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    Aacs acetoacetyl-CoA synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65984, updated on 15-Feb-2013
    Official Symbol
    Aacsprovided by RGD
    Official Full Name
    acetoacetyl-CoA synthetaseprovided by RGD
    Primary source
    RGD:708522
    See related
    Ensembl:ENSRNOG00000000967
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    activates acetoacetate to its CoA ester [RGD, Feb 2006]
    Location :
    12q14
    Sequence :
    Chromosome: 12; NC_005111.3 (38381585..38425026, complement)
    See Aacs in MapViewer

    Chromosome 12 - NC_005111.3Genomic Context describing neighboring genes Neighboring gene zinc finger protein 664-like Neighboring gene transmembrane protein 132B Neighboring gene Bri3 binding protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 37

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Genetic obesity affects neural ketone body utilization in the rat brain. Narishima R, et al. Obesity (Silver Spring), 2009 Mar. PMID 19219059.
    2. Ketone body utilization is regulated by male-specific factors in rat subcutaneous adipocytes. Yamasaki M, et al. Exp Clin Endocrinol Diabetes, 2009 Apr. PMID 19085696.
    3. Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell. MacDonald MJ, et al. J Biol Chem, 2007 Oct 19. PMID 17724028.
    4. Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes. Yamasaki M, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16055091.
    5. Cerebral ketone body metabolism. Morris AA. J Inherit Metab Dis, 2005. PMID 15877199.

    See all (16) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. As acetoacetyl-CoA synthetase was expressed in neural-like cells, ketone bodies are assumed to be utilized for the synthesis of lipidic substances and to cause metabolic disorders in the nervous system of genetically obese rats.
      Title: Genetic obesity affects neural ketone body utilization in the rat brain.
    2. AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development
      Title: Acetoacetyl-CoA synthetase gene is abundant in rat adipose, and related with fatty acid synthesis in mature adipocytes.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acetoacetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acetoacetate-CoA ligase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    butyrate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    adipose tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cellular response to cholesterol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cellular response to testosterone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    liver development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to oleic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to organic nitrogen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to purine-containing compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    white fat cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Preferred Names
    acetoacetyl-CoA synthetase
    Names
    acetoacetyl-CoA synthetase
    AcAc-CoA ligase
    acetoacetyl-CoA ligase
    acetoacetate-CoA ligase
    NP_075592.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023104.1 → NP_075592.1  acetoacetyl-CoA synthetase

      Status: PROVISIONAL

      Source sequence(s)
      AB026291
      UniProtKB/Swiss-Prot
      Q9JMI1
      Related
      ENSRNOP00000001292, ENSRNOT00000001292
      Conserved Domains (3) summary
      TIGR01217
      Location:16 – 671
      Blast Score: 3052
      ac_ac_CoA_syn; acetoacetyl-CoA synthase
      pfam00501
      Location:130 – 569
      Blast Score: 477
      AMP-binding; AMP-binding enzyme
      pfam11930
      Location:47 – 117
      Blast Score: 114
      DUF3448; Domain of unknown function (DUF3448)

    RefSeqs of Annotated Genomes: Build 5.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_5.0 Primary Assembly

    Genomic

    1. NC_005111.3 Reference Rnor_5.0 Primary Assembly

      Range
      38381585..38425026, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      32807686..32851029, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AABR06071900.1 (17534..56408) None
    genomic AABR06071901.1 None
    genomic AAHX01072330.1 (7826..39660) None
    genomic AAHX01072331.1 None
    genomic AAHX01072332.1 None
    genomic CH473973.1 EDM13548.1
      EDM13549.1
      EDM13550.1
      EDM13551.1
    mRNA AB026291.1 BAA90828.1 Sprague-Dawley
    mRNA BC061803.1 AAH61803.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMI1.1 GenPept UniProtKB/Swiss-Prot:Q9JMI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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