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BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 663, updated on 26-May-2016
Official Symbol
BNIP2provided by HGNC
Official Full Name
BCL2/adenovirus E1B 19kDa interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:1083
See related
Ensembl:ENSG00000140299 HPRD:04481; MIM:603292; Vega:OTTHUMG00000132727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIP2; BNIP-2
Summary
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Orthologs
Location:
15q22.2
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (59659146..59689529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (59951345..59981728, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene general transcription factor IIA subunit 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H pseudogene 1 Neighboring gene ribosomal protein S3A pseudogene 6 Neighboring gene DEAD-box helicase 18 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • CDO in myogenesis, organism-specific biosystem (from REACTOME)
    CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Myogenesis, organism-specific biosystem (from REACTOME)
    Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029765.2 RefSeqGene

    Range
    4910..35298
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320674.1NP_001307603.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC092755, AI914901, AK308237, BG257875, DC378237
    Conserved Domains (2) summary
    cd00170
    Location:268411
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:168284
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  2. NM_001320675.1NP_001307604.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC092755, AI914901, AK299628
    UniProtKB/Swiss-Prot
    Q12982
    Conserved Domains (2) summary
    cd00170
    Location:209352
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:109225
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  3. NM_004330.3NP_004321.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC092755, AI914901, BC002461, DC378237
    Consensus CDS
    CCDS10174.2
    UniProtKB/Swiss-Prot
    Q12982
    UniProtKB/TrEMBL
    J3KN59
    Related
    ENSP00000479818, ENST00000612191
    Conserved Domains (2) summary
    cd00170
    Location:268411
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:168284
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    59659146..59689529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521955.1XP_011520257.1  

    Conserved Domains (2) summary
    cd00170
    Location:209352
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:143225
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  2. XM_005254607.1XP_005254664.1  

    Conserved Domains (2) summary
    cd00170
    Location:268411
    SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    pfam12496
    Location:168284
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
  3. XM_011521956.1XP_011520258.1  

    Conserved Domains (1) summary
    pfam12496
    Location:168219
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    60073017..60099603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)