Apoa5 apolipoprotein A-V [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Apoa5provided by MGI
Official Full Name: apolipoprotein A-Vprovided by MGI
Primary source: MGI:1913363
See related: Ensembl:ENSMUSG00000032079; Vega:OTTMUSG00000028704
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAP3; Apoav; 1300007O05Rik

Genomic context

Go to the top of the page Help

Location :: 9; 9 B

Sequence :: Chromosome: 9; NC_000075.6 (46268608..46271919)

See Apoa5 in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene transfer of human apoA-V improves the severe hypertriglyceridemia phenotype of apoa5 null mice.
Title: Gene transfer of apolipoprotein A-V improves the hypertriglyceridemic phenotype of apoa5 (-/-) mice.
Intravenously injected apoA-V rHDL significantly lowers plasma TG in an apoA-V deficient mouse model and requires gpihbp1.
Title: Intravenous injection of apolipoprotein A-V reconstituted high-density lipoprotein decreases hypertriglyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1.
Data show that livers from apolipoprotein A-V (APOA-V) transgenic mice contain significantly higher amounts of triglycerides than livers from wild-type or apoA-V knockout mice, suggesting that apoA-V influences intrahepatic triglyceride levels.
Title: Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation.
Preferential association of apoA-V(1-146) with murine plasma HDL, but not with VLDL, suggests that particle size is a determinant of its lipoprotein binding specificity.
Title: Apolipoprotein A-V N-terminal domain lipid interaction properties in vitro explain the hypertriglyceridemic phenotype associated with natural truncation mutants.
These findings are consistent with the presence of a functional PPAR-binding element in the promoter of the human APOA5 gene; this element is however degenerate and non-functional in the corresponding mouse Apoa5 sequence.
Title: Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice.
Data suggest that higher plasma apolipoprotein AV levels reflect an increased demand for plasma triglyceride hydrolysis under normal physiological conditions.
Title: Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.
the apoCIII enhancer contributes to the maintenance of an active chromatin subdomain of the apoAI/CIII/AIV genes, but not apoAV
Title: The apolipoprotein CIII enhancer regulates both extensive histone modification and intergenic transcription of human apolipoprotein AI/CIII/AIV genes but not apolipoprotein AV.
oxidized fatty acids may act through an APOA5/APOClll mechanism that contributes to lowering of TG levels other than PPAR* induction
Title: Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms.
and metabolic consequences and phenotype of the three APOA5 mutations reported to date, which lead to premature truncations of apoAV are described
Title: Rare APOA5 mutations--clinical consequences, metabolic and functional effects: an ENID review.
These data suggest that in addition to its TG-lowering effect, apoA-V plays a significant role in modulating HDL maturation and cholesterol metabolism.
Title: Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice.

Submit: New GeneRIF Correction See all (20)

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation

Pathways from BioSystems

Go to the top of the page Help

Chylomicron-mediated lipid transport, organism-specific biosystem (from REACTOME)
Chylomicron-mediated lipid transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
Lipid digestion, mobilization, and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
Lipoprotein metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem (from LIPID MAPS)
PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem
PPAR (Peroxisome proliferator-activated receptor) signaling pathway
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, organism-specific biosystem (from WikiPathways)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Homology

Homologs of the Apoa5 gene: The Apoa5 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enzyme activator activity	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
heparin binding	ISO Inferred from Sequence Orthology more info
lipase activator activity	ISO Inferred from Sequence Orthology more info
lipase binding	ISO Inferred from Sequence Orthology more info
lipid binding	ISO Inferred from Sequence Orthology more info
lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acylglycerol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acylglycerol homeostasis	ISO Inferred from Sequence Orthology more info
cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
lipid transport	ISO Inferred from Sequence Orthology more info
lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
transport	IEA Inferred from Electronic Annotation more info
triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
triglyceride-rich lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
chylomicron	ISO Inferred from Sequence Orthology more info
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	ISO Inferred from Sequence Orthology more info
high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: apolipoprotein A-V

Names: apolipoprotein A-V; apo-AV; apoA-V; apolipoprotein A5; regeneration-associated protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080434.3 → NP_536682.2 apolipoprotein A-V precursor

Status: PROVISIONAL

Source sequence(s)

AK050280

Consensus CDS

CCDS23143.1

UniProtKB/Swiss-Prot

Q8C7G5

Related

ENSMUSP00000034584, ENSMUST00000034584

Conserved Domains (1) summary

pfam01442
Location:52 – 252
Blast Score: 367

Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38.p1 C57BL/6J

Range

46268608..46271919

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

43557616..43560927

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01077765.1 (6829..10140)	None
genomic	AC164105.4 (173154..176465)	None
genomic	CH466522.1	EDL25685.1	mixed
mRNA	AF327059.1	AAG49600.1	C57BL
mRNA	AK004903.1	None	C57BL/6J
mRNA	AK004936.1	None	C57BL/6J
mRNA	AK050280.1	BAC34163.1	C57BL/6J
mRNA	BC011198.1	AAH11198.1	FVB/N
mRNA	BC029334.1	None	FVB/N