Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 [ Homo sapiens (human) ]

Gene ID: 6566, updated on 19-Jul-2014
Official Symbol
SLC16A1provided by HGNC
Official Full Name
solute carrier family 16 (monocarboxylate transporter), member 1provided by HGNC
Primary source
HGNC:10922
Locus tag
RP4-580L15.1
See related
Ensembl:ENSG00000155380; HPRD:02816; MIM:600682; Vega:OTTHUMG00000012129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT; HHF7; MCT1
Summary
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
See SLC16A1 in Epigenomics, MapViewer
Location:
1p12
Exon count :
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (112911847..112956353, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113454469..113498975, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1356 Neighboring gene ribosomal protein L39 pseudogene 8 Neighboring gene aldo-keto reductase family 7, member A2 pseudogene 1 Neighboring gene SLC16A1 antisense RNA 1 Neighboring gene uncharacterized LOC101930375

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Basigin interactions, organism-specific biosystem (from REACTOME)
    Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Proton-coupled monocarboxylate transport, organism-specific biosystem (from REACTOME)
    Proton-coupled monocarboxylate transport, organism-specific biosystemThe SLC16A gene family encode proton-linked monocarboxylate transporters (MCT) which mediate the transport of monocarboxylates such as lactate and pyruvate. Monocarboxylates are a major energy source...
  • Pyruvate metabolism, organism-specific biosystem (from REACTOME)
    Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
  • Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
    Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemPyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the r...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
    The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem (from REACTOME)
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystemHexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse acro...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mevalonate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
organic cyclic compound binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
secondary active monocarboxylate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
cellular metabolic process TAS
Traceable Author Statement
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
centrosome organization IMP
Inferred from Mutant Phenotype
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
mevalonate transport TAS
Traceable Author Statement
more info
PubMed 
monocarboxylic acid transport TAS
Traceable Author Statement
more info
PubMed 
plasma membrane lactate transport ISS
Inferred from Sequence or Structural Similarity
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
monocarboxylate transporter 1
Names
monocarboxylate transporter 1
MCT 1
solute carrier family 16 member 1
solute carrier family 16 (monocarboxylic acid transporters), member 1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015880.1 

    Range
    5001..49507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166496.1NP_001159968.1  monocarboxylate transporter 1

    See proteins identical to NP_001159968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI656300, AK094064, AK296688, AL162079, BC026317, BP294493
    Consensus CDS
    CCDS858.1
    UniProtKB/TrEMBL
    B4DKS0
    UniProtKB/Swiss-Prot
    P53985
    Related
    ENSP00000441065, ENST00000538576
    Conserved Domains (2) summary
    cd06174
    Location:20439
    Blast Score: 248
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    Blast Score: 1754
    2A0113; monocarboxylate transporter 1
  2. NM_003051.3NP_003042.3  monocarboxylate transporter 1

    See proteins identical to NP_003042.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ438943, AL162079, BC026317, BM712667, DB443025
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985
    Related
    ENSP00000358640, OTTHUMP00000013960, ENST00000369626, OTTHUMT00000033539
    Conserved Domains (2) summary
    cd06174
    Location:20439
    Blast Score: 248
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:1455
    Blast Score: 1754
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    112911847..112956353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    111313328..111357846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    113569526..113614046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...