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    STK33 serine/threonine kinase 33 [ Homo sapiens ]

    Gene ID: 65975, updated on 11-May-2012
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    Summary

    Official Symbol
    STK33provided by HGNC
    Official Full Name
    serine/threonine kinase 33provided by HGNC
    Primary source
    HGNC:14568
    See related
    Ensembl:ENSG00000130413; HPRD:09642; MIM:607670; Vega:OTTHUMG00000140275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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    Genomic context

    Location :
    11p15.3
    Sequence :
    Chromosome: 11; NC_000011.9 (8413418..8615503, complement)
    See STK33 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene tubby homolog (mouse) Neighboring gene resistance to inhibitors of cholinesterase 3 homolog (C. elegans) Neighboring gene LIM domain only 1 (rhombotin 1) Neighboring gene tripartite motif containing 66 Neighboring gene uncharacterized LOC100652906 Neighboring gene ribosomal protein L27a

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Babij C, et al. Cancer Res, 2011 Sep 1. PMID 21742770.
    2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Speliotes EK, et al. Nat Genet, 2010 Nov. PMID 20935630.
    3. Analyses of shared genetic factors between asthma and obesity in children. Melén E, et al. J Allergy Clin Immunol, 2010 Sep. PMID 20816195.
    4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Fontaine-Bisson B, et al. Diabetologia, 2010 Oct. PMID 20571754.
    5. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Willer CJ, et al. Nat Genet, 2009 Jan. PMID 19079261.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells.
      Title: STK33 kinase activity is nonessential in KRAS-dependent cancer cells.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Analyses of shared genetic factors between asthma and obesity in children.
    3. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
    4. STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group
      Title: Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase 33
    Names
    serine/threonine-protein kinase 33
    NP_112168.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030906.2 → NP_112168.1  serine/threonine-protein kinase 33

      Status: VALIDATED

      Source sequence(s)
      AJ303380, AK093251, BC031231, BG722074
      Consensus CDS
      CCDS7789.1
      UniProtKB/Swiss-Prot
      Q9BYT3
      Related
      ENSP00000320754, OTTHUMP00000178934, ENST00000315204, OTTHUMT00000276816
      Conserved Domains (3) summary
      pfam06317
      Location:435 – 498
      Blast Score: 92
      Arena_RNA_pol; Arenavirus RNA polymerase
      cd05123
      Location:122 – 374
      Blast Score: 568
      STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
      smart00220
      Location:116 – 381
      Blast Score: 761
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      8413418..8615503, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      8081182..8222805, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC104360.8 (153605..170210) None
    genomic AC105357.7 (6175..167771) None
    genomic AP006442.2 (98055..121937) None
    genomic CH471064.2 EAW68623.1
      EAW68624.1
      EAW68625.1
    mRNA AJ303380.2 CAC29064.1
    mRNA AK092720.1 BAG52601.1
    mRNA AK093251.1 BAC04109.1
    mRNA AK122808.1 None
    mRNA AK293193.1 BAG56733.1
    mRNA AK310754.1 None
    mRNA AL833011.1 CAH56302.1
    mRNA BC031231.1 AAH31231.1
    mRNA BG722074.1 None
    other-genetic DQ891517.2 ABM82443.1
    other-genetic EU176614.1 ABW03415.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BYT3.1 GenPept UniProtKB/Swiss-Prot:Q9BYT3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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