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    SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 [ Homo sapiens ]

    Gene ID: 6599, updated on 11-May-2012
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    Summary

    Official Symbol
    SMARCC1provided by HGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1provided by HGNC
    Primary source
    HGNC:11104
    See related
    Ensembl:ENSG00000173473; HPRD:03435; MIM:601732; Vega:OTTHUMG00000133519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Rsc8; SRG3; SWI3; BAF155; CRACC1
    Summary
    The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3p21.31
    Sequence :
    Chromosome: 3; NC_000003.11 (47627378..47823405, complement)
    See SMARCC1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene chromosome 3 open reading frame 75 Neighboring gene chondroitin sulfate proteoglycan 5 (neuroglycan C) Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 30 Neighboring gene microRNA 1226 Neighboring gene microtubule-associated protein 4 Neighboring gene vacuolar protein sorting 26 homolog B (S. pombe) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene. DelBove J, et al. Epigenetics, 2011 Dec. PMID 22139574.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    5. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454.

    See all (97) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer.
      Title: Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.
    2. Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12.
      Title: Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
    5. patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate than patients with low levels
      Title: Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.
    6. An increased expression of SMARCC1 protein was found in prostate cancer positively correlated with tumour dedifferentiation, progression, metastasis and time to recurrence.
      Title: SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation.
    7. Constitutive expression of SRG3 inhibits positive selection processes in T-cell receptor transgenic mice.
      Title: Down-regulation of the SWI/SNF chromatin remodeling activity by TCR signaling is required for proper thymocyte maturation.
    8. protein levels of BAF155/170 dictate the maximum cellular amount of BAF57
      Title: Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.
    9. BAF155 and potentially INI1 are substrates for Akt phosphorylation
      Title: Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003065.2 NP_057864.1 tax    BIND  PubMed Tax interacts with BAF155. 
    Q92922 P24864 CCNE1    HPRD  PubMed  
    Q92922 P17676 CEBPB    HPRD  PubMed  
    Q92922 O15360 FANCA    HPRD  PubMed  
    Q92922 Q13351 KLF1    HPRD  PubMed  
    Q92922 P04150 NR3C1    HPRD  PubMed  
    Q92922 Q01201 RELB    HPRD  PubMed  
    Q92922 Q96ST3 SIN3A    HPRD  PubMed  
    Q92922 P51532 SMARCA4    HPRD  PubMed  
    Q92922 Q6STE5 SMARCD3    HPRD  PubMed  
    BioGRID:112483 BioGRID:106631 ADD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112483 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:112483 BioGRID:1147430 ALL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:113894 ARID1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:121559 ARID1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112483 BioGRID:128219 ARID2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:198179 Ar    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112483 BioGRID:114691 BCL7C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:107140 BRCA1    BioGRID  PubMed Co-purification 
    BioGRID:112483 BioGRID:118883 BRD7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:198328 Bcl7b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:112483 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:107458 CDK8    BioGRID  PubMed Co-fractionation 
    BioGRID:112483 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:107533 CHD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:120775 CHD7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:111909 DPF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:108893 GATA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112483 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:113036 HSP90B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112483 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:115904 KLF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112483 BioGRID:122776 MCPH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112483 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:112483 BioGRID:114973 NCOR1    BioGRID  PubMed Co-purification 
    BioGRID:112483 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:110904 NONO    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112483 BioGRID:114012 NR0B2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:120490 PBRM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:115688 PRMT5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112483 BioGRID:111903 RELB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112483 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112483 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112483 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:112483 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:112485 SMARCC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112483 BioGRID:112486 SMARCD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112483 BioGRID:112489 SMARCE1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112483 BioGRID:112540 SOX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112550 SP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112483 BioGRID:112592 SRC    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:112483 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112650 STAT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:112670 STK11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112744 TAF10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:112761 TAT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112483 BioGRID:113010 TP53    BioGRID  PubMed Co-fractionation 
    BioGRID:112483 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112483 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:120250 WHSC1L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:119707 WWOX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112483 BioGRID:116244 WWP2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription from RNA polymerase II promoter NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    WINAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    XY body IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    npBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    SWI/SNF complex subunit SMARCC1
    Names
    SWI/SNF complex subunit SMARCC1
    BRG1-associated factor 155
    SWI/SNF complex 155 kDa subunit
    chromatin remodeling complex BAF155 subunit
    mammalian chromatin remodeling complex BRG1-associated factor 155
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003074.3 → NP_003065.3  SWI/SNF complex subunit SMARCC1

      Status: VALIDATED

      Source sequence(s)
      BC012101, BC040242, BC050564
      Consensus CDS
      CCDS2758.1
      UniProtKB/TrEMBL
      Q58EY4
      UniProtKB/Swiss-Prot
      Q92922
      Related
      ENSP00000254480, OTTHUMP00000164798, ENST00000254480, OTTHUMT00000257491
      Conserved Domains (4) summary
      COG5259
      Location:637 – 710
      Blast Score: 212
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      COG5271
      Location:272 – 447
      Blast Score: 98
      MDN1; AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]
      pfam04433
      Location:453 – 537
      Blast Score: 322
      SWIRM; SWIRM domain
      cl15261
      Location:215 – 250
      Blast Score: 84
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      47627378..47823405, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      47673262..47870748, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC026318.23 (61673..81175) None
    genomic AC112512.6 (122093..176909) None
    genomic AC130472.2 (72460..194159) None
    genomic CH471055.1 EAW64831.1
      EAW64832.1
    mRNA AK302412.1 BAG63721.1
    mRNA AK302541.1 BAG63813.1
    mRNA BC012101.1 None
    mRNA BC021862.1 AAH21862.1
    mRNA BC032564.1 AAH32564.1
    mRNA BC039843.1 AAH39843.1
    mRNA BC040242.1 None
    mRNA BC050564.1 AAH50564.1
    mRNA BC065253.1 AAH65253.1
    mRNA BC113465.1 AAI13466.1
    mRNA BC117213.1 AAI17214.1
    mRNA BG474088.1 None
    mRNA BM971095.1 None
    mRNA U66615.1 AAC50693.1
    other-genetic EU832157.1 ACE87507.1
    other-genetic EU832251.1 ACE86821.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05BW5 GenPept UniProtKB/TrEMBL:Q05BW5
    Q05CR1 GenPept UniProtKB/TrEMBL:Q05CR1
    Q58EY4 GenPept UniProtKB/TrEMBL:Q58EY4
    Q92922.3 GenPept UniProtKB/Swiss-Prot:Q92922
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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