BMP7 bone morphogenetic protein 7 [Homo sapiens] - Gene

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Summary

Official Symbol: BMP7provided by HGNC
Official Full Name: bone morphogenetic protein 7provided by HGNC
Primary source: HGNC:1074
See related: Ensembl:ENSG00000101144; HPRD:00212; MIM:112267; Vega:OTTHUMG00000032812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OP-1
Summary: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q13

Sequence :: Chromosome: 20; NC_000020.10 (55743809..55841707, complement)

See BMP7 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

components of the common cellular transcriptional response to BMP4 and BMP7
Title: Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes.
These findings indicate that F-spondin regulates the differentiation of human cementoblast-like cells via BMP7 expression.
Title: F-spondin regulates the differentiation of human cementoblast-like (HCEM) cells via BMP7 expression.
Single-nucleotide polymorphisms in the KITLG gene showed significant associations with testicular cancer
Title: A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation.
these data show that BMP-4 and BMP-7 are associated with granulosa cell survival via several non-Smad specific pathways: BMP-4 via the PI3K/PDK-1/PKC and BMP-7 via the PI3K/PDK-1/Akt.
Title: Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC.
the involvement of BMP7 in several pathological conditions, such as incomplete fracture healing, osteoarthritis, the development of bone metastases, renal fibrosis and obesity.
Title: Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency.
Gene array data strongly suggest a critical role of OP-1 in human cartilage homeostasis
Title: Regulation of chondrocyte gene expression by osteogenic protein-1.
the BMP7-BMPR2-p38-NDRG1 axis plays a critical role in dormancy and recurrence of prostate CSCs in bone
Title: Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone.
Findings suggested that BMP7 may stimulate insulin secretion and improve islet cell function in humans.
Title: Serum bone morphogenetic protein 7, insulin resistance, and insulin secretion in non-diabetic individuals.
Mechanical loading upregulates BMP7, likely via the VDR, but not BMP2, gene and protein expression in osteocytes in vitro.
Title: Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes.
The rs6025422 polymorphism in the BMP7 gene is linked with hypertriglyceridemia phenotype in Uygur Chinese population.
Title: [Genetic variations of bone morphogenetic protein 7 gene are associated with hypertriglyceridemia of Uygur Chinese in Xinjiang].

Submit: New GeneRIF Correction See all (111)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genomewide association study of citalopram response in major depressive disorder.

Identification of nine novel Loci associated with white blood cell subtypes in a Japanese population.

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Products	Interactant	Other Gene	Source	Pubs	Description
P18075	Q04771	ACVR1	HPRD	PubMed
P18075	P27037	ACVR2A	HPRD	PubMed
P18075	Q13705	ACVR2B	HPRD	PubMed
P18075	P36894	BMPR1A	HPRD	PubMed
P18075	O00238	BMPR1B	HPRD	PubMed
P18075	Q13873	BMPR2	HPRD	PubMed
P18075	Q6WN34	CHRDL2	HPRD	PubMed
P18075	P17813	ENG	HPRD	PubMed
P18075	Q7Z4P5	GDF7	HPRD	PubMed
P18075	Q9Y6Q9	NCOA3	HPRD	PubMed
P18075	Q13253	NOG	HPRD	PubMed
P18075	Q6X4U4	SOSTDC1	HPRD	PubMed
BioGRID:107123	BioGRID:106605	ACVR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107123	BioGRID:106607	ACVR2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107123	BioGRID:106608	ACVR2B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107123	BioGRID:107123	BMP7	BioGRID	PubMed	Co-purification
BioGRID:107123	BioGRID:107125	BMPR1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:107123	BioGRID:107126	BMPR1B	BioGRID	PubMed	Reconstituted Complex
BioGRID:107123	BioGRID:107127	BMPR2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107123	BioGRID:108337	ENG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107123	BioGRID:114668	NOG	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:107123	BioGRID:110261	SMAD1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:107123	BioGRID:110263	SMAD3	BioGRID	PubMed	Co-localization
BioGRID:107123	BioGRID:117428	SOSTDC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107123	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
anatomical structure formation involved in morphogenesis	IEA Inferred from Electronic Annotation more info
axon guidance	IEA Inferred from Electronic Annotation more info
branching involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
branching morphogenesis of a tube	IEA Inferred from Electronic Annotation more info
cartilage development	IEA Inferred from Electronic Annotation more info
cell development	IEA Inferred from Electronic Annotation more info
cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
embryonic camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
embryonic limb morphogenesis	IEA Inferred from Electronic Annotation more info
embryonic pattern specification	IEA Inferred from Electronic Annotation more info
embryonic skeletal joint morphogenesis	IEA Inferred from Electronic Annotation more info
epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
epithelial to mesenchymal transition	TAS Traceable Author Statement more info	PubMed
eye development	IEA Inferred from Electronic Annotation more info
growth	IEA Inferred from Electronic Annotation more info
mesenchymal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
mesenchyme development	ISS Inferred from Sequence or Structural Similarity more info
mesoderm formation	IEA Inferred from Electronic Annotation more info
mesonephros development	IEP Inferred from Expression Pattern more info	PubMed
metanephric mesenchymal cell proliferation involved in metanephros development	IEA Inferred from Electronic Annotation more info
metanephric mesenchyme morphogenesis	IEA Inferred from Electronic Annotation more info
metanephros development	IEP Inferred from Expression Pattern more info	PubMed
monocyte aggregation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of NF-kappaB import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell death	IDA Inferred from Direct Assay more info	PubMed
negative regulation of glomerular mesangial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis	IEA Inferred from Electronic Annotation more info
negative regulation of mitosis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of prostatic bud formation	IEA Inferred from Electronic Annotation more info
negative regulation of striated muscle cell apoptosis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
nephrogenic mesenchyme morphogenesis	IEA Inferred from Electronic Annotation more info
neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
organ morphogenesis	IEA Inferred from Electronic Annotation more info
ossification	IEA Inferred from Electronic Annotation more info
pathway-restricted SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell death	IEA Inferred from Electronic Annotation more info
positive regulation of heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of pathway-restricted SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
regulation of branching involved in prostate gland morphogenesis	IEA Inferred from Electronic Annotation more info
regulation of removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
skeletal system development	TAS Traceable Author Statement more info	PubMed
steroid hormone mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: bone morphogenetic protein 7

Names: bone morphogenetic protein 7; BMP-7; osteogenic protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001719.2 → NP_001710.1 bone morphogenetic protein 7 precursor

Status: REVIEWED

Source sequence(s)

AK291186, AL157414, BM683430, DA740733

Consensus CDS

CCDS13455.1

UniProtKB/TrEMBL

A8K571

UniProtKB/Swiss-Prot

P18075

Related

ENSP00000379204, OTTHUMP00000031357, ENST00000395863, OTTHUMT00000079831

Conserved Domains (2) summary

pfam00688
Location:34 – 280
Blast Score: 568

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:330 – 431
Blast Score: 507

TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

55743809..55841707, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

52525580..52623004, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF210054.1	AAG43508.1
genomic	AF289090.1	AAF97256.1
genomic	AL122058.19	CAB90273.2
genomic	AL157414.19	CAC08434.2
genomic	CH471077.2	EAW75529.1
		EAW75530.1
		EAW75531.1
genomic	CQ786476.1	CAG17752.1
genomic	CS150682.1	CAJ29673.1
genomic	CS237122.1	CAJ47525.1
genomic	CS279049.1	CAJ86525.1
genomic	CS284582.1	CAJ98562.1
genomic	CS410513.1	CAL47728.1
genomic	CS455741.1	CAL85403.1
genomic	CS670983.1	CAP07469.1
genomic	GM868923.1	CAV07685.1
genomic	HC190935.1	CBI69260.1
mRNA	AK094784.1	None
mRNA	AK291186.1	BAF83875.1
mRNA	AK312419.1	BAG35329.1
mRNA	BC004248.1	None
mRNA	BC008584.1	AAH08584.1
mRNA	BM683430.1	None
mRNA	DA740733.1	None
mRNA	EU679366.1	ACD50899.1
mRNA	M60316.1	AAA36738.1
mRNA	X51801.1	CAA36100.1
other-genetic	DQ891494.2	ABM82420.1
other-genetic	DQ894685.2	ABM85611.1
other-genetic	EU176612.1	ABW03413.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P18075.1	GenPept	UniProtKB/Swiss-Prot:P18075
Q9H2W7	GenPept	UniProtKB/TrEMBL:Q9H2W7
Q9NQQ8	GenPept	UniProtKB/TrEMBL:Q9NQQ8