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    SNRPB2 small nuclear ribonucleoprotein polypeptide B [ Homo sapiens ]

    Gene ID: 6629, updated on 11-May-2012

    Summary

    Official Symbol
    SNRPB2provided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Bprovided by HGNC
    Primary source
    HGNC:11155
    See related
    Ensembl:ENSG00000125870; HPRD:04628; MIM:603520; Vega:OTTHUMG00000031933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Msl1; MGC24807; MGC45309
    Summary
    The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    20p12.1
    Sequence :
    Chromosome: 20; NC_000020.10 (16710609..16722417)
    See SNRPB2 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein, large, P0 pseudogene 1 Neighboring gene ribosomal protein L7a pseudogene 13 Neighboring gene otoraplin Neighboring gene proprotein convertase subtilisin/kexin type 2 Neighboring gene dynein light chain Tctex-type 3 pseudogene

    Genomic regions, transcripts, and products

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat U2 snRNPs interact with the HIV-1 Tat cofactor TAT-SF1 and stimulate transcription from the HIV-1 LTR promoter PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P08579 Q08211 DHX9    HPRD  PubMed  
    P08579 O43719 HTATSF1    HPRD  PubMed  
    P08579 Survival of motor neuron 2, centromeric SMN2    HPRD  PubMed  
    P08579 P09661 SNRPA1    HPRD  PubMed  
    BioGRID:112513 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112513 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112513 BioGRID:113826 SF3A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112513 BioGRID:114805 SNRNP40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112513 BioGRID:112511 SNRPA1    BioGRID  PubMed Co-crystal Structure 
    BioGRID:112513 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112513 BioGRID:212207 Sf3a1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112513 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the SNRPB2 gene: The SNRPB2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, U2-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, U2-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    snRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    U2 snRNP TAS
    Traceable Author Statement
    more info
    PubMed 
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    U2 small nuclear ribonucleoprotein B''
    Names
    U2 small nuclear ribonucleoprotein B''
    U2 snRNP B''
    small nuclear ribonucleoprotein polypeptide B2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003092.4NP_003083.1  U2 small nuclear ribonucleoprotein B''

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI741327, BC018022, BM772256, DA088017
      Consensus CDS
      CCDS13123.1
      UniProtKB/Swiss-Prot
      P08579
      Related
      ENSP00000246071, OTTHUMP00000030324, ENST00000246071, OTTHUMT00000078110
      Conserved Domains (1) summary
      cd00590
      Location:883
      Blast Score: 159
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
    2. NM_198220.2NP_937863.1  U2 small nuclear ribonucleoprotein B''

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI741327, BC036737, BM772256, DA088017
      Consensus CDS
      CCDS13123.1
      UniProtKB/Swiss-Prot
      P08579
      Related
      ENSP00000367178, OTTHUMP00000030325, ENST00000377943, OTTHUMT00000078111
      Conserved Domains (1) summary
      cd00590
      Location:883
      Blast Score: 159
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      16710609..16722417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      16673454..16685262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL034428.4 CAB38777.2
    genomic CH471133.3 EAX10284.1
      EAX10285.1
      EAX10286.1
    mRNA AA953215.1 None
    mRNA AB451234.1 BAG70048.1
    mRNA AB451359.1 BAG70173.1
    mRNA AI741327.1 None
    mRNA AK313004.1 BAG35840.1
    mRNA BC008311.1 AAH08311.1
    mRNA BC018022.1 AAH18022.1
    mRNA BC022311.1 None
    mRNA BC036737.2 AAH36737.1
    mRNA BF243328.1 None
    mRNA BM772256.1 None
    mRNA DA088017.1 None
    mRNA M15841.1 AAA36796.1
    other-genetic DQ890864.2 ABM81790.1
    other-genetic DQ894019.2 ABM84945.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08579.1 GenPept UniProtKB/Swiss-Prot:P08579
    Q86YK2 GenPept UniProtKB/TrEMBL:Q86YK2

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