My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    DDRGK1 DDRGK domain containing 1 [ Homo sapiens ]

    Gene ID: 65992, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    DDRGK1provided by HGNC
    Official Full Name
    DDRGK domain containing 1provided by HGNC
    Primary source
    HGNC:16110
    See related
    Ensembl:ENSG00000198171; HPRD:12741; Vega:OTTHUMG00000031732
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UFBP1; C20orf116; dJ1187M17.3; MGC2592
    Help top of page

    Genomic context

    Location :
    20p13
    Sequence :
    Chromosome: 20; NC_000020.10 (3171012..3185295, complement)
    See DDRGK1 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134015 Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene ProSAPiP1 protein Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Neighboring gene solute carrier family 4, sodium borate transporter, member 11

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C. Tanaka Y, et al. Hum Mol Genet, 2011 Sep 1. PMID 21659334.
    2. Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. Lemaire K, et al. PLoS One, 2011 Apr 6. PMID 21494687.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients. Ochi H, et al. Gastroenterology, 2010 Oct. PMID 20637204.
    5. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. Wu J, et al. J Biol Chem, 2010 May 14. PMID 20228063.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. found that C53/LZAP and DDRGK1 became more susceptible to the proteasome-mediated degradation in RCAD knockdown cells, whereas their ubiquitination was significantly attenuated by RCAD overexpression
      Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C.

    ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:122441 BioGRID:123213 CDK5RAP3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:122441 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    DDRGK domain-containing protein 1
    Names
    DDRGK domain-containing protein 1
    Dashurin
    UFM1-binding protein 1 containing a PCI domain
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023935.1 → NP_076424.1  DDRGK domain-containing protein 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC000643
      Consensus CDS
      CCDS13050.1
      UniProtKB/Swiss-Prot
      Q96HY6
      Related
      ENSP00000346483, OTTHUMP00000030087, ENST00000354488, OTTHUMT00000077709
      Conserved Domains (1) summary
      pfam09756
      Location:189 – 303
      Blast Score: 385
      DDRGK; DDRGK domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      3171012..3185295, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      3118864..3133155, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121891.22 CAD55939.1
      CAD55940.1
    genomic AL121891.22 CAD55939.1
      CAD55940.1
    genomic CH471133.3 EAX10543.1
      EAX10544.1
    mRNA AF086090.1 None
    mRNA AK310809.1 None
    mRNA BC000643.1 AAH00643.1
    mRNA BC007957.1 AAH07957.1
    mRNA BC011851.1 AAH11851.1
    other-genetic HQ448262.1 ADQ32742.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96HY6.2 GenPept UniProtKB/Swiss-Prot:Q96HY6
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...