Cxcl16 chemokine (C-X-C motif) ligand 16 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cxcl16provided by MGI
Official Full Name: chemokine (C-X-C motif) ligand 16provided by MGI
Primary source: MGI:1932682
Locus tag: DN-491F10.6
See related: Ensembl:ENSMUSG00000018920; Vega:OTTMUSG00000006042
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SR-PSOX; Zmynd15; AV290116; BB024863; CXCL16v1; CXCL16v2; b2b498Clo; 0910001K24Rik

Genomic context

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Location :: 11; 11 B4

Sequence :: Chromosome: 11; NC_000077.6 (70454234..70459984, complement)

See Cxcl16 in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Renal dendritic cell-derived CXCL16 might attract protective CXCR6(+) iNKT cells.
Title: Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
CXCL16 triggers platelet activation and adhesion via CXCR6 phosphatidylinositide 3-kinase/Akt signaling and paracrine activation, suggesting a decisive role for CXCL16 in linking vascular inflammation and thrombo-occlusive diseases.
Title: The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling.
TWEAK upregulates the expression of the chemokine CXCL16 in tubular epithelium and this may contribute to kidney tubulointerstitial inflammation.
Title: TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation.
Induction of experimental autoimmune encephalomyelitis leads to expression of CXCL10 and CXCL16 in immature myeloid cells of draining lymph nodes, in an interferon (IFN)-gamma-dependent manner.
Title: Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system.
regulation of CXCL16, ADAM10 and oxLDL expression may be an early event in the onset of diabetic nephropathy
Title: CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.
contributes to the pathogenesis of renal fibrosis by recruiting bone marrow-derived fibroblast precursors
Title: CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis.
Data show that CXCL16 becomes much higher in atherosclerosis, and it could be a potential atherogenic biomarker.
Title: Overexpression of CXCL16 promotes a vulnerable plaque phenotype in Apolipoprotein E-Knockout Mice.
This study implicates CXCL16 as an additional neutrophil chemoattractant in cerebrospinal fluid in early pneumococcal meningitis.
Title: CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis.
An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells.
Title: An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells.
Overall, our data indicate that up-regulation of CXCL16 is a common response of tumor cells to radiation, and they have important implications for the use of local radiotherapy in combination with immunotherapy.
Title: Up-regulation of the pro-inflammatory chemokine CXCL16 is a common response of tumor cells to ionizing radiation.

Submit: New GeneRIF Correction See all (28)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation
Chemically induced (ENU) (1)

Pathways from BioSystems

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Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Homology

Homologs of the Cxcl16 gene: The Cxcl16 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
chemokine activity	IDA Inferred from Direct Assay more info	PubMed
chemokine activity	ISO Inferred from Sequence Orthology more info
cytokine activity	IEA Inferred from Electronic Annotation more info
low-density lipoprotein receptor activity	IDA Inferred from Direct Assay more info	PubMed
scavenger receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
chemotaxis	IEA Inferred from Electronic Annotation more info
lymphocyte chemotaxis	IEA Inferred from Electronic Annotation more info
positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
response to interferon-gamma	ISO Inferred from Sequence Orthology more info
response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
extracellular space	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 16

Names: C-X-C motif chemokine 16; SR-PSOX/CXCL16; Cxc chemokine ligand 16; small-inducible cytokine B16; transmembrane chemokine CXCL16; zinc finger, MYND-type containing 15; scavenger receptor for phosphatidylserine and oxidized low density lipoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023158.6 → NP_075647.3 C-X-C motif chemokine 16 precursor

Status: PROVISIONAL

Source sequence(s)

AK028875

Consensus CDS

CCDS24948.1

UniProtKB/Swiss-Prot

Q8BSU2

Related

ENSMUSP00000019064, OTTMUSP00000006308, ENSMUST00000019064, OTTMUST00000013602

Conserved Domains (1) summary

COG1429
Location:114 – 211
Blast Score: 91

CobN; Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

70454234..70459984, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 NOD/MrkTac

Genomic

NT_187026.1 Reference GRCm38.p1 NOD/MrkTac

Range

558669..564419, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

78000199..78005953, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01094215.1 (30279..36033)	None
genomic	AL596096.7 (136811..142561)	None
genomic	CH466596.1	EDL12565.1	mixed
		EDL12566.1	mixed
		EDL12567.1	mixed
genomic	CR936841.11	CAM28188.1
		CAM28189.1
mRNA	AF277001.1	AAG31754.1
mRNA	AF301017.1	AAG34366.1	C57BL/6
mRNA	AK003085.1	None	C57BL/6J
mRNA	AK009599.1	BAB26384.1	C57BL/6J
mRNA	AK028875.1	BAC26166.1	C57BL/6J
mRNA	AK030515.1	BAC27000.1	C57BL/6J
mRNA	AK150224.1	BAE29391.1	C57BL/6J
mRNA	AK151330.1	BAE30309.1	C57BL/6J
mRNA	AK152102.1	BAE30949.1	C57BL/6J
mRNA	AK152547.1	BAE31302.1	C57BL/6J
mRNA	AK153192.1	BAE31792.1	C57BL/6J
mRNA	AK170428.1	None	NOD
mRNA	BC019961.1	AAH19961.1	CZECHII
mRNA	GQ380016.1	ADD14004.1	C57BL/6
mRNA	GQ380017.1	ADD14005.1	C57BL/6