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    SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [ Homo sapiens ]

    Gene ID: 6595, updated on 22-May-2012

    Summary

    Official Symbol
    SMARCA2provided by HGNC
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by HGNC
    Primary source
    HGNC:11098
    See related
    Ensembl:ENSG00000080503; HPRD:02483; MIM:600014; Vega:OTTHUMG00000019445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRM; SNF2; SWI2; hBRM; NCBRS; Sth1p; BAF190; SNF2L2; SNF2LA; hSNF2a; FLJ36757; MGC74511
    Summary
    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    9p22.3
    Sequence :
    Chromosome: 9; NC_000009.11 (2015342..2193624)
    See SMARCA2 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor 2 Neighboring gene ribosomal protein S27a pseudogene 14 Neighboring gene uncharacterized LOC401491 Neighboring gene very low density lipoprotein receptor Neighboring gene potassium channel, subfamily V, member 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat interacts directly with BRM, a DNA-dependent ATPase subunit of the SWI/SNF chromatin-remodeling complex, to activate the HIV-1 LTR, and this interaction is regulated by Tat lysine 50 acetylation PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003061.2 NP_002625.1 PHB    BIND  PubMed Prohibitin interacts with Brm. 
    P51531 O96019 ACTL6A    HPRD  PubMed  
    P51531 O94805 ACTL6B    HPRD  PubMed  
    P51531 Q8NFD5 ARID1B    HPRD  PubMed  
    P51531 P38398 BRCA1    HPRD  PubMed  
    P51531 P03372 ESR1    HPRD  PubMed  
    P51531 Q07666 KHDRBS1    HPRD  PubMed  
    P51531 P51608 MECP2    HPRD  PubMed  
    P51531 P04150 NR3C1    HPRD  PubMed  
    P51531 P35232 PHB    HPRD  PubMed  
    P51531 Q15532 SS18    HPRD  PubMed  
    BioGRID:112479 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification 
    BioGRID:112479 BioGRID:119529 ACTL6B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:106631 ADD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:1147430 ALL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:112479 BioGRID:113894 ARID1A    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:112479 BioGRID:121559 ARID1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:207995 Actl6a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:219970 Actl6b    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:116347 BAZ1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:107077 BCL7A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:198328 Bcl7b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:117030 CBX5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:107458 CDK8    BioGRID  PubMed Co-fractionation 
    BioGRID:112479 BioGRID:107475 CDX2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:111909 DPF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:108403 ESR1    BioGRID  PubMed Two-hybrid 
    BioGRID:112479 BioGRID:119246 GMNN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:160074 H3F3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:112479 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:112479 BioGRID:109338 HIF1A    BioGRID  PubMed Co-localization 
    BioGRID:112479 BioGRID:113946 HIST1H3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:125956 JOSD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:115900 KHDRBS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:119788 MBD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:122776 MCPH1    BioGRID  PubMed Affinity Capture-Western 
    NP_004983.1 MECP2    BIND  PubMed MeCP2 interacts with Brm. 
    BioGRID:112479 BioGRID:110368 MECP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:110687 MYB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:110694 MYC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:114012 NR0B2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:110983 NR4A2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:111324 PITX1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:111426 POLR2A    BioGRID  PubMed Co-fractionation; Co-localization; Co-purification 
    BioGRID:112479 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:117298 PRPF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:112479 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:114166 RUVBL1    BioGRID  PubMed Co-fractionation 
    BioGRID:112479 BioGRID:114346 SAP30    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:112479 BioGRID:116901 SIN3B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:112479 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112479 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112479 BioGRID:112485 SMARCC2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:112479 BioGRID:112486 SMARCD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112479 BioGRID:112487 SMARCD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:112489 SMARCE1    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:112479 BioGRID:112638 SS18    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112479 BioGRID:112635 SSX2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112479 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:112743 TAF9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:112761 TAT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112479 BioGRID:112771 TBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112479 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:120250 WHSC1L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:122151 ZMAT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112479 BioGRID:115989 ZMYND11    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-dependent ATPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA polymerase II transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    WINAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    npBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    probable global transcription activator SNF2L2
    Names
    probable global transcription activator SNF2L2
    BAF190B
    SNF2-alpha
    protein brahma homolog
    SNF2/SWI2-like protein 2
    BRG1-associated factor 190B
    ATP-dependent helicase SMARCA2
    sucrose nonfermenting 2-like protein 2
    global transcription activator homologous sequence
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032162.1 RefSeqGene

      Range
      5001..183283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003070.3NP_003061.3  probable global transcription activator SNF2L2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK094076, AL558829, BC040029, BC066596, BC068252, X72889
      Consensus CDS
      CCDS34977.1
      UniProtKB/Swiss-Prot
      P51531
      UniProtKB/TrEMBL
      Q56A76
      UniProtKB/TrEMBL
      Q8N9Q1
      Related
      ENSP00000265773, ENST00000349721
      Conserved Domains (7) summary
      cd00046
      Location:744883
      Blast Score: 225
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10401172
      Blast Score: 244
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd05516
      Location:13821506
      Blast Score: 474
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      pfam00176
      Location:7271022
      Blast Score: 954
      SNF2_N; SNF2 family N-terminal domain
      cl02676
      Location:451508
      Blast Score: 181
      HSA; HSA
      cl02688
      Location:588632
      Blast Score: 173
      BRK; BRK domain
      cl07469
      Location:172208
      Blast Score: 149
      QLQ; QLQ
    2. NM_139045.2NP_620614.2  probable global transcription activator SNF2L2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AK094076, BC040029, BC066596, BC068252, X72889
      Consensus CDS
      CCDS34978.1
      UniProtKB/Swiss-Prot
      P51531
      UniProtKB/TrEMBL
      Q56A76
      UniProtKB/TrEMBL
      Q8N9Q1
      Related
      ENSP00000349788, ENST00000357248
      Conserved Domains (7) summary
      cd00046
      Location:744883
      Blast Score: 224
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:10401172
      Blast Score: 244
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd05516
      Location:13821488
      Blast Score: 502
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      pfam00176
      Location:7271022
      Blast Score: 954
      SNF2_N; SNF2 family N-terminal domain
      cl02676
      Location:451508
      Blast Score: 180
      HSA; HSA
      cl02688
      Location:588632
      Blast Score: 173
      BRK; BRK domain
      cl07469
      Location:172208
      Blast Score: 149
      QLQ; QLQ

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      2015342..2193624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      1969240..2147484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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