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Ido1 indoleamine 2,3-dioxygenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 66029, updated on 26-May-2016
Official Symbol
Ido1provided by RGD
Official Full Name
indoleamine 2,3-dioxygenase 1provided by RGD
Primary source
RGD:619989
See related
Ensembl:ENSRNOG00000031189
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ido; Indo
Summary
enzyme which catalyzes degradation of L-tryptophan to N-formylkynurenine; human homolog is induced by gamma-interferon and is believed to be involved in that agent's tumor antiproliferative effects [RGD, Feb 2006]
Orthologs
Location:
16q12.5
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (72216326..72228098)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (71866330..71878339)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 3A Neighboring gene ADAM metallopeptidase domain 18 Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene uncharacterized LOC103693990

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
indoleamine 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
indoleamine 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
indoleamine 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
tryptophan 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
kynurenic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
kynurenic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal response to stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell tolerance induction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chronic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type 2 immune response ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
swimming behavior IEA
Inferred from Electronic Annotation
more info
 
swimming behavior ISO
Inferred from Sequence Orthology
more info
 
tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
PubMed 
tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
 
tryptophan catabolic process to kynurenine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle contractile fiber IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contractile fiber ISO
Inferred from Sequence Orthology
more info
 
stereocilium bundle IEA
Inferred from Electronic Annotation
more info
 
stereocilium bundle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
indoleamine 2,3-dioxygenase 1
Names
IDO-1
indoleamine 23-dioxygenase
indoleamine-pyrrole 2,3 dioxygenase
indoleamine-pyrrole 2,3-dioxygenase
NP_076463.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023973.1NP_076463.1  indoleamine 2,3-dioxygenase 1

    See identical proteins and their annotated locations for NP_076463.1

    Status: PROVISIONAL

    Source sequence(s)
    AF312699
    UniProtKB/Swiss-Prot
    Q9ERD9
    Related
    ENSRNOP00000050320, ENSRNOT00000051363
    Conserved Domains (1) summary
    pfam01231
    Location:12404
    IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    72216326..72228098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    65330156..65341814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)