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SLIT1 slit guidance ligand 1 [ Homo sapiens (human) ]

Gene ID: 6585, updated on 26-May-2016
Official Symbol
SLIT1provided by HGNC
Official Full Name
slit guidance ligand 1provided by HGNC
Primary source
HGNC:HGNC:11085
See related
Ensembl:ENSG00000187122 HPRD:04773; MIM:603742; Vega:OTTHUMG00000018843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEGF4; SLIL1; SLIT3; SLIT-1
Orthologs
Location:
10q23.3-q24
Exon count:
37
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (96998038..97185926, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (98757795..98945683, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ligand dependent nuclear receptor corepressor Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 35 Neighboring gene chromosome 10 open reading frame 12 Neighboring gene uncharacterized LOC105378444 Neighboring gene SLIT1 antisense RNA 1 Neighboring gene ARHGAP19-SLIT1 readthrough (NMD candidate) Neighboring gene uncharacterized LOC105378445 Neighboring gene uncharacterized LOC105378446

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
    Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough ARHGAP19-SLIT1

Readthrough gene: ARHGAP19-SLIT1, Included gene: ARHGAP19

Homology

Clone Names

  • MGC164811

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Roundabout binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
Roundabout signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
NOT chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
Inferred from Direct Assay
more info
PubMed 
dorsal/ventral axon guidance IEA
Inferred from Electronic Annotation
more info
 
establishment of nucleus localization IEA
Inferred from Electronic Annotation
more info
 
forebrain morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
proteinaceous extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
slit homolog 1 protein
Names
multiple EGF-like domains protein 4
multiple epidermal growth factor-like domains protein 4
slit homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003061.2NP_003052.2  slit homolog 1 protein precursor

    See identical proteins and their annotated locations for NP_003052.2

    Status: VALIDATED

    Source sequence(s)
    AL512424, BC028105, BC146761, CD671648
    Consensus CDS
    CCDS7453.1
    UniProtKB/Swiss-Prot
    O75093
    UniProtKB/TrEMBL
    A6H8V1
    Related
    ENSP00000266058, OTTHUMP00000020182, ENST00000266058, OTTHUMT00000049636
    Conserved Domains (8) summary
    smart00013
    Location:3364
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:866915
    LRRCT; Leucine rich repeat C-terminal domain
    cd00054
    Location:10851119
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:11671320
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00116
    Location:87220
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam12799
    Location:334373
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:590649
    LRR_8; Leucine rich repeat
    sd00033
    Location:4362
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    96998038..97185926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    99040092..99227937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)