My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) [ Homo sapiens ]

    Gene ID: 6566, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    SLC16A1provided by HGNC
    Official Full Name
    solute carrier family 16, member 1 (monocarboxylic acid transporter 1)provided by HGNC
    Primary source
    HGNC:10922
    Locus tag
    RP4-580L15.1
    See related
    Ensembl:ENSG00000155380; HPRD:02816; MIM:600682; Vega:OTTHUMG00000012129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT; HHF7; MCT1; FLJ36745; MGC44475
    Summary
    The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
    Help top of page

    Genomic context

    Location :
    1p12
    Sequence :
    Chromosome: 1; NC_000001.10 (113454469..113498975, complement)
    See SLC16A1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2-like Neighboring gene ribosomal protein L39 pseudogene 8 Neighboring gene aldo-keto reductase family 7, member A2 pseudogene 1 Neighboring gene uncharacterized LOC100506392 Neighboring gene leucine-rich repeats and immunoglobulin-like domains 2

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Boidot R, et al. Cancer Res, 2012 Feb 15. PMID 22184616.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Le Floch R, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21930917.
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. our findings identify MCT1 as a target for p53 repression and they suggest that MCT1 elevation in p53-deficient tumors allows them to adapt to metabolic needs by facilitating lactate export or import depending on the glucose availability.
      Title: Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.
    2. MCT1 gene plays an important role in pHi regulation, lactate transport and cell growth in tumor cells.
      Title: [The effect of monocarboxylate transporter gene on the regulation of pHi and growth character in cancer cells].
    3. Data show that a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue.
      Title: Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.
    4. both MCT1 and CD147, but not MCT4, were associated with GLUT1 and CAIX expression in a large series of invasive breast carcinoma samples
      Title: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression.
    5. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
      Title: CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
    6. Loss of MCT1 on brain microvessels is mechanistically involved in the pathophysiology of drug-resistant temporal lobe epilepsy; re-expression of MCT1 may represent a novel therapeutic approach for this disease.
      Title: Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus.
    7. miR-29a, miR-29b selectively target MCT1 3'UTR ; the miR-29 isoforms are highly expressed in islets and contribute to silencing Mct1 in beta cells; miR-29 isoforms contribute to beta-cell-specific silencing of the MCT1 transporter and may affect insuli...
      Title: miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1).
    8. We found that the expression of the monocarboxylate transporters MCT1 and MCT4, but not MCT5, in human lung cancer cell lines was significantly correlated with invasiveness
      Title: Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells.
    9. carriers of the A1470T polymorphism in the MTC1 (monocarboxylate transporter 1) gene exhibit a worse lactate transport capability
      Title: MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study.
    10. results provide evidence for a prognostic value of MCT1 in breast carcinoma
      Title: Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma.
    Submit: New GeneRIF Correction See all (46)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Erythrocyte lactate transporter defect

    Hyperinsulinemic hypoglycemia, familial, 7

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P53985 P35613 BSG    HPRD  PubMed  
    BioGRID:112454 BioGRID:107588 AP1S1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112454 BioGRID:107147 BSG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112454 BioGRID:114130 DEGS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112454 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112454 BioGRID:116155 SERINC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112454 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Basigin interactions, organism-specific biosystem (from REACTOME)
      Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Proton-coupled monocarboxylate transport, organism-specific biosystem (from REACTOME)
      Proton-coupled monocarboxylate transport, organism-specific biosystemThe SLC16A gene family encode proton-linked monocarboxylate transporters (MCT) which mediate the transport of monocarboxylates such as lactate and pyruvate. Monocarboxylates are a major energy source...
    • Pyruvate metabolism, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
    • Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemPyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the r...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
      The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem (from REACTOME)
      Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystemHexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse acro...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mevalonate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    monocarboxylic acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    secondary active monocarboxylate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    mevalonate transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    monocarboxylic acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    organic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    pyruvate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    monocarboxylate transporter 1
    Names
    monocarboxylate transporter 1
    MCT 1
    solute carrier family 16 member 1
    solute carrier family 16 (monocarboxylic acid transporters), member 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015880.1 RefSeqGene

      Range
      5001..49507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001166496.1 → NP_001159968.1  monocarboxylate transporter 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI656300, AK094064, AK296688, AL162079, BC026317, BP294493
      Consensus CDS
      CCDS858.1
      UniProtKB/TrEMBL
      B4DKS0
      UniProtKB/Swiss-Prot
      P53985
      Related
      ENSP00000441065, ENST00000538576
      Conserved Domains (2) summary
      cd06174
      Location:20 – 198
      Blast Score: 187
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:1 – 448
      Blast Score: 1707
      2A0113; monocarboxylate transporter 1

    2. NM_003051.3 → NP_003042.3  monocarboxylate transporter 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ438943, AL162079, BC026317, BM712667, DB443025
      Consensus CDS
      CCDS858.1
      UniProtKB/Swiss-Prot
      P53985
      Related
      ENSP00000358640, OTTHUMP00000013960, ENST00000369626, OTTHUMT00000033539
      Conserved Domains (2) summary
      cd06174
      Location:20 – 198
      Blast Score: 187
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:1 – 448
      Blast Score: 1707
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      113454469..113498975, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      111313328..111357846, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AJ438945.1 CAD27707.1
    genomic AL158844.14 CAI21872.1
      CAI21873.1
      CAI21874.1
      CAI21875.1
    genomic CH471122.1 EAW56551.1
      EAW56552.1
      EAW56553.1
    mRNA AF239919.1 None
    mRNA AI656300.1 None
    mRNA AJ438942.2 None
    mRNA AJ438943.2 None
    mRNA AK000641.1 None
    mRNA AK094064.1 None
    mRNA AK296688.1 BAG59282.1
    mRNA AK303603.1 BAG64618.1
    mRNA AK312500.1 BAG35402.1
    mRNA AL162079.1 CAB82412.1
    mRNA BC026317.1 AAH26317.1
    mRNA BC045664.1 AAH45664.1
    mRNA BM712667.1 None
    mRNA BP294493.1 None
    mRNA DB443025.1 None
    mRNA L31801.1 AAC41707.1
    other-genetic DQ895286.2 ABM86212.1
    other-genetic EU176206.1 ABW03657.1
    other-genetic EU831949.1 ACE87390.1
    other-genetic EU832043.1 ACE86705.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53985.3 GenPept UniProtKB/Swiss-Prot:P53985
    Q49A45 GenPept UniProtKB/TrEMBL:Q49A45
    Q5T8R3 GenPept UniProtKB/TrEMBL:Q5T8R3
    Q5T8R4 GenPept UniProtKB/TrEMBL:Q5T8R4
    Q5T8R5 GenPept UniProtKB/TrEMBL:Q5T8R5
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...