RASL11B RAS-like, family 11, member B [Homo sapiens] - Gene

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Summary

Official Symbol: RASL11Bprovided by HGNC
Official Full Name: RAS-like, family 11, member Bprovided by HGNC
Primary source: HGNC:23804
See related: Ensembl:ENSG00000128045; HPRD:15216; MIM:612404; Vega:OTTHUMG00000102097
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGC2827; MGC4499
Summary: RASL11B is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

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Genomic context

Location :: 4q12

Sequence :: Chromosome: 4; NC_000004.11 (53728495..53733002)

See RASL11B in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RASL11B gene is expressed in all tissues investigated, with highest levels in placenta & primary macrophages. RASL11B may play a role in TGF-beta1-mediated developmental processes & in pathophysiologies such as inflammation, cancer, and arteriosclerosis.
Title: Cloning, genomic organization, and tissue-specific expression of the RASL11B gene.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
RAS like family 11, member B	Q01844	EWSR1	HPRD	PubMed
BioGRID:122444	BioGRID:108431	EWSR1	BioGRID	PubMed	Two-hybrid
BioGRID:122444	BioGRID:110811	NEDD4	BioGRID	PubMed	Reconstituted Complex
BioGRID:122444	BioGRID:116915	NEDD4L	BioGRID	PubMed	Reconstituted Complex
BioGRID:122444	BioGRID:247522	Nedd4	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: ras-like protein family member 11B

Names: ras-like protein family member 11B

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023940.2 → NP_076429.1 ras-like protein family member 11B

Status: PROVISIONAL

Source sequence(s)

BC001087

Consensus CDS

CCDS3490.1

UniProtKB/Swiss-Prot

Q9BPW5

Related

ENSP00000248706, OTTHUMP00000128290, ENST00000248706, OTTHUMT00000219931

Conserved Domains (1) summary

cd04146
Location:35 – 203
Blast Score: 652

RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

53728495..53733002

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

49672576..49677083

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC023154.5 (71508..76015)	None
genomic	CH471057.1	EAX05441.1
mRNA	AK027267.1	BAB55008.1
mRNA	AK314942.1	BAG37448.1
mRNA	AY839725.1	AAX46798.1
mRNA	AY839726.1	AAX46799.1
mRNA	BC001087.2	AAH01087.1
mRNA	BC001846.2	AAH01846.1
mRNA	BC025694.1	AAH25694.1
mRNA	BK001672.1	DAA02135.1