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BMP8B bone morphogenetic protein 8b [ Homo sapiens (human) ]

Gene ID: 656, updated on 8-May-2016
Official Symbol
BMP8Bprovided by HGNC
Official Full Name
bone morphogenetic protein 8bprovided by HGNC
Primary source
HGNC:HGNC:1075
See related
Ensembl:ENSG00000116985 HPRD:03792; MIM:602284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OP2; BMP8
Summary
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p35-p32
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (39757182..39788861, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40223903..40254533, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hippocalcin like 4 Neighboring gene coiled-coil domain containing 25 pseudogene Neighboring gene peptidylprolyl isomerase E Neighboring gene uncharacterized LOC105378666 Neighboring gene 3-oxoacid CoA-transferase 2 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene uncharacterized LOC101929536 Neighboring gene uncharacterized LOC105378665

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • BMP signaling, organism-specific biosystem (from KEGG)
    BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • BMP signaling, conserved biosystem (from KEGG)
    BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC131757

Gene Ontology Provided by GOA

Function Evidence Code Pubs
BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
growth IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
bone morphogenetic protein 8B
Names
BMP-8
BMP-8B
bone morphogenetic protein 8 (osteogenic protein 2)
dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2))
osteogenic protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001720.3NP_001711.2  bone morphogenetic protein 8B preproprotein

    See identical proteins and their annotated locations for NP_001711.2

    Status: REVIEWED

    Source sequence(s)
    AY303955, BC023526, BQ888513
    Consensus CDS
    CCDS444.1
    UniProtKB/Swiss-Prot
    P34820
    Related
    ENSP00000361915, OTTHUMP00000010836, ENST00000372827, OTTHUMT00000025641
    Conserved Domains (2) summary
    smart00204
    Location:301402
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:33251
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    39757182..39788861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542023.1XP_011540325.1  

    Conserved Domains (2) summary
    smart00204
    Location:206307
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:15156
    TGFb_propeptide; TGF-beta propeptide
  2. XM_011542022.1XP_011540324.1  

    Conserved Domains (2) summary
    smart00204
    Location:301353
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:33251
    TGFb_propeptide; TGF-beta propeptide
  3. XM_011542024.1XP_011540326.1  

    Conserved Domains (1) summary
    pfam00688
    Location:33229
    TGFb_propeptide; TGF-beta propeptide
  4. XM_011542025.1XP_011540327.1  

    Conserved Domains (1) summary
    pfam00688
    Location:33224
    TGFb_propeptide; TGF-beta propeptide
  5. XM_005271149.3XP_005271206.1  

    Conserved Domains (1) summary
    pfam00688
    Location:33225
    TGFb_propeptide; TGF-beta propeptide

RNA

  1. XR_946748.1 RNA Sequence

  2. XR_946749.1 RNA Sequence

  3. XR_946750.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    40339343..40370012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)