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    SNAP25 synaptosomal-associated protein, 25kDa [ Homo sapiens ]

    Gene ID: 6616, updated on 11-May-2012
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    Summary

    Official Symbol
    SNAP25provided by HGNC
    Official Full Name
    synaptosomal-associated protein, 25kDaprovided by HGNC
    Primary source
    HGNC:11132
    See related
    Ensembl:ENSG00000132639; HPRD:02637; MIM:600322; Vega:OTTHUMG00000031863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RIC4; SEC9; SNAP; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2; FLJ23079
    Summary
    Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    20p12-p11.2
    Sequence :
    Chromosome: 20; NC_000020.10 (10199477..10288065)
    See SNAP25 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene p21 protein (Cdc42/Rac)-activated kinase 7 Neighboring gene uncharacterized LOC100131208 Neighboring gene ankyrin repeat domain 5 Neighboring gene HIG1 domain family member 1A-like Neighboring gene ribosomal protein L23a pseudogene 6

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Fibronectin enhances soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein expression in cultured human islets. Fernández-Montes RD, et al. Pancreas, 2011 Oct. PMID 21926557.
    2. Molecular mechanism of cholesterol- and polyphosphoinositide-mediated syntaxin clustering. Murray DH, et al. Biochemistry, 2011 Oct 25. PMID 21916482.
    3. Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy. Basoglu C, et al. Can J Psychiatry, 2011 Jun. PMID 21756448.
    4. Haplotyping of putative microRNA-binding sites in the SNAP-25 gene. Kovacs-Nagy R, et al. Electrophoresis, 2011 Aug. PMID 21557260.
    5. Regional and developmental brain expression patterns of SNAP25 splice variants. Prescott GR, et al. BMC Neurosci, 2011 Apr 28. PMID 21526988.

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This article confirms and expands previous studies suggesting that genes moderate ADHD treatment response. The ADHD outcomes are not unitary but reflect both behavioral and learning domains that are likely influenced by different genes.
      Title: A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorder.
    2. Letter: incubation of pancreatic islets with fibronectin improves beta cell function via increased expression of syntaxin 1 and SNAP25.
      Title: Fibronectin enhances soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein expression in cultured human islets.
    3. Forming an acceptor SNARE complex between syntaxin-1A and SNAP-25 weakens but does not abrogate cholesterol-controlled cluster formation and indicates that the reconstitution process results in equal incorporation of protein at either lipid composition.
      Title: Molecular mechanism of cholesterol- and polyphosphoinositide-mediated syntaxin clustering.
    4. DdeI and MnII T/T genotypes of SNAP25 may be a risk factor for antisocial behavior in a Turkish population.
      Title: Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy.
    5. An association is identified between SNAP-25 and attention-deficit hyperactivity disorder (ADHD) in Chinese subjects of Han descent: SNAP-25 is a genetic susceptibility factor for ADHD.
      Title: An association study between SNAP-25 gene and attention-deficit hyperactivity disorder.
    6. Prescence of of APOEepsilon4 allele and MAPT H2 haplotype in frontotemporal lobar degeneration had a significant influence on the expression of synaptophysin and SNAP-25
      Title: Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype.
    7. The study shows that SNAP25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.
      Title: SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.
    8. A novel real-time PCR-based technique was used applying sequence specific TaqMan probes to haplotype the two SNPs. In silico analyses have suggested that the two SNPs might alter microRNA binding and thus have an effect on SNAP-25 production.
      Title: Haplotyping of putative microRNA-binding sites in the SNAP-25 gene.
    9. SNAP25a and SNAP25b display distinct developmental and regional expression profiles in rat and human brain.
      Title: Regional and developmental brain expression patterns of SNAP25 splice variants.
    10. findings explain how N-terminal light chain (LC)/A associates with SNAP-25 on the plasma membrane and provide a basis for LC/A cleavage of SNAP-25 within the SNARE complex
      Title: Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25.
    Submit: New GeneRIF Correction See all (62)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P60880 P49454 CENPF    HPRD  PubMed  
    P60880 Q05193 DNM1    HPRD  PubMed  
    P60880 O14964 HGS    HPRD  PubMed  
    P60880 Q15811 ITSN1    HPRD  PubMed  
    P60880 Q14721 KCNB1    HPRD  PubMed  
    P60880 P33176 KIF5B    HPRD  PubMed  
    P60880 P17612 PRKACA    HPRD  PubMed  
    P60880 P17252 PRKCA    HPRD  PubMed  
    P60880 Proline-rich transmembrane protein 2 PRRT2    HPRD  PubMed  
    P60880 Q86UR5 RIMS1    HPRD  PubMed  
    P60880 O95295 SNAPIN    HPRD  PubMed  
    P60880 Q9C0H9 SRCIN1    HPRD  PubMed  
    P60880 O75558 STX11    HPRD  PubMed  
    P60880 Q86Y82 STX12    HPRD  PubMed  
    P60880 Q16623 STX1A    HPRD  PubMed  
    P60880 P32856 STX2    HPRD  PubMed  
    P60880 Q13277 STX3    HPRD  PubMed  
    P60880 Q12846 STX4    HPRD  PubMed  
    P60880 Q8NFX7 STXBP6    HPRD  PubMed  
    P60880 P21579 SYT1    HPRD  PubMed  
    P60880 Q9BQG1 SYT3    HPRD  PubMed  
    P60880 Q86SS6 SYT9    HPRD  PubMed  
    P60880 Q9C026 TRIM9    HPRD  PubMed  
    P60880 P63027 VAMP2    HPRD  PubMed  
    P60880 P51809 VAMP7    HPRD  PubMed  
    P60880 Q9BV40 VAMP8    HPRD  PubMed  
    P60880 Q8IUH5 ZDHHC17    HPRD  PubMed  
    BioGRID:112500 BioGRID:116028 CPLX1    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:112500 BioGRID:114903 GOSR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:112351 ITSN1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112500 BioGRID:109947 KCNB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:110000 KIF5B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112500 BioGRID:114305 NAPA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:125188 PRRT2    BioGRID  PubMed Two-hybrid 
    BioGRID:112500 BioGRID:114899 SCAMP1    BioGRID  PubMed Reconstituted Complex 
    NP_036569.1 SNAPIN    BIND  PubMed SNAP25 interacts with Snapin. 
    BioGRID:112500 BioGRID:117101 SNAPIN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112500 BioGRID:123275 SRCIN1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112500 BioGRID:114224 STX11    BioGRID  PubMed Two-hybrid 
    BioGRID:112500 BioGRID:117191 STX12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112500 BioGRID:112676 STX1A    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:112500 BioGRID:108368 STX2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:112678 STX3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:112679 STX4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112500 BioGRID:112680 STX5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:112723 SYT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:123985 SYT3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112500 BioGRID:125280 TRIM9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112500 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112500 BioGRID:115759 UNC13B    BioGRID  PubMed Co-fractionation 
    BioGRID:112500 BioGRID:112711 VAMP2    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112500 BioGRID:112712 VAMP7    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Acetylcholine Neurotransmitter Release Cycle, organism-specific biosystemAcetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then...
    • BoNT Light Chain Types A, C1, E cleave SNAP-25, organism-specific biosystem (from REACTOME)
      BoNT Light Chain Types A, C1, E cleave SNAP-25, organism-specific biosystemBoNTs of serotypes A, C1 and E cleave SNAP-25 (synaptosomal-associated protein, 25kDa), a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. BoNT A removes ni...
    • Botulinum neurotoxicity, organism-specific biosystem (from REACTOME)
      Botulinum neurotoxicity, organism-specific biosystemBotulism, caused by botulinum neurotoxin (BoNT), is characterized by descending flaccid paralysis as a result of inhibition of neurotransmitter release at the neuromuscular junction - NMJ (Turton et ...
    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Dopamine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Dopamine Neurotransmitter Release Cycle, organism-specific biosystemDopamine neurotransmitter cycle occurs in dopaminergic neurons. Dopamine is synthesized and loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and fused w...
    • Effects of Botulinum toxin, organism-specific biosystem (from Pathway Interaction Database)
      Effects of Botulinum toxin, organism-specific biosystem
      Effects of Botulinum toxin
    • GABA synthesis, release, reuptake and degradation, organism-specific biosystem (from REACTOME)
      GABA synthesis, release, reuptake and degradation, organism-specific biosystemGABA is a major inhibitory neurotransmitter in the mammalian central nervous system. GABA modulates neuronal excitability throughout the nervous system. Disruption of GABA neurotransmission leads to ...
    • Glutamate Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Glutamate Neurotransmitter Release Cycle, organism-specific biosystemCommunication at the synapse involves the release of glutamate from the presynaptic neuron and its binding to glutamate receptors on the postsynaptic cell to generate a series of events that lead to ...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin Synthesis and Processing, organism-specific biosystem (from REACTOME)
      Insulin Synthesis and Processing, organism-specific biosystemThe generation of insulin-containing secretory granules from proinsulin in the lumen of the endoplasmic reticulum (ER) can be described in 4 steps: formation of intramolecular disulfide bonds, format...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Neurotransmitter Release Cycle, organism-specific biosystemNeurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotr...
    • Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Norepinephrine Neurotransmitter Release Cycle, organism-specific biosystemNoradrenalin release cycle consists of reacidification of the empty clathrin sculpted monoamine transport vesicle, loading of dopamine into reacidified clathrin coated monamine transport vesicle, con...
    • Proteolytic cleavage of SNARE complex proteins, organism-specific biosystem (from REACTOME)
      Proteolytic cleavage of SNARE complex proteins, organism-specific biosystemVAMP/synaptobrevin, SNAP-25 and syntaxin are important for synaptic vesicle fusion at the nerve terminal. These proteins constitute the synaptic members of SNARE family (soluble N-ethylmaleimide-sen...
    • Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
      Regulation of Insulin Secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...
    • SNARE interactions in vesicular transport, organism-specific biosystem (from KEGG)
      SNARE interactions in vesicular transport, organism-specific biosystem
      SNARE interactions in vesicular transport
    • SNARE interactions in vesicular transport, conserved biosystem (from KEGG)
      SNARE interactions in vesicular transport, conserved biosystem
      SNARE interactions in vesicular transport
    • Serotonin Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Serotonin Neurotransmitter Release Cycle, organism-specific biosystemSerotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoa...
    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SNARE binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    myosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein N-terminus binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium ion-dependent exocytosis of neurotransmitter IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    energy reserve metabolic process TAS
    Traceable Author Statement
    more info
    		  
    glutamate secretion TAS
    Traceable Author Statement
    more info
    		  
    growth hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		  
    neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		  
    neurotransmitter uptake NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of insulin secretion TAS
    Traceable Author Statement
    more info
    		  
    regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    sleep IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    synaptic vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    axonal growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    synaptosomal-associated protein 25
    Names
    synaptosomal-associated protein 25
    SUP
    super protein
    resistance to inhibitors of cholinesterase 4 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029626.1 RefSeqGene

      Range
      5001..93590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003081.3 → NP_003072.2  synaptosomal-associated protein 25 isoform SNAP25A

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains 8 exons and encodes isoform SNAP25A.
      Source sequence(s)
      BC010647, BI552777, BI602062, BX647443
      Consensus CDS
      CCDS13109.1
      UniProtKB/Swiss-Prot
      P60880
      Related
      ENSP00000307341, OTTHUMP00000030268, ENST00000304886, OTTHUMT00000077977
      Conserved Domains (2) summary
      cd00193
      Location:143 – 202
      Blast Score: 123
      t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
      pfam00835
      Location:91 – 141
      Blast Score: 149
      SNAP-25; SNAP-25 family

    2. NM_130811.2 → NP_570824.1  synaptosomal-associated protein 25 isoform SNAP25B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon 5 as compared to transcript variant 1. This results in an isoform (SNAP25B) that is the same length, and contains the same N- and C-termini as isoform SNAP25A, but has 9 aa differences internally.
      Source sequence(s)
      BC010647, BI552777, BI602062, BX647443, D21267
      Consensus CDS
      CCDS13110.1
      UniProtKB/Swiss-Prot
      P60880
      Related
      ENSP00000254976, OTTHUMP00000030267, ENST00000254976, OTTHUMT00000077976
      Conserved Domains (2) summary
      cd00193
      Location:143 – 202
      Blast Score: 123
      t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
      pfam00835
      Location:91 – 141
      Blast Score: 150
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      10199477..10288065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      10151237..10239825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL023913.6 CAB42860.1
      CAC34534.1
      CAD56158.1
    genomic AL354824.8 (76311..83950) None
    genomic CH471133.3 EAX10346.1
      EAX10347.1
      EAX10348.1
      EAX10349.1
      EAX10350.1
      EAX10351.1
      EAX10352.1
      EAX10353.1
    mRNA AK026732.1 None
    mRNA AK090857.1 None
    mRNA AK094560.1 None
    mRNA AK098347.1 None
    mRNA AK098767.1 None
    mRNA AK223617.1 BAD97337.1
    mRNA AK289647.1 BAF82336.1
    mRNA AK314359.1 BAG36991.1
    mRNA BC010647.1 AAH10647.1
    mRNA BI552777.1 None
    mRNA BI602062.1 None
    mRNA BI604120.1 None
    mRNA BT019684.1 AAV38490.1
    mRNA BX647443.1 None
    mRNA D21267.1 BAA22370.1
    mRNA L19760.1 AAC37545.1
    mRNA L19761.1 AAC37546.1
    other-genetic AM393230.1 CAL38108.1
    other-genetic AM393653.1 CAL38529.1
    other-genetic HQ447952.1 ADQ32436.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60880.1 GenPept UniProtKB/Swiss-Prot:P60880
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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      Supplemental Content

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