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    SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 [ Homo sapiens ]

    Gene ID: 6601, updated on 11-May-2012

    Summary

    Official Symbol
    SMARCC2provided by HGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2provided by HGNC
    Primary source
    HGNC:11105
    See related
    Ensembl:ENSG00000139613; HPRD:03437; MIM:601734; Vega:OTTHUMG00000170288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Rsc8; BAF170; CRACC2; DKFZp313D0632
    Summary
    The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    12q13.2
    Sequence :
    Chromosome: 12; NC_000012.11 (56555636..56583351, complement)
    See SMARCC2 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene myosin, light chain 6B, alkali, smooth muscle and non-muscle Neighboring gene myosin, light chain 6, alkali, smooth muscle and non-muscle Neighboring gene ring finger protein 41 Neighboring gene oligonucleotide/oligosaccharide-binding fold containing 2B

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_620706.1 NC_000003.9 GRM2    BIND  PubMed BAF170 interacts with mGluR2 promoter. 
    NP_620706.1 NC_000008.9 STMN2    BIND  PubMed BAF170 interacts with SCG10 promoter. 
    Q8TAQ2 P32121 ARRB2    HPRD  PubMed  
    Q8TAQ2 P54253 ATXN1    HPRD  PubMed  
    Q8TAQ2 Q15811 ITSN1    HPRD  PubMed  
    Q8TAQ2 P51513 NOVA1    HPRD  PubMed  
    Q8TAQ2 O75381 PEX14    HPRD  PubMed  
    Q8TAQ2 Q92561 PHYHIP    HPRD  PubMed  
    Q8TAQ2 P19387 POLR2C    HPRD  PubMed  
    Q8TAQ2 Q01201 RELB    HPRD  PubMed  
    Q8TAQ2 O43295 SRGAP3    HPRD  PubMed  
    BioGRID:112485 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:116967 ADNP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:1147430 ALL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:113894 ARID1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:121559 ARID1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:128219 ARID2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:106902 ARRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:112485 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:107140 BRCA1    BioGRID  PubMed Co-purification 
    BioGRID:112485 BioGRID:118883 BRD7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:198328 Bcl7b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:112485 BioGRID:107458 CDK8    BioGRID  PubMed Co-fractionation 
    BioGRID:112485 BioGRID:120775 CHD7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:111909 DPF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:108893 GATA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112485 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:113036 HSP90B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112351 ITSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:112485 BioGRID:115984 KDM5B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:115904 KLF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112485 BioGRID:110036 KPNA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:122776 MCPH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112485 BioGRID:114973 NCOR1    BioGRID  PubMed Co-purification 
    BioGRID:112485 BioGRID:120490 PBRM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:111218 PEX14    BioGRID  PubMed Two-hybrid 
    BioGRID:112485 BioGRID:120562 PHF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:115139 PHYHIP    BioGRID  PubMed Two-hybrid 
    BioGRID:112485 BioGRID:111428 POLR2C    BioGRID  PubMed Two-hybrid 
    BioGRID:112485 BioGRID:116796 RCOR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:111903 RELB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:111910 REST    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112485 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112485 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112485 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:112486 SMARCD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112485 BioGRID:112487 SMARCD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112488 SMARCD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112489 SMARCE1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112485 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112550 SP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112485 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112650 STAT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112747 TAF13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112485 BioGRID:112761 TAT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112485 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112485 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    npBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with transcriptional repressor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    SWI/SNF complex subunit SMARCC2
    Names
    SWI/SNF complex subunit SMARCC2
    SWI3-like protein
    BRG1-associated factor 170
    SWI/SNF complex 170 kDa subunit
    chromatin remodeling complex BAF170 subunit
    mammalian chromatin remodeling complex BRG1-associated factor 170
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130420.1NP_001123892.1  SWI/SNF complex subunit SMARCC2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the middle coding region but lacks a segment in the 3' coding region as compared to variant 1. The reading frame is not affected, and isoform c contains an additional small segment in the middle region and lacks a bigger segment in the C-terminal region compared to isoform a.
      Source sequence(s)
      AB209006, BQ272432, BX476347, CX165574
      Consensus CDS
      CCDS55835.1
      UniProtKB/TrEMBL
      F8VTJ5
      UniProtKB/TrEMBL
      Q59GV3
      Related
      ENSP00000377591, OTTHUMP00000243474, ENST00000394023, OTTHUMT00000408459
      Conserved Domains (4) summary
      COG5259
      Location:379759
      Blast Score: 649
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      COG5271
      Location:244416
      Blast Score: 91
      MDN1; AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]
      pfam04433
      Location:428512
      Blast Score: 351
      SWIRM; SWIRM domain
      cl15261
      Location:187222
      Blast Score: 98
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    2. NM_003075.3NP_003066.2  SWI/SNF complex subunit SMARCC2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB209006, AK315153, BC009067, BQ272432, BX476347, CX165574
      Consensus CDS
      CCDS8907.1
      UniProtKB/TrEMBL
      Q59GV3
      UniProtKB/Swiss-Prot
      Q8TAQ2
      Related
      ENSP00000267064, OTTHUMP00000243441, ENST00000267064, OTTHUMT00000408370
      Conserved Domains (4) summary
      COG5259
      Location:379571
      Blast Score: 494
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      COG5271
      Location:244416
      Blast Score: 91
      MDN1; AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]
      pfam04433
      Location:428512
      Blast Score: 351
      SWIRM; SWIRM domain
      cl15261
      Location:187222
      Blast Score: 100
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    3. NM_139067.2NP_620706.1  SWI/SNF complex subunit SMARCC2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the middle coding region but lacks a segment in the 3' coding region as compared to variant 1. The reading frame is not affected, and isoform b contains an additional small segment in the middle region and lacks a big segment in the C-terminal region compared to isoform a.
      Source sequence(s)
      AB209006, BQ272432, BX476347, CX165574
      Consensus CDS
      CCDS8908.1
      UniProtKB/TrEMBL
      Q59GV3
      Related
      ENSP00000302919, OTTHUMP00000243447, ENST00000347471, OTTHUMT00000408379
      Conserved Domains (4) summary
      COG5259
      Location:379759
      Blast Score: 646
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      COG5271
      Location:244416
      Blast Score: 90
      MDN1; AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]
      pfam04433
      Location:428512
      Blast Score: 350
      SWIRM; SWIRM domain
      cl15261
      Location:187222
      Blast Score: 98
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      56555636..56583351, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      53594695..53620204, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073896.41 (144289..170454) None
    genomic CH471054.1 EAW96906.1
      EAW96907.1
      EAW96908.1
    mRNA AB209006.1 BAD92243.1
    mRNA AB209293.1 BAD92530.1
    mRNA AK025128.1 None
    mRNA AK293896.1 BAG57283.1
    mRNA AK315153.1 None
    mRNA BC009067.1 AAH09067.1
    mRNA BC013045.1 AAH13045.1
    mRNA BC026222.2 AAH26222.1
    mRNA BC040645.2 None
    mRNA BE326466.1 None
    mRNA BQ272432.1 None
    mRNA BT009924.1 AAP88926.1
    mRNA BX476347.1 None
    mRNA CB850719.1 None
    mRNA CX165574.1 None
    mRNA U66616.1 AAC50694.1
    mRNA AL833124.1 CAH56218.1
    other-genetic EU176256.1 ABW03707.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59G16 GenPept UniProtKB/TrEMBL:Q59G16
    Q59GV3 GenPept UniProtKB/TrEMBL:Q59GV3
    Q658P9 GenPept UniProtKB/TrEMBL:Q658P9
    Q8TAQ2.1 GenPept UniProtKB/Swiss-Prot:Q8TAQ2

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