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SNAI2 snail family zinc finger 2 [ Homo sapiens (human) ]

Gene ID: 6591, updated on 19-Jul-2014
Official Symbol
SNAI2provided by HGNC
Official Full Name
snail family zinc finger 2provided by HGNC
Primary source
HGNC:11094
See related
Ensembl:ENSG00000019549; HPRD:03689; MIM:602150; Vega:OTTHUMG00000149912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLUG; WS2D; SLUGH1; SNAIL2
Summary
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
See SNAI2 in Epigenomics, MapViewer
Location:
8q11
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (48917677..48921440, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (49830236..49833999, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929268 Neighboring gene uncharacterized LOC101929217 Neighboring gene EF-hand calcium binding domain 1 Neighboring gene chromosome 8 open reading frame 22 Neighboring gene ret finger protein-like 4A pseudogene 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of snail homolog 2 (Drosophila) (SNAI2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu leads to the depression of both total and beta-catenin-associated E-cadherin levels through Vpu-induced upregulation of the transcriptional repressor Snail PubMed
vpu HIV-1 Vpu upregulates the expression of Snail in HeLa cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC10182

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
cartilage morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
desmosome disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of catenin import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell adhesion involved in substrate-bound cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion mediated by integrin IC
Inferred by Curator
more info
PubMed 
negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vitamin D biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vitamin D receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
 
palate development IEA
Inferred from Electronic Annotation
more info
 
pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
 
regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
zinc finger protein SNAI2
Names
zinc finger protein SNAI2
snail homolog 2
protein snail homolog 2
neural crest transcription factor SLUG
slug (chicken homolog), zinc finger protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012130.1 

    Range
    4990..8753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003068.4NP_003059.1  zinc finger protein SNAI2

    See proteins identical to NP_003059.1

    Status: REVIEWED

    Source sequence(s)
    AC013701, BC015895, DA522147
    Consensus CDS
    CCDS6146.1
    UniProtKB/Swiss-Prot
    O43623
    Related
    ENSP00000020945, ENST00000020945
    Conserved Domains (2) summary
    COG5048
    Location:182258
    Blast Score: 84
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:200223
    Blast Score: 87
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    48917677..48921440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    45294292..45298055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    49882550..49886313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)