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    BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 [ Homo sapiens ]

    Gene ID: 663, updated on 11-May-2012
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    Summary

    Official Symbol
    BNIP2provided by HGNC
    Official Full Name
    BCL2/adenovirus E1B 19kDa interacting protein 2provided by HGNC
    Primary source
    HGNC:1083
    See related
    Ensembl:ENSG00000140299; HPRD:04481; MIM:603292; Vega:OTTHUMG00000132727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIP2; BNIP-2
    Summary
    This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. [provided by RefSeq, Mar 2011]
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    Genomic context

    Location :
    15q22.2
    Sequence :
    Chromosome: 15; NC_000015.9 (59955061..59981642, complement)
    See BNIP2 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene general transcription factor IIA, 2, 12kDa Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H pseudogene Neighboring gene ribosomal protein S3A pseudogene 6 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells. Park G, et al. FEBS Lett, 2011 Jan 3. PMID 21130087.
    4. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. Kelly JL, et al. Cancer Epidemiol Biomarkers Prev, 2010 Nov. PMID 20855536.
    5. Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing. Scott GB, et al. Biochem J, 2010 Nov 1. PMID 20704564.

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2.
      Title: SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells.
    2. Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing.
      Title: Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
    4. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.
      Title: Cleavage of BNIP-2 and BNIP-XL by caspases.
    5. BNIP-2 in vivo induces cell dynamics by recruiting Cdc42
      Title: BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.
    6. BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1
      Title: Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.
    7. Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells
      Title: Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2.
    8. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
      Title: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004321.1 NP_004299.1 ARHGAP1    BIND  PubMed BNIP-2 interacts with Cdc42GAP. 
    NP_004321.1 NP_004299.1 ARHGAP1    BIND  PubMed BNIP-2 interacts with Cdc42GAP. 
    NP_004321.1 NP_004299.1 ARHGAP1    BIND  PubMed BNIP-2 interacts with Cdc42GAP. 
    NP_004321.1 NP_851852.2 ARHGAP8    BIND  PubMed BPGAP1 interacts with BNIP-2. This interaction was modelled on a demonstrated interacton between human BPGAP1 and BNIP-2 from an unspecified species. 
    NP_004321.1 NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with BNIP-2. 
    NP_004321.1 NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with itself. 
    NP_004321.1 NP_612122.1 BNIPL    BIND  PubMed BNIP-S-alpha interacts with BNIP-2. 
    NP_004321.1 CDC42    BIND  PubMed BNIP-2 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species. 
    NP_004321.1 CDC42    BIND  PubMed BNIP-2 interacts with an unspecified isoform of Cdc42. 
    NP_004321.1 CDC42    BIND  PubMed BNIP-2 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species. 
    NP_004321.1     BIND  PubMed Cdc42-GTP interacts with BNIP-2. This interaction was modelled on a demonstrated interaction between Cdc42-GTP from an unspecified species and human BNIP-2. 
    Q12982 Q07960 ARHGAP1    HPRD  PubMed  
    Q12982 P10415 BCL2    HPRD  PubMed  
    Q12982 Q12982 BNIP2    HPRD  PubMed  
    Q12982 Q7Z465 BNIPL    HPRD  PubMed  
    Q12982 P60953 CDC42    HPRD  PubMed  
    Q12982 O43889 CREB3    HPRD  PubMed  
    Q12982 P11362 FGFR1    HPRD  PubMed  
    BioGRID:107131 BioGRID:106885 ARHGAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107131 BioGRID:107068 BCL2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107131 BioGRID:107131 BNIP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107131 BioGRID:127211 BNIPL    BioGRID  PubMed Two-hybrid 
    BioGRID:107131 BioGRID:107433 CDC42    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:107131 BioGRID:115751 CREB3    BioGRID  PubMed Two-hybrid 
    BioGRID:107131 BioGRID:108551 FGFR1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107131 BioGRID:110766 NCBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107131 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    calcium ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    apoptotic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
    Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029765.1 RefSeqGene

      Range
      5001..31582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004330.2 → NP_004321.2  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

      Status: REVIEWED

      Source sequence(s)
      BC002461, BX378770, DC425485
      Consensus CDS
      CCDS10174.2
      UniProtKB/Swiss-Prot
      Q12982
      Related
      ENSP00000267859, OTTHUMP00000163602, ENST00000267859, OTTHUMT00000256069
      Conserved Domains (2) summary
      cd00170
      Location:268 – 411
      Blast Score: 222
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:168 – 284
      Blast Score: 476
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      59955061..59981642, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      36777017..36803599, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC092755.4 (84897..111319) None
    genomic AY268590.1 AAP03429.1
    genomic CH471082.1 EAW77575.1
      EAW77576.1
    mRNA AK299628.1 BAG61556.1
    mRNA AK308237.1 None
    mRNA BC002461.2 AAH02461.1
    mRNA BX378770.2 None
    mRNA DC425485.1 None
    mRNA U15173.1 AAC00021.1
    other-genetic DQ891956.2 ABM82882.1
    other-genetic DQ895142.2 ABM86068.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12982.1 GenPept UniProtKB/Swiss-Prot:Q12982
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
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      Supplemental Content

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