOR signaling. Located in cytoplasm. Orthologous to human TNFAIP8L1 (TNF alpha induced protein 8 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 8.7), thymus adult (RPKM 7.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfaip8l1 in Genome Data Viewer
Location:
17 29.19 cM; 17 D
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56469439..56491249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56162439..56184249)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene leucine-rich alpha-2-glycoprotein 1 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene STARR-positive B cell enhancer ABC_E5621 Neighboring gene STARR-positive B cell enhancer ABC_E7547 Neighboring gene myeloid derived growth factor Neighboring gene dipeptidylpeptidase 9 Neighboring gene RIKEN cDNA A230051N06 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy. Zhang X, et al. FEBS J, 2023 Feb. PMID 36111440
  2. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Zhang Z, et al. Oncogene, 2015 May 14. PMID 25043299
  3. The expression of TIPE1 in murine tissues and human cell lines. Cui J, et al. Mol Immunol, 2011 Jul. PMID 21600655
  4. TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. Wu H, et al. Hepatology, 2021 Sep. PMID 33713358
  5. Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy. Liu L, et al. Redox Biol, 2022 Apr. PMID 35152003, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-alpha-Mediated Inflammation.
    Title: Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation.
  2. TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
    Title: TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis mediated autophagy.
  3. TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
    Title: TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
  4. TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
    Title: TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
  5. TIPE1(TNFAIP8-like 1)protein was detected in a variety of tissues such as neurons, brain, hepatocytes, germ cells of female and male reproductive organs, muscular tissues and cells of epithelial origin it was not expressed in mature T or B lymphocytes
    Title: The expression of TIPE1 in murine tissues and human cell lines.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 1
Names
TNF alpha-induced protein 8-like protein 1
TNFAIP8-like protein 1
oxidative stress regulated gene-beta
oxy-beta
tumor necrosis factor, alpha-induced protein 8-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025566.3 → NP_079842.2  tumor necrosis factor alpha-induced protein 8-like protein 1

    See identical proteins and their annotated locations for NP_079842.2

    Status: VALIDATED

    Source sequence(s)
    AK136962, BY733616
    Consensus CDS
    CCDS28897.1
    UniProtKB/Swiss-Prot
    Q3U6E5, Q8K288, Q9D0N6, Q9DBH7
    Related
    ENSMUSP00000076961.7, ENSMUST00000077788.7
    Conserved Domains (1) summary
    pfam05527
    Location:25 → 177
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56469439..56491249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160743.1 → XP_036016636.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U6E5, Q8K288, Q9D0N6, Q9DBH7
    Conserved Domains (1) summary
    pfam05527
    Location:25 → 177
    DUF758; Domain of unknown function (DUF758)

  2. XM_030249985.1 → XP_030105845.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U6E5, Q8K288, Q9D0N6, Q9DBH7
    Conserved Domains (1) summary
    pfam05527
    Location:25 → 177
    DUF758; Domain of unknown function (DUF758)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K288.1 GenPept UniProtKB/Swiss-Prot:Q8K288

Gene LinkOut

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