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SNAI1 snail family zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 6615, updated on 26-Aug-2014
Official Symbol
SNAI1provided by HGNC
Official Full Name
snail family zinc finger 1provided by HGNC
Primary source
HGNC:11128
See related
Ensembl:ENSG00000124216; HPRD:05025; MIM:604238; Vega:OTTHUMG00000033048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNA; SNAH; SNAIL; SLUGH2; SNAIL1; dJ710H13.1
Summary
The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]
See SNAI1 in Epigenomics, MapViewer
Location:
20q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (49982976..49988886)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48599513..48605423)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 114 Neighboring gene keratin 18 pseudogene 4 Neighboring gene translation regulatory long non-coding RNA 1 Neighboring gene TMEM189-UBE2V1 readthrough Neighboring gene ubiquitin-conjugating enzyme E2 variant 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies three psoriasis susceptibility loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu leads to the depression of both total and beta-catenin-associated E-cadherin levels through Vpu-induced upregulation of the transcriptional repressor Snail PubMed
vpu HIV-1 Vpu upregulates the expression of Snail in HeLa cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling involved in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
cartilage morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
left/right pattern formation IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vitamin D biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
 
palate development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 
regulation of tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
trophoblast giant cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
zinc finger protein SNAI1
Names
zinc finger protein SNAI1
protein sna
snail 1 homolog
snail homolog 1
protein snail homolog 1
snail 1 zinc finger protein
snail 1, zinc finger protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005985.3NP_005976.2  zinc finger protein SNAI1

    See proteins identical to NP_005976.2

    Status: REVIEWED

    Source sequence(s)
    BC012910, DA972913
    Consensus CDS
    CCDS13423.1
    UniProtKB/Swiss-Prot
    O95863
    Related
    ENSP00000244050, OTTHUMP00000031680, ENST00000244050, OTTHUMT00000080350
    Conserved Domains (3) summary
    COG5048
    Location:177253
    Blast Score: 98
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:208230
    Blast Score: 80
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:195218
    Blast Score: 97
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    49982976..49988886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    45348282..45354192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    48504120..48510030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)