POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa [Homo sapiens] - Gene

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Summary

Official Symbol: POLR3Dprovided by HGNC
Official Full Name: polymerase (RNA) III (DNA directed) polypeptide D, 44kDaprovided by HGNC
Primary source: HGNC:1080
See related: Ensembl:ENSG00000168495; HPRD:01755; MIM:187280; Vega:OTTHUMG00000163778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RPC4; BN51T; RPC53; TSBN51
Summary: This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 8q21

Sequence :: Chromosome: 8; NC_000008.10 (22102619..22108680)

See POLR3D in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P05423	Q9NVU0	POLR3E	HPRD	PubMed
BioGRID:107129	BioGRID:106825	APEX1	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:106957	ATF3	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:109423	HNRNPAB	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:109446	HOXA10	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:109465	HOXC9	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:109544	HSPA8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:111586	MAPK11	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:110594	MSX2	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:115320	NR2E3	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:247522	Nedd4	BioGRID	PubMed	Biochemical Activity
BioGRID:107129	BioGRID:114909	POLR1C	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:119272	POLR1D	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:111430	POLR2E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:111431	POLR2F	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:111433	POLR2H	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:116301	POLR3A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:120828	POLR3B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:115868	POLR3C	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:120840	POLR3E	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107129	BioGRID:115866	POLR3F	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:115867	POLR3G	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:128147	POLR3H	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:119701	POLR3K	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:117087	RBFOX2	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:124119	RHOXF2	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:115717	TAB1	BioGRID	PubMed	Two-hybrid
BioGRID:107129	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107129	BioGRID:124291	ZNF496	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
DNA-directed RNA polymerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
gene expression	TAS Traceable Author Statement more info
positive regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
response to virus	IEA Inferred from Electronic Annotation more info
termination of RNA polymerase III transcription	TAS Traceable Author Statement more info
transcription elongation from RNA polymerase III promoter	TAS Traceable Author Statement more info
transcription from RNA polymerase III promoter	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
DNA-directed RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: DNA-directed RNA polymerase III subunit RPC4

Names: DNA-directed RNA polymerase III subunit RPC4; RPC53 homolog; RNA polymerase III subunit C4; RNA polymerase III 47 kDa subunit; DNA-directed RNA polymerase III subunit D; BN51 (BHK21) temperature sensitivity complementing; DNA-directed RNA polymerase III 47 kDa polypeptide; temperature sensitive complementation, cell cycle specific, tsBN51

NP_001713.2

EC 2.7.7.6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001722.2 → NP_001713.2 DNA-directed RNA polymerase III subunit RPC4

Status: REVIEWED

Source sequence(s)

AK026588, AY092086, BQ006609

Consensus CDS

CCDS34858.1

UniProtKB/Swiss-Prot

P05423

Related

ENSP00000303088, OTTHUMP00000224864, ENST00000306433, OTTHUMT00000375432

Conserved Domains (1) summary

pfam05132
Location:262 – 389
Blast Score: 379

RNA_pol_Rpc4; RNA polymerase III RPC4

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

22102619..22108680

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

20644813..20650874

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC105206.8 (36681..42742)	None
genomic	CH471080.2	EAW63689.1
		EAW63690.1
		EAW63691.1
		EAW63692.1
genomic	L15301.1	AAA72377.1
mRNA	AF346574.1	AAK15371.1
mRNA	AK026588.1	None
mRNA	AK295725.1	BAG58566.1
mRNA	AY092086.1	AAM18216.1
mRNA	BC000516.2	None
mRNA	BC002603.2	AAH02603.1
mRNA	BC003039.1	None
mRNA	BC004484.2	AAH04484.1
mRNA	BQ006609.1	None
mRNA	CR536509.1	CAG38747.1
mRNA	CR541803.1	CAG46602.1
mRNA	M17754.1	AAA51838.1
other-genetic	HQ447310.1	ADQ31797.1